DOI: 10.1126/science.505015. A Direct Role of Dopamine in the Rat Subthalamic Nucleus and an Adjacent Intrapeduncular Area

A Direct Role of Dopamine in the Rat Subthalamic Nucleus and an Adjacent Intrapeduncular Area

10.1126/science.505015

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.

Bibliography

Brown, L. L., Markman, M. H., Wolfson, L. I., Dvorkin, B., Warner, C., & Katzman, R. (1979). A Direct Role of Dopamine in the Rat Subthalamic Nucleus and an Adjacent Intrapeduncular Area. Science, 206(4425), 1416â1418.

Authors 6

Lucy L. Brown (first)
Maynard H. Markman (additional)
Leslie I. Wolfson (additional)
B. Dvorkin (additional)
Carolyn Warner (additional)
Robert Katzman (additional)

References 23 Referenced 66

AHN, H.S., CATECHOLAMINE-SENSITIVE ADENYLATE-CYCLASE IN FRONTAL CORTEX OF PRIMATE BRAIN, BRAIN RESEARCH 116: 437 (1976). (10.1016/0006-8993(76)90492-3) / BRAIN RESEARCH (1976)
BROWN, L.L., APOMORPHINE INCREASES GLUCOSE-UTILIZATION IN SUBSTANTIA NIGRA, SUBTHALAMIC NUCLEUS AND CORPUS STRIATUM OF RAT, BRAIN RESEARCH 140: 188 (1978). (10.1016/0006-8993(78)90251-2) / BRAIN RESEARCH (1978)
Carpenter, M. B., Pathogenesis and Treatment of Parkinsonism: 50 (1978). / Pathogenesis and Treatment of Parkinsonism (1978)
FONNUM, F, ORIGIN AND DISTRIBUTION OF GLUTAMATE DECARBOXYLASE IN NUCLEUS SUBTHALAMICUS OF CAT, BRAIN RESEARCH 153: 370 (1978). (10.1016/0006-8993(78)90417-1) / BRAIN RESEARCH (1978)
FONNUM, F, DISTRIBUTION OF GLUTAMATE DECARBOXYLASE, CHOLINE-ACETYLTRANSFERASE AND AROMATIC AMINO-ACID DECARBOXYLASE IN BASAL GANGLIA OF NORMAL AND OPERATED RATS - EVIDENCE FOR STRIATO-PALLIDAL, STRIATO-ENTOPEDUNCULAR AND STRIATONIGRAL GABAERGIC FIBERS, BRAIN RESEARCH 143: 125 (1978). (10.1016/0006-8993(78)90756-4) / BRAIN RESEARCH (1978)
FUXE K ACTA PHYSIOLOGICA SCANDINAVICA 64 247 (1965). (10.1111/j.1748-1716.1965.tb04155.x)
10.1126/science.13499
10.1126/science.2976
IWAHORI, N, GOLGI STUDY ON SUBTHALAMIC NUCLEUS OF CAT, JOURNAL OF COMPARATIVE NEUROLOGY 182: 383 (1978). (10.1002/cne.901820303) / JOURNAL OF COMPARATIVE NEUROLOGY (1978)
JOHNSON, W.G., TREATMENT OF VASCULAR HEMIBALLISM AND HEMICHOREA, NEUROLOGY 27: 634 (1977). (10.1212/WNL.27.7.634) / NEUROLOGY (1977)
KATZMAN, R, REINNERVATION, MYELINATION AND ORGANIZATION OF IRIS TISSUE IMPLANTED INTO RAT MIDBRAIN - ULTRASTRUCTURAL-STUDY, BRAIN RESEARCH 138: 423 (1977). (10.1016/0006-8993(77)90682-5) / BRAIN RESEARCH (1977)
