DOI: 10.1126/science.6186026. A Nonenzymatic RNA Polymerase Model

10.1126/science.6186026

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Polynucleotide templates containing C (cytidine) as the major component facilitate the synthesis of oligonucleotides from mixtures of the activated mononucleotide derivatives (as indicated by structure 1 in the text). A nucleotide is incorporated into oligomeric products if and only if its complement is present in the template. The reaction has a high fidelity and produces products with mean chain lengths of six to ten nucleotides. Bases other than guanosine are incorporated within oligomers or at their 3′ termini, but rarely at their 5′ termini.

Bibliography

Inoue, T., & Orgel, L. E. (1983). A Nonenzymatic RNA Polymerase Model. Science, 219(4586), 859â862.

Authors 2

T. Inoue (first)
L. E. Orgel (additional)

References 11 Referenced 237

BRIDSON, P.K., CATALYSIS OF ACCURATE POLY(C)-DIRECTED SYNTHESIS OF 3'-5'-LINKED OLIGOGUANYLATES BY ZN2+, JOURNAL OF MOLECULAR BIOLOGY 144: 567 (1980). (10.1016/0022-2836(80)90337-X) / JOURNAL OF MOLECULAR BIOLOGY (1980)
FAKHRAI H unpublished data.
MILES, T., JOURNAL OF MOLECULAR BIOLOGY 162: 219 (1982). (10.1016/0022-2836(82)90170-X) / JOURNAL OF MOLECULAR BIOLOGY (1982)
INOUE, T, SUBSTITUENT CONTROL OF THE POLY(C)-DIRECTED OLIGOMERIZATION OF GUANOSINE 5'-PHOSPHOROIMIDAZOLIDE, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 103: 7666 (1981). (10.1021/ja00415a051) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1981)
INOUE, T, OLIGOMERIZATION OF (GUANOSINE 5'-PHOSPHOR)-2-METHYLIMIDAZOLIDE ON POLY(C) - AN RNA-POLYMERASE MODEL, JOURNAL OF MOLECULAR BIOLOGY 162: 201 (1982). (10.1016/0022-2836(82)90169-3) / JOURNAL OF MOLECULAR BIOLOGY (1982)
LOMANT, A.J., PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY 15: 185 (1975). (10.1016/S0079-6603(08)60120-8) / PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY (1975)
LOHRMANN, R, EFFICIENT CATALYSIS OF POLYCYTIDYLIC ACID DIRECTED OLIGOGUANYLATE FORMATION BY PB-2+, JOURNAL OF MOLECULAR BIOLOGY 142: 555 (1980). (10.1016/0022-2836(80)90263-6) / JOURNAL OF MOLECULAR BIOLOGY (1980)
LOHRMANN, R, STUDIES OF OLIGOADENYLATE FORMATION ON A POLY(U) TEMPLATE, JOURNAL OF MOLECULAR EVOLUTION 12: 237 (1979). (10.1007/BF01732341) / JOURNAL OF MOLECULAR EVOLUTION (1979)
NINIO, J, JOURNAL OF MOLECULAR EVOLUTION 12: 91 (1978). (10.1007/BF01733260) / JOURNAL OF MOLECULAR EVOLUTION (1978)
TAYLOR C unpublished data.
Ts'o, P. O. P., Basic Principles in Nucleic Acid Chemistry: CH6 (1974). / Basic Principles in Nucleic Acid Chemistry (1974)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 10:29 a.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 5:26 a.m.)
Issued	42 years, 6 months ago (Feb. 18, 1983)
Published	42 years, 6 months ago (Feb. 18, 1983)
Published Print	42 years, 6 months ago (Feb. 18, 1983)

Funders 0

None

BibTeX

@article{Inoue_1983, title={A Nonenzymatic RNA Polymerase Model}, volume={219}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6186026}, DOI={10.1126/science.6186026}, number={4586}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Inoue, T. and Orgel, L. E.}, year={1983}, month=feb, pages={859–862} }

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