DOI: 10.1126/science.6199842. A Monoclonal Antibody to Limbic System Neurons

A Monoclonal Antibody to Limbic System Neurons

10.1126/science.6199842

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A monoclonal antibody produced against hippocampal cell membranes labeled the surface of neurons in the rat limbic system. With a few exceptions, all nonlimbic components were unstained. This specific distribution of immunopositive neurons provides strong evidence of molecular specificity among functionally related neurons in the mammalian brain and supports the concept of a limbic system.

Bibliography

Levitt, P. (1984). A Monoclonal Antibody to Limbic System Neurons. Science, 223(4633), 299â301.

Authors 1

Pat Levitt (first)

References 30 Referenced 179

BARNSTABLE, C.J., MONOCLONAL-ANTIBODIES WHICH RECOGNIZE DIFFERENT CELL-TYPES IN THE RAT RETINA, NATURE 286: 231 (1980). (10.1038/286231a0) / NATURE (1980)
BECKSTEAD, R.M., AUTORADIOGRAPHIC EXAMINATION OF CORTICO-CORTICAL AND SUB-CORTICAL PROJECTIONS OF THE MEDIODORSAL-PROJECTION (PREFRONTAL) CORTEX IN THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 184: 43 (1979). (10.1002/cne.901840104) / JOURNAL OF COMPARATIVE NEUROLOGY (1979)
BROCA, P, REV ANTHR 1: 385 (1978). / REV ANTHR (1978)
COHEN, J, A NEURONAL CELL-SURFACE ANTIGEN IS FOUND IN THE CNS BUT NOT IN PERIPHERAL NEURONS, NATURE 291: 421 (1981). (10.1038/291421a0) / NATURE (1981)
GALFRE, G, ANTIBODIES TO MAJOR HISTOCOMPATIBILITY ANTIGENS PRODUCED BY HYBRID CELL LINES, NATURE 266: 550 (1977). (10.1038/266550a0) / NATURE (1977)
HAWKES, R, MONOCLONAL-ANTIBODIES IDENTIFY NOVEL NEURAL ANTIGENS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2410 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
HIRN, M, MOLECULAR HETEROGENEITY AND STRUCTURAL EVOLUTION DURING CEREBELLAR ONTOGENY DETECTED BY MONOCLONAL-ANTIBODY OF THE MOUSE-CELL SURFACE-ANTIGEN BSP-2, BRAIN RESEARCH 265: 87 (1983). (10.1016/0006-8993(83)91337-9) / BRAIN RESEARCH (1983)
KELLEY, A.E., THE AMYGDALOSTRIATAL PROJECTION IN THE RAT - AN ANATOMICAL STUDY BY ANTEROGRADE AND RETROGRADE TRACING METHODS, NEUROSCIENCE 7: 615 (1982). (10.1016/0306-4522(82)90067-7) / NEUROSCIENCE (1982)
KRETTEK, J.E., AMYGDALOID PROJECTIONS TO SUB-CORTICAL STRUCTURES WITHIN BASAL FOREBRAIN AND BRAIN-STEM IN RAT AND CAT, JOURNAL OF COMPARATIVE NEUROLOGY 178: 225 (1978). (10.1002/cne.901780204) / JOURNAL OF COMPARATIVE NEUROLOGY (1978)
KRIEG, WJS, CONNECTIONS OF THE CEREBRAL CORTEX .1. THE ALBINO RAT .A. TOPOGRAPHY OF THE CORTICAL AREAS, JOURNAL OF COMPARATIVE NEUROLOGY 84: 221 (1946). (10.1002/cne.900840205) / JOURNAL OF COMPARATIVE NEUROLOGY (1946)
LAGENAUR, C, NEUROSCI LETT 31: 1811 (1982). / NEUROSCI LETT (1982)
MACLEAN, P.D., SOME PSYCHIATRIC IMPLICATIONS OF PHYSIOLOGICAL STUDIES ON FRONTOTEMPORAL PORTION OF LIMBIC SYSTEM (VISCERAL BRAIN), ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY 4: 407 (1952). (10.1016/0013-4694(52)90073-4) / ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY (1952)
MCKAY R MONOCLONAL ANTIBODIE (1981).
MCKAY, RDG, MONOCLONAL-ANTIBODIES DISTINGUISH ANTIGENICALLY DISCRETE NEURONAL TYPES IN THE VERTEBRATE CENTRAL NERVOUS-SYSTEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 6747 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