KLAWANS, H.L., TREATMENT AND PROGNOSIS OF HEMIBALLISMUS, NEW ENGLAND JOURNAL OF MEDICINE 295: 1348 (1976). (10.1056/NEJM197612092952404) / NEW ENGLAND JOURNAL OF MEDICINE (1976)
Kuzemensky, J., Folia Morphologica 23: 182 (1975). / Folia Morphologica (1975)
LINDVALL, O, ORGANIZATION OF CATECHOLAMINE NEURONS PROJECTING TO FRONTAL CORTEX IN RAT, BRAIN RESEARCH 142: 1 (1978). (10.1016/0006-8993(78)90173-7) / BRAIN RESEARCH (1978)
LINDVALL, O, GLYOXYLIC-ACID FLUORESCENCE HISTOCHEMICAL METHOD - A DETAILED ACCOUNT OF METHODOLOGY FOR VISUALIZATION OF CENTRAL CATECHOLAMINE NEURONS, HISTOCHEMISTRY 39: 97 (1974). (10.1007/BF00492041) / HISTOCHEMISTRY (1974)
Makman, M. H., Biochemical Actions of Hormones 4: 407 (1977). / Biochemical Actions of Hormones (1977)
MEIBACH, R.C., CATECHOLAMINERGIC INNERVATION OF THE SUBTHALAMIC NUCLEUS - EVIDENCE FOR A ROSTRAL CONTINUATION OF THE A9 (SUBSTANTIA-NIGRA) DOPAMINERGIC CELL GROUP, BRAIN RESEARCH 173: 364 (1979). (10.1016/0006-8993(79)90639-5) / BRAIN RESEARCH (1979)
REUBI, J.C., DOPAMINE SELECTIVELY INCREASES H-3-GABA RELEASE FROM SLICES OF RAT SUBSTANTIA NIGRA INVITRO, NATURE 268: 652 (1977). (10.1038/268652a0) / NATURE (1977)
Riley, H. A., An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord: 178 (1943). / An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord (1943)
10.1111/j.1471-4159.1977.tb10649.x
VERSTEEG, DHG, REGIONAL CONCENTRATIONS OF NORADRENALINE AND DOPAMINE IN RAT-BRAIN, BRAIN RESEARCH 113: 563 (1976). (10.1016/0006-8993(76)90057-3) / BRAIN RESEARCH (1976)
WHITTIER, J.R., BALLISM AND THE SUBTHALAMIC NUCLEUS (NUCLEUS HYPOTHALAMICUS - CORPUS LUYSI) - REVIEW OF THE LITERATURE AND STUDY OF 30 CASES, ARCHIVES OF NEUROLOGY AND PSYCHIATRY 58: 672 (1947). (10.1001/archneurpsyc.1947.02300350022002) / ARCHIVES OF NEUROLOGY AND PSYCHIATRY (1947)
WHITTIER, J.R., STUDIES ON THE SUBTHALAMUS OF THE RHESUS MONKEY .1. ANATOMY AND FIBER CONNECTIONS OF THE SUBTHALAMIC NUCLEUS OF LUYS, JOURNAL OF COMPARATIVE NEUROLOGY 90: 281 (1949). (10.1002/cne.900900303) / JOURNAL OF COMPARATIVE NEUROLOGY (1949)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 10:53 a.m.)
Indexed	1 week, 6 days ago (Aug. 23, 2025, 1:02 a.m.)
Issued	45 years, 8 months ago (Dec. 21, 1979)
Published	45 years, 8 months ago (Dec. 21, 1979)
Published Print	45 years, 8 months ago (Dec. 21, 1979)

