Turnover of Inositol Phospholipids and Signal Transduction
10.1126/science.6147898
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Various extracellular informational signals such as those from a group of hormones and some neurotransmitters appear to be passed from the cell surface into the cell interior by two routes, protein kinase C activation and Ca 2+ mobilization. Both routes usually become available as the result of an interaction of a single ligand and a receptor and act synergistically to evoke subsequent cellular responses such as release reactions. The signal-dependent breakdown of inositol phospholipids, particularly phosphatidylinositol bisphosphate, now appears to be a key event for initiating these processes.

Bibliography

Nishizuka, Y. (1984). Turnover of Inositol Phospholipids and Signal Transduction. Science, 225(4668), 1365–1370.

Authors 1
  1. Yasutomi Nishizuka (first)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 10:58 a.m.)
Indexed 4 days ago (Aug. 28, 2025, 8:51 a.m.)
Issued 40 years, 11 months ago (Sept. 21, 1984)
Published 40 years, 11 months ago (Sept. 21, 1984)
Published Print 40 years, 11 months ago (Sept. 21, 1984)
Funders 0

None

@article{Nishizuka_1984, title={Turnover of Inositol Phospholipids and Signal Transduction}, volume={225}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6147898}, DOI={10.1126/science.6147898}, number={4668}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Nishizuka, Yasutomi}, year={1984}, month=sep, pages={1365–1370} }