DOI: 10.1126/science.6267699. Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

10.1126/science.6267699

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphin-like immunoactivities by cultured anterior pituitary cells has been purified from ovine hypothalamic extracts. The primary structure of this 41-residue corticotropin- and β-endorphin-releasing factor has been determined to be: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH 2 . The synthetic peptide is active in vitro and in vivo.

Bibliography

Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981). Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and Î²-Endorphin. Science, 213(4514), 1394â1397.

Authors 4

Wylie Vale (first)
Joachim Spiess (additional)
Catherine Rivier (additional)
Jean Rivier (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 6:07 p.m.)
Indexed	1 day, 12 hours ago (Sept. 4, 2025, 10:26 a.m.)
Issued	43 years, 11 months ago (Sept. 18, 1981)
Published	43 years, 11 months ago (Sept. 18, 1981)
Published Print	43 years, 11 months ago (Sept. 18, 1981)

Funders 0

None

BibTeX

@article{Vale_1981, title={Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin}, volume={213}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6267699}, DOI={10.1126/science.6267699}, number={4514}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Vale, Wylie and Spiess, Joachim and Rivier, Catherine and Rivier, Jean}, year={1981}, month=sep, pages={1394–1397} }

JSON

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