Funders 0

None

BibTeX

@article{Brown_1979, title={A Direct Role of Dopamine in the Rat Subthalamic Nucleus and an Adjacent Intrapeduncular Area}, volume={206}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.505015}, DOI={10.1126/science.505015}, number={4425}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Brown, Lucy L. and Markman, Maynard H. and Wolfson, Leslie I. and Dvorkin, B. and Warner, Carolyn and Katzman, Robert}, year={1979}, month=dec, pages={1416–1418} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T05:02:36Z",
    "timestamp": 1755925356987
  },
  "reference-count": 23,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4425",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1979,
        12,
        21
      ]
    ]
  },
  "abstract": "<jats:p>The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.</jats:p>",
  "DOI": "10.1126/science.505015",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T16:39:42Z",
    "timestamp": 1160066382000
  },
  "page": "1416-1418",
  "source": "Crossref",
  "is-referenced-by-count": 66,
  "title": "A Direct Role of Dopamine in the Rat Subthalamic Nucleus and an Adjacent Intrapeduncular Area",
  "prefix": "10.1126",
  "volume": "206",
  "author": [
    {
      "given": "Lucy L.",
      "family": "Brown",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    },
    {
      "given": "Maynard H.",
      "family": "Markman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    },
    {
      "given": "Leslie I.",
      "family": "Wolfson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    },
    {
      "given": "B.",
      "family": "Dvorkin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    },
    {
      "given": "Carolyn",
      "family": "Warner",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    },
    {
      "given": "Robert",
      "family": "Katzman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Neurology, Biochemistry, and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461"
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1016/0006-8993(76)90492-3",
      "volume": "116",
      "year": "1976",
      "unstructured": "AHN, H.S., CATECHOLAMINE-SENSITIVE ADENYLATE-CYCLASE IN FRONTAL CORTEX OF PRIMATE BRAIN, BRAIN RESEARCH 116: 437 (1976).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1016/0006-8993(78)90251-2",
      "volume": "140",
      "year": "1978",
      "unstructured": "BROWN, L.L., APOMORPHINE INCREASES GLUCOSE-UTILIZATION IN SUBSTANTIA NIGRA, SUBTHALAMIC NUCLEUS AND CORPUS STRIATUM OF RAT, BRAIN RESEARCH 140: 188 (1978).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "50",
      "year": "1978",
      "unstructured": "Carpenter, M. B., Pathogenesis and Treatment of Parkinsonism: 50 (1978).",
      "journal-title": "Pathogenesis and Treatment of Parkinsonism"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1016/0006-8993(78)90417-1",
      "volume": "153",
      "year": "1978",
      "unstructured": "FONNUM, F, ORIGIN AND DISTRIBUTION OF GLUTAMATE DECARBOXYLASE IN NUCLEUS SUBTHALAMICUS OF CAT, BRAIN RESEARCH 153: 370 (1978).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1016/0006-8993(78)90756-4",
      "volume": "143",
      "year": "1978",
      "unstructured": "FONNUM, F, DISTRIBUTION OF GLUTAMATE DECARBOXYLASE, CHOLINE-ACETYLTRANSFERASE AND AROMATIC AMINO-ACID DECARBOXYLASE IN BASAL GANGLIA OF NORMAL AND OPERATED RATS - EVIDENCE FOR STRIATO-PALLIDAL, STRIATO-ENTOPEDUNCULAR AND STRIATONIGRAL GABAERGIC FIBERS, BRAIN RESEARCH 143: 125 (1978).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "unstructured": "FUXE K ACTA PHYSIOLOGICA SCANDINAVICA 64 247 (1965).",
      "DOI": "10.1111/j.1748-1716.1965.tb04155.x"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.13499"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2976"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1002/cne.901820303",
      "volume": "182",
      "year": "1978",
      "unstructured": "IWAHORI, N, GOLGI STUDY ON SUBTHALAMIC NUCLEUS OF CAT, JOURNAL OF COMPARATIVE NEUROLOGY 182: 383 (1978).",
      "journal-title": "JOURNAL OF COMPARATIVE NEUROLOGY"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1212/WNL.27.7.634",
      "volume": "27",
      "year": "1977",
      "unstructured": "JOHNSON, W.G., TREATMENT OF VASCULAR HEMIBALLISM AND HEMICHOREA, NEUROLOGY 27: 634 (1977).",
      "journal-title": "NEUROLOGY"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1016/0006-8993(77)90682-5",
      "volume": "138",