MCKEARN T.J. MONOCLONAL ANTIBODIE (1981).
MCLEAN, I.W., PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE - NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 22: 1077 (1974). (10.1177/22.12.1077) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1974)
MIRSKY, R, TETANUS TOXIN - CELL-SURFACE MARKER FOR NEURONS IN CULTURE, BRAIN RESEARCH 148: 251 (1978). (10.1016/0006-8993(78)90399-2) / BRAIN RESEARCH (1978)
NAUTA WJH NEURAL BASIS BEHAVIO (1982).
PALKOVITZ M HDB HYPOTHALAMUS 1 (1979).
PAPEZ, J.W., A proposed mechanism of emotion, ARCHIVES OF NEUROLOGY AND PSYCHIATRY 38: 725 (1937). (10.1001/archneurpsyc.1937.02260220069003) / ARCHIVES OF NEUROLOGY AND PSYCHIATRY (1937)
RILEY, J.N., DIENCEPHALIC AND BRAIN-STEM AFFERENTS TO THE HIPPOCAMPAL-FORMATION OF THE RAT, BRAIN RESEARCH BULLETIN 6: 437 (1981). (10.1016/S0361-9230(81)80014-7) / BRAIN RESEARCH BULLETIN (1981)
ROBERTSON, R.T., A SUB-CORTICAL PATHWAY LINKS SENSORY AND LIMBIC SYSTEMS OF THE FOREBRAIN, NEUROSCIENCE LETTERS 17: 161 (1980). (10.1016/0304-3940(80)90078-6) / NEUROSCIENCE LETTERS (1980)
SCHACHNER M NEUROIMMUNOLOGY (1982).
SCHWABER, J.S., AMYGDALOID AND BASAL FOREBRAIN DIRECT CONNECTIONS WITH THE NUCLEUS OF THE SOLITARY TRACT AND THE DORSAL MOTOR NUCLEUS, JOURNAL OF NEUROSCIENCE 2: 1424 (1982). (10.1523/JNEUROSCI.02-10-01424.1982) / JOURNAL OF NEUROSCIENCE (1982)
STERNBERGER, L.A., NEUROTYPY - REGIONAL INDIVIDUALITY IN RAT-BRAIN DETECTED BY IMMUNOCYTOCHEMISTRY WITH MONOCLONAL-ANTIBODIES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 1326 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
SWANSON, L.W., AUTORADIOGRAPHIC STUDY OF ORGANIZATION OF EFFERENT CONNECTIONS OF HIPPOCAMPAL FORMATION IN RAT, JOURNAL OF COMPARATIVE NEUROLOGY 172: 49 (1977). (10.1002/cne.901720104) / JOURNAL OF COMPARATIVE NEUROLOGY (1977)
Thiery, J. P., Proceedings of the National Academy of Sciences of the United States of America 79: 6737 (1982). / Proceedings of the National Academy of Sciences of the United States of America (1982)
Trisler, G. D., Proceedings of the National Academy of Sciences of the United States of America 78: 2145 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
WYSS, J.M., STUDY OF SUB-CORTICAL AFFERENTS TO THE HIPPOCAMPAL-FORMATION IN THE RAT, NEUROSCIENCE 4: 463 (1979). (10.1016/0306-4522(79)90124-6) / NEUROSCIENCE (1979)
ZIPSER, B, MONOCLONAL-ANTIBODIES DISTINGUISH IDENTIFIABLE NEURONS IN THE LEECH, NATURE 289: 549 (1981). (10.1038/289549a0) / NATURE (1981)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:22 a.m.)
Indexed	1 month ago (July 30, 2025, 10:24 a.m.)
Issued	41 years, 7 months ago (Jan. 20, 1984)
Published	41 years, 7 months ago (Jan. 20, 1984)
Published Print	41 years, 7 months ago (Jan. 20, 1984)

Funders 0

None

BibTeX

@article{Levitt_1984, title={A Monoclonal Antibody to Limbic System Neurons}, volume={223}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6199842}, DOI={10.1126/science.6199842}, number={4633}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Levitt, Pat}, year={1984}, month=jan, pages={299–301} }

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  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1984,
        1,
        20
      ]
    ]
  }
}