DOI: 10.1126/science.4012312. Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals

Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals

10.1126/science.4012312

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Brain dopamine is necessary for normal movement. To determine whether there is a precise relation between the intensity of movement and changes in brain dopamine metabolism, the investigators ran rats on straight and circular treadmills at different speeds and with different body postures. Concentrations of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid increased in the caudate and accumbens nuclei in direct relation to the speed and angular posture of the animals. Dopamine metabolism in the nucleus accumbens was more strongly linked to the speed and direction of movement, while in the caudate nucleus dopamine and 3,4-dihydroxyphenylacetic acid were affected most by posture and direction.

Bibliography

Freed, C. R., & Yamamoto, B. K. (1985). Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals. Science, 229(4708), 62â65.

Authors 2

Curt R. Freed (first)
Bryan K. Yamamoto (additional)

References 29 Referenced 151

ANDEN, N.E., FUNCTIONAL ROLE OF NIGRO-NEOSTRIATAL DOPAMINE NEURONS, ACTA PHARMACOLOGICA ET TOXICOLOGICA 24: 263 (1966). (10.1111/j.1600-0773.1966.tb00389.x) / ACTA PHARMACOLOGICA ET TOXICOLOGICA (1966)
Anden, N.-E., Mechanism of Release of Biogenic Amines: 357 (1966). / Mechanism of Release of Biogenic Amines (1966)
ARBUTHNOTT, G.W., ACTA PHYSIOLOGICA SCANDINAVICA 330: 117 (1969). / ACTA PHYSIOLOGICA SCANDINAVICA (1969)
BARNETT, A, HEAD-TURNING INDUCED BY ELECTRICAL-STIMULATION OF CAUDATE-NUCLEUS AND ITS ANTAGONISM BY ANTI-PARKINSON DRUGS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 194: 296 (1975). / JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1975)
10.1016/0006-8993(79)90472-4
COSTALL, B, DESIGN OF AGENTS FOR STIMULATION OF NEOSTRIATAL DOPAMINERGIC MECHANISMS, JOURNAL OF PHARMACY AND PHARMACOLOGY 26: 753 (1974). (10.1111/j.2042-7158.1974.tb09170.x) / JOURNAL OF PHARMACY AND PHARMACOLOGY (1974)
COTZIAS, G.C., AROMATIC AMINO ACIDS AND MODIFICATION OF PARKINSONISM, NEW ENGLAND JOURNAL OF MEDICINE 276: 374 (1967). (10.1056/NEJM196702162760703) / NEW ENGLAND JOURNAL OF MEDICINE (1967)
CROSSMAN, A.R., EFFECTS OF MANIPULATING PALLIDAL AND NIGRAL GABA ON STRIATALLY-MEDIATED HEAD-TURNING IN RAT, BRITISH JOURNAL OF PHARMACOLOGY 61: P483 (1977). / BRITISH JOURNAL OF PHARMACOLOGY (1977)
DUNNETT, S.B., ACTA PHYSIOLOGICA SCANDINAVICA 522: 29 (1983). / ACTA PHYSIOLOGICA SCANDINAVICA (1983)
EHRINGER, H, VERTEILUNG VON NORADRENALIN UND DOPAMIN (3-HYDROXYTYRAMIN) IM GEHIRN DES MENSCHEN UND IHR VERHALTEN BEI ERKRANKUNGEN DES EXTRAPYRAMIDALEN SYSTEMS, KLINISCHE WOCHENSCHRIFT 38: 1236 (1960). (10.1007/BF01485901) / KLINISCHE WOCHENSCHRIFT (1960)
FREED, C. R., Dopamine Release from Left and Right Caudate of the Rat Measured by in vivo Electrochemical Electrodes, ADVANCES IN THE BIOSCIENCES 37: 243 (1982). / ADVANCES IN THE BIOSCIENCES / Dopamine Release from Left and Right Caudate of the Rat Measured by in vivo Electrochemical Electrodes (1982)
FREED, C.R., BRAIN-TISSUE AND PLASMA ASSAY OF L-DOPA AND ALPHA-METHYLDOPA METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION, JOURNAL OF NEUROCHEMISTRY 32: 163 (1979). (10.1111/j.1471-4159.1979.tb04523.x) / JOURNAL OF NEUROCHEMISTRY (1979)
FREED, W.J., RESTORATION OF DOPAMINERGIC FUNCTION BY GRAFTING OF FETAL-RAT SUBSTANTIA NIGRA TO THE CAUDATE-NUCLEUS - LONG-TERM BEHAVIORAL, BIOCHEMICAL, AND HISTOCHEMICAL-STUDIES, ANNALS OF NEUROLOGY 8: 510 (1980). (10.1002/ana.410080508) / ANNALS OF NEUROLOGY (1980)
JONES, