Journey to the Center of the Cell: Role of the Receptosome
10.1126/science.6170111
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Fibroblasts contain a specific internalization pathway that carries hormones as well as some proteins and viruses from the cell surface to the cell interior. Initially, the ligands bind to mobile receptors that are randomly distributed on the cell surface. Next the ligand-receptor complexes are trapped and concentrated in specialized regions of the membrane termed bristle-coated pits. From the pit a smooth-walled vesicle containing the ligand forms and carries the ligand to the cell interior. Because of its role in receptor-mediated endocytosis, this vesicle has been termed a "receptosome."

Bibliography

Pastan, I. H., & Willingham, M. C. (1981). Journey to the Center of the Cell: Role of the Receptosome. Science, 214(4520), 504–509.

Authors 2
  1. Ira H. Pastan (first)
  2. Mark C. Willingham (additional)
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Dates
Type When
Created 18 years, 11 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 11:20 a.m.)
Indexed 2 days, 21 hours ago (Sept. 4, 2025, 10:23 a.m.)
Issued 43 years, 10 months ago (Oct. 30, 1981)
Published 43 years, 10 months ago (Oct. 30, 1981)
Published Print 43 years, 10 months ago (Oct. 30, 1981)
Funders 0

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@article{Pastan_1981, title={Journey to the Center of the Cell: Role of the Receptosome}, volume={214}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6170111}, DOI={10.1126/science.6170111}, number={4520}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pastan, Ira H. and Willingham, Mark C.}, year={1981}, month=oct, pages={504–509} }