Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines
10.1126/science.6101294
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Investigation of the actions of the benzodiazepines has provided insights into the neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation. Behavioral, electrophysiological, pharmacological, and biochemical evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain. The benzodiazepine receptor interacts with a receptor for γ-aminobutyric acid, a major inhibitory neurotransmitter, and enhances its inhibitory effects. The benzodiazepine receptor may also interact with endogenous substances and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Both the purines and nicotinamide possess some benzodiazepine-like properties in vivo, although further work will be required to confirm their possible roles as endogenous benzodiazepines.

Bibliography

Tallman, J. F., Paul, S. M., Skolnick, P., & Gallager, D. W. (1980). Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines. Science, 207(4428), 274–281.

Authors 4
  1. John F. Tallman (first)
  2. Steven M. Paul (additional)
  3. Phil Skolnick (additional)
  4. Dorothy W. Gallager (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 1:45 p.m.)
Deposited 7 months, 3 weeks ago (Jan. 11, 2025, 1:48 a.m.)
Indexed 1 month ago (July 30, 2025, 11:17 a.m.)
Issued 45 years, 7 months ago (Jan. 18, 1980)
Published 45 years, 7 months ago (Jan. 18, 1980)
Published Print 45 years, 7 months ago (Jan. 18, 1980)
Funders 0

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@article{Tallman_1980, title={Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines}, volume={207}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.6101294}, DOI={10.1126/science.6101294}, number={4428}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tallman, John F. and Paul, Steven M. and Skolnick, Phil and Gallager, Dorothy W.}, year={1980}, month=jan, pages={274–281} }