      "year": "1977",
      "unstructured": "KATZMAN, R, REINNERVATION, MYELINATION AND ORGANIZATION OF IRIS TISSUE IMPLANTED INTO RAT MIDBRAIN - ULTRASTRUCTURAL-STUDY, BRAIN RESEARCH 138: 423 (1977).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "1348",
      "DOI": "10.1056/NEJM197612092952404",
      "volume": "295",
      "year": "1976",
      "unstructured": "KLAWANS, H.L., TREATMENT AND PROGNOSIS OF HEMIBALLISMUS, NEW ENGLAND JOURNAL OF MEDICINE 295: 1348 (1976).",
      "journal-title": "NEW ENGLAND JOURNAL OF MEDICINE"
    },
    {
      "key": "e_1_2_1_13_1",
      "first-page": "182",
      "volume": "23",
      "year": "1975",
      "unstructured": "Kuzemensky, J., Folia Morphologica 23: 182 (1975).",
      "journal-title": "Folia Morphologica"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0006-8993(78)90173-7",
      "volume": "142",
      "year": "1978",
      "unstructured": "LINDVALL, O, ORGANIZATION OF CATECHOLAMINE NEURONS PROJECTING TO FRONTAL CORTEX IN RAT, BRAIN RESEARCH 142: 1 (1978).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1007/BF00492041",
      "volume": "39",
      "year": "1974",
      "unstructured": "LINDVALL, O, GLYOXYLIC-ACID FLUORESCENCE HISTOCHEMICAL METHOD - A DETAILED ACCOUNT OF METHODOLOGY FOR VISUALIZATION OF CENTRAL CATECHOLAMINE NEURONS, HISTOCHEMISTRY 39: 97 (1974).",
      "journal-title": "HISTOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_16_1",
      "first-page": "407",
      "volume": "4",
      "year": "1977",
      "unstructured": "Makman, M. H., Biochemical Actions of Hormones 4: 407 (1977).",
      "journal-title": "Biochemical Actions of Hormones"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "364",
      "DOI": "10.1016/0006-8993(79)90639-5",
      "volume": "173",
      "year": "1979",
      "unstructured": "MEIBACH, R.C., CATECHOLAMINERGIC INNERVATION OF THE SUBTHALAMIC NUCLEUS - EVIDENCE FOR A ROSTRAL CONTINUATION OF THE A9 (SUBSTANTIA-NIGRA) DOPAMINERGIC CELL GROUP, BRAIN RESEARCH 173: 364 (1979).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "652",
      "DOI": "10.1038/268652a0",
      "volume": "268",
      "year": "1977",
      "unstructured": "REUBI, J.C., DOPAMINE SELECTIVELY INCREASES H-3-GABA RELEASE FROM SLICES OF RAT SUBSTANTIA NIGRA INVITRO, NATURE 268: 652 (1977).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_19_1",
      "first-page": "178",
      "year": "1943",
      "unstructured": "Riley, H. A., An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord: 178 (1943).",
      "journal-title": "An Atlas of the Basal Ganglia, Brain Stem and Spinal Cord"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1977.tb10649.x"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1016/0006-8993(76)90057-3",
      "volume": "113",
      "year": "1976",
      "unstructured": "VERSTEEG, DHG, REGIONAL CONCENTRATIONS OF NORADRENALINE AND DOPAMINE IN RAT-BRAIN, BRAIN RESEARCH 113: 563 (1976).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1001/archneurpsyc.1947.02300350022002",
      "volume": "58",
      "year": "1947",
      "unstructured": "WHITTIER, J.R., BALLISM AND THE SUBTHALAMIC NUCLEUS (NUCLEUS HYPOTHALAMICUS - CORPUS LUYSI) - REVIEW OF THE LITERATURE AND STUDY OF 30 CASES, ARCHIVES OF NEUROLOGY AND PSYCHIATRY 58: 672 (1947).",
      "journal-title": "ARCHIVES OF NEUROLOGY AND PSYCHIATRY"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1002/cne.900900303",
      "volume": "90",
      "year": "1949",
      "unstructured": "WHITTIER, J.R., STUDIES ON THE SUBTHALAMUS OF THE RHESUS MONKEY .1. ANATOMY AND FIBER CONNECTIONS OF THE SUBTHALAMIC NUCLEUS OF LUYS, JOURNAL OF COMPARATIVE NEUROLOGY 90: 281 (1949).",
      "journal-title": "JOURNAL OF COMPARATIVE NEUROLOGY"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.505015",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        14
      ]
    ],
    "date-time": "2024-01-14T15:53:36Z",
    "timestamp": 1705247616000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.505015"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1979,
        12,
        21
      ]
    ]
  },
  "references-count": 23,
  "journal-issue": {
    "issue": "4425",
    "published-print": {
      "date-parts": [
        [
          1979,
          12,
          21
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.505015"
  ],
  "URL": "http://dx.doi.org/10.1126/science.505015",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1979,
        12,
        21
      ]
    ]
  }
}