DOI: 10.1126/science.49080. Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport

Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport

10.1126/science.49080

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125 I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.

Bibliography

Price, D. L., Griffin, J., Young, A., Peck, K., & Stocks, A. (1975). Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport. Science, 188(4191), 945â947.

Authors 5

Donald L. Price (first)
Jack Griffin (additional)
Ann Young (additional)
Keith Peck (additional)
Adelaine Stocks (additional)

References 35 Referenced 193

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:11 a.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 10:48 a.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 11:31 a.m.)
Issued	50 years, 3 months ago (May 30, 1975)
Published	50 years, 3 months ago (May 30, 1975)
Published Print	50 years, 3 months ago (May 30, 1975)

Funders 0

None

BibTeX

@article{Price_1975, title={Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport}, volume={188}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.49080}, DOI={10.1126/science.49080}, number={4191}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Price, Donald L. and Griffin, Jack and Young, Ann and Peck, Keith and Stocks, Adelaine}, year={1975}, month=may, pages={945–947} }

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