DOI: 10.1126/science.6287572. Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

10.1126/science.6287572

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Harvey murine sarcoma virus is a retrovirus which transforms cells by means of a single virally encoded protein called p21 has. We have determined the nucleotide sequence of 1.0 kilobase in the 5′ half of the viral genome which encompasses the has coding sequences and its associated regulatory signals. The nucleotide sequence has identified the amino acid sequence of two additional overlapping polypeptides which share their reading frames and the carboxyl termini with p21 but which contain additional NH 2 -terminal amino acids.

Bibliography

Dhar, R., Ellis, R. W., Shih, T. Y., Oroszlan, S., Shapiro, B., Maizel, J., Lowy, D., & Scolnick, E. (1982). Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus. Science, 217(4563), 934â936.

Authors 8

Ravi Dhar (first)
Ronald W. Ellis (additional)
Thomas Y. Shih (additional)
Stephen Oroszlan (additional)
Bruce Shapiro (additional)
Jacob Maizel (additional)
Douglas Lowy (additional)
Edward Scolnick (additional)

References 26 Referenced 195

BARBACID M COMMUNICATION.
10.1016/0092-8674(80)90385-2
Chang, E. H., Proceedings of the National Academy of Sciences of the United States of America 79: 4848 (1982). / Proceedings of the National Academy of Sciences of the United States of America (1982)
DeFeo, D., Proceedings of the National Academy of Sciences of the United States of America 78: 3328 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
DHAR R unpublished data.
ELLIS R.W. ADVANCES IN VIRAL ONCOLOGY 1 (1982). (10.1097/00012272-198207000-00002)
ELLIS, R.W., DUAL EVOLUTIONARY ORIGIN FOR THE RAT GENETIC SEQUENCES OF HARVEY MURINE SARCOMA-VIRUS, JOURNAL OF VIROLOGY 36: 408 (1980). (10.1128/jvi.36.2.408-420.1980) / JOURNAL OF VIROLOGY (1980)
ELLIS, R.W., THE P21 SRC GENES OF HARVEY AND KIRSTEN SARCOMA-VIRUSES ORIGINATE FROM DIVERGENT MEMBERS OF A FAMILY OF NORMAL VERTEBRATE GENES, NATURE 292: 506 (1981). (10.1038/292506a0) / NATURE (1981)
FOWLKES, D.M., TRANSCRIPTIONAL CONTROL REGIONS OF THE ADENOVIRUS VAI RNA GENE, CELL 22: 405 (1980). (10.1016/0092-8674(80)90351-7) / CELL (1980)
GOLDBERG P THESIS STANFORD U (1979).
GRUSS, P, SV40 RECOMBINANT MOLECULES EXPRESS THE GENE ENCODING P21 TRANSFORMING PROTEIN OF HARVEY MURINE SARCOMA-VIRUS, NATURE 293: 486 (1981). (10.1038/293486a0) / NATURE (1981)
KOZAK, M, Mechanism of mRNA Recognition by Eukaryotic Ribosomes During Initiation of Protein Synthesis, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 93: 81 (1981). / CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY / Mechanism of mRNA Recognition by Eukaryotic Ribosomes During Initiation of Protein Synthesis (1981)
Kozak, M., Journal of Virology 42: 467 (1982). (10.1128/jvi.42.2.467-473.1982) / Journal of Virology (1982)
LANGBEHEIM, H, IDENTIFICATION OF A NORMAL VERTEBRATE CELL PROTEIN RELATED TO THE P21 SRC OF HARVEY MURINE SARCOMA-VIRUS, VIROLOGY 106: 292 (1980). (10.1016/0042-6822(80)90252-4) / VIROLOGY (1980)
10.1073/pnas.74.2.560
OROSZLAN T.A. unpublished data.
OSTROWSKI, M.C., SPECIFIC TRANSCRIPTIONAL INITIATION INVITRO ON MURINE TYPE-C RETROVIRUS PROMOTERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 4485 (1981). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1981)
SEIF, I, A RAPID ENZYMATIC DNA SEQUENCING TECHNIQUE - DETERMINATION OF SEQUENCE ALTERATIONS IN EARLY SIMIAN VIRUS-40 TEMPERATURE SENSITIVE AND DELETION MUTANTS, NUCLEIC ACIDS RESEARCH 8: 2225 (1980). (10.1093/nar/8.10.2225) / NUCLEIC ACIDS RESEARCH (1980)
Shapiro, B., Proceedings of the 4th Annual WAMI Meeting: 93 (1981). / Proceedings of the 4th Annual WAMI Meeting (1981)
Shih, T. Y., Journal of Biological Chemistry 257: 11767 (1982). (10.1016/S0021-9258(18)33830-4) / Journal of Biological Chemistry (1982)
Shih, T. Y., Journal of Virology 42: 253 (1982). (10.1128/jvi.42.1.253-261.1982) / Journal of Virology (1982)
SHIH, T.Y., GUANINE NUCLEOTIDE-BINDING AND AUTOPHOSPHORYLATING ACTIVITIES ASSOCIATED WITH THE P21SRC PROTEIN OF HARVEY MURINE SARCOMA-VIRUS, NATURE 287: 686 (1980). (10.1038/287686a0) / NATURE (1980)
SHIH T.Y. unpublished data.
SHIH, T.Y., IDENTIFICATION OF A SARCOMA VIRUS-CODED PHOSPHOPROTEIN IN NONPRODUCER CELLS TRANSFORMED BY KIRSTEN OR HARVEY MURINE SARCOMA-VIRUS, VIROLOGY 96: 64 (1979). (10.1016/0042-6822(79)90173-9) / VIROLOGY (1979)
10.1126/science.6287573
WILLIAMSON B unpublished data.

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:51 p.m.)
Indexed	4 weeks, 2 days ago (July 26, 2025, 4:52 a.m.)
Issued	42 years, 11 months ago (Sept. 3, 1982)
Published	42 years, 11 months ago (Sept. 3, 1982)
Published Print	42 years, 11 months ago (Sept. 3, 1982)

Funders 0

None

BibTeX

@article{Dhar_1982, title={Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus}, volume={217}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6287572}, DOI={10.1126/science.6287572}, number={4563}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Dhar, Ravi and Ellis, Ronald W. and Shih, Thomas Y. and Oroszlan, Stephen and Shapiro, Bruce and Maizel, Jacob and Lowy, Douglas and Scolnick, Edward}, year={1982}, month=sep, pages={934–936} }

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