Regulation of Gene Expression: Possible Role of Repetitive Sequences
10.1126/science.451548
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Large contrasts are observed between the messenger RNA populations of different tissues and of embryos at different stages of development. Nevertheless, coding sequences for genes not expressed in a cell appear to be present in its nuclear RNA. Though many nuclear RNA transcripts of single copy DNA sequences are held in common between tissues, an additional set, probably consisting of non-message sequences, is not shared. Nuclear RNA also contains transcripts of repetitive DNA sequences. Certain repeat families are represented at high levels in the nuclear RNA of particular tissues and much lower levels in others. It is surprising that both complements of most repeat sequences are present in nuclear RNA. These observations lead to a model for regulation of gene expression in which the formation of repetitive RNA-RNA duplexes controls the production of messenger RNA.

Bibliography

Davidson, E. H., & Britten, R. J. (1979). Regulation of Gene Expression: Possible Role of Repetitive Sequences. Science, 204(4397), 1052–1059.

Authors 2
  1. Eric H. Davidson (first)
  2. Roy J. Britten (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited 1 year, 7 months ago (Jan. 14, 2024, 4:56 a.m.)
Indexed 1 month, 2 weeks ago (July 12, 2025, 6:44 p.m.)
Issued 46 years, 2 months ago (June 8, 1979)
Published 46 years, 2 months ago (June 8, 1979)
Published Print 46 years, 2 months ago (June 8, 1979)
Funders 0

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@article{Davidson_1979, title={Regulation of Gene Expression: Possible Role of Repetitive Sequences}, volume={204}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.451548}, DOI={10.1126/science.451548}, number={4397}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Davidson, Eric H. and Britten, Roy J.}, year={1979}, month=jun, pages={1052–1059} }