DOI: 10.1126/science.6186024. Antibodies That React with Predetermined Sites on Proteins

Antibodies That React with Predetermined Sites on Proteins

10.1126/science.6186024

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Contrary to previous predictions, relatively short synthetic peptides that mimic part of a protein sequence are routinely capable of eliciting an antiserum that reacts with the partially mimicked protein. Peptides capable of eliciting protein-reactive serums are frequently represented in the primary sequence of a protein, can be characterized by a set of simple chemical rules, and are confined neither to immunodominant regions of intact proteins nor to the amino or carboxyl terminals. As such, synthetic peptide immunogens are valuable for eliciting reagents with predetermined specificity that can be used for basic research. In addition, some synthetic peptides are capable of mimicking regions of virus proteins and eliciting immune responses in animals that are protective against the viral agents. Such peptides may thus serve as the basis for safe, chemically defined synthetic vaccines.

Bibliography

Sutcliffe, J. G., Shinnick, T. M., Green, N., & Lerner, R. A. (1983). Antibodies That React with Predetermined Sites on Proteins. Science, 219(4585), 660â666.

Authors 4

J. Gregor Sutcliffe (first)
Thomas M. Shinnick (additional)
Nicola Green (additional)
Richard A. Lerner (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 10:31 a.m.)
Indexed	1 year ago (Aug. 9, 2024, 9:33 p.m.)
Issued	42 years, 6 months ago (Feb. 11, 1983)
Published	42 years, 6 months ago (Feb. 11, 1983)
Published Print	42 years, 6 months ago (Feb. 11, 1983)

Funders 0

None

BibTeX

@article{Sutcliffe_1983, title={Antibodies That React with Predetermined Sites on Proteins}, volume={219}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6186024}, DOI={10.1126/science.6186024}, number={4585}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sutcliffe, J. Gregor and Shinnick, Thomas M. and Green, Nicola and Lerner, Richard A.}, year={1983}, month=feb, pages={660–666} }

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