DOI: 10.1126/science.4023698. The Structure of Arthropod Hemocyanins

10.1126/science.4023698

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Hemocyanins are large multi-subunit copper proteins that transport oxygen in many arthropods and molluscs. Comparison of the amino acid sequence data for seven different subunits of arthropod hemocyanins from crustaceans and chelicerates shows many highly conserved residues and extensive regions of near identity. This correspondence can be matched closely with the three domain structure established by x-ray crystallography for spiny lobster hemocyanin. The degree of identity is particularly striking in the second domain of the subunit that contains the six histidines which ligate the two oxygen-binding copper atoms. The polypeptide architecture of spiny lobster hemocyanin appears to be the same in all arthropods. This structure must therefore be at least as old as the estimated time of divergence of crustaceans and chelicerates, about 540 to 600 million years ago.

Bibliography

Linzen, B., Soeter, N. M., Riggs, A. F., Schneider, H.-J., Schartau, W., Moore, M. D., Yokota, E., Behrens, P. Q., Nakashima, H., Takagi, T., Nemoto, T., Vereijken, J. M., Bak, H. J., Beintema, J. J., Volbeda, A., Gaykema, W. P. J., & Hol, W. G. J. (1985). The Structure of Arthropod Hemocyanins. Science, 229(4713), 519â524.

Authors 17

B. Linzen (first)
N. M. Soeter (additional)
A. F. Riggs (additional)
H.-J. Schneider (additional)
W. Schartau (additional)
M. D. Moore (additional)
E. Yokota (additional)
P. Q. Behrens (additional)
H. Nakashima (additional)
T. Takagi (additional)
T. Nemoto (additional)
J. M. Vereijken (additional)
H. J. Bak (additional)
J. J. Beintema (additional)
A. Volbeda (additional)
W. P. J. Gaykema (additional)
W. G. J. Hol (additional)

References 31 Referenced 192

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Bergstrom, J., Arthropod Phylogeny: 3 (1979). / Arthropod Phylogeny (1979)
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KEMPTER, B, IMMUNOLOGICAL CORRESPONDENCE BETWEEN ARTHROPOD HEMOCYANIN SUBUNITS .2. XIPHOSURAN (LIMULUS) AND SPIDER (EURYPELMA, CUPIENNIUS) HEMOCYANIN, HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 366: 77 (1985). / HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE (1985)
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LOEWE, R, HEMOCYANINS IN SPIDERS .5. FLUORIMETRIC RECORDING OF OXYGEN BINDING CURVES, AND ITS APPLICATION TO ANALYSIS OF ALLOSTERIC INTERACTIONS IN EURYPELMA-CALIFORNICUM HEMOCYANIN, JOURNAL OF COMPARATIVE PHYSIOLOGY 128: 161 (1978). (10.1007/BF00689480) / JOURNAL OF COMPARATIVE PHYSIOLOGY (1978)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:16 a.m.)
Indexed	1 week, 1 day ago (Aug. 23, 2025, 9:17 p.m.)
Issued	40 years ago (Aug. 9, 1985)
Published	40 years ago (Aug. 9, 1985)
Published Print	40 years ago (Aug. 9, 1985)

Funders 0

None

BibTeX

@article{Linzen_1985, title={The Structure of Arthropod Hemocyanins}, volume={229}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.4023698}, DOI={10.1126/science.4023698}, number={4713}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Linzen, B. and Soeter, N. M. and Riggs, A. F. and Schneider, H.-J. and Schartau, W. and Moore, M. D. and Yokota, E. and Behrens, P. Q. and Nakashima, H. and Takagi, T. and Nemoto, T. and Vereijken, J. M. and Bak, H. J. and Beintema, J. J. and Volbeda, A. and Gaykema, W. P. J. and Hol, W. G. J.}, year={1985}, month=aug, pages={519–524} }

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