DOI: 10.1126/science.569901. In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle

In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle

10.1126/science.569901

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Mechanical stretch of embryonic chicken skeletal myotubes developed in vitro leads to many of the biochemical changes seen in skeletal muscle hypertrophy. These include increased amino acid accumulation, increased incorporation of amino acids into general cellular proteins and myosin heavy chains, and increased accumulation of total protein and myosin heavy chains. This model system should aid in understanding how the growth rate of skeletal muscle is regulated by its activity.

Bibliography

Vandenburgh, H., & Kaufman, S. (1979). In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle. Science, 203(4377), 265â268.

Authors 2

Herman Vandenburgh (first)
Seymour Kaufman (additional)

References 35 Referenced 198

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ELSAS, L.J., AMINO-ACID TRANSPORT BY AGGREGATES OF CULTURED CHICKEN HEART-CELLS - EFFECT OF INSULIN, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 9381 (1975). (10.1016/S0021-9258(19)40655-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
EMERSON, C.P., ACTIVATION OF MYOSIN SYNTHESIS IN FUSING AND MONONUCLEATED MYOBLASTS, JOURNAL OF MOLECULAR BIOLOGY 93: 431 (1975). (10.1016/0022-2836(75)90238-7) / JOURNAL OF MOLECULAR BIOLOGY (1975)
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FLECKMAN P UNPUBLISHED.
GOLDBERG, A.L., WORK-INDUCED GROWTH OF SKELETAL MUSCLE IN NORMAL AND HYPOPHYSECTOMIZED RATS, AMERICAN JOURNAL OF PHYSIOLOGY 213: 1193 (1967). (10.1152/ajplegacy.1967.213.5.1193) / AMERICAN JOURNAL OF PHYSIOLOGY (1967)
GOLDBERG, A.L., AMINO ACID TRANSPORT DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE, AMERICAN JOURNAL OF PHYSIOLOGY 216: 1111 (1969). (10.1152/ajplegacy.1969.216.5.1111) / AMERICAN JOURNAL OF PHYSIOLOGY (1969)
GOLDBERG, A.L., CARDIAC HYPERTROPHY: 301 (1971). / CARDIAC HYPERTROPHY (1971)
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GOLDBERG, A.L., MECHANISM OF WORK-INDUCED HYPERTROPHY OF SKELETAL-MUSCLE, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 7: 248 (1975). / MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (1975)
GOLDSPINK, G, EFFECT OF DENERVATION ON ADAPTATION OF SARCOMERE NUMBER AND MUSCLE EXTENSIBILITY TO FUNCTIONAL LENGTH OF MUSCLE, JOURNAL OF PHYSIOLOGY-LONDON 236: 733 (1974). (10.1113/jphysiol.1974.sp010463) / JOURNAL OF PHYSIOLOGY-LONDON (1974)
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MEYERHOF, O, The isometric coefficients of oxygen of normal and iodacetic acid poisoned muscles., BIOCHEMISCHE ZEITSCHRIFT 258: 371 (1933). / BIOCHEMISCHE ZEITSCHRIFT (1933)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 11:16 a.m.)
Indexed	1 month, 2 weeks ago (July 16, 2025, 8:05 a.m.)
Issued	46 years, 7 months ago (Jan. 19, 1979)
Published	46 years, 7 months ago (Jan. 19, 1979)
Published Print	46 years, 7 months ago (Jan. 19, 1979)

Funders 0

None

BibTeX

@article{Vandenburgh_1979, title={In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle}, volume={203}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.569901}, DOI={10.1126/science.569901}, number={4377}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Vandenburgh, Herman and Kaufman, Seymour}, year={1979}, month=jan, pages={265–268} }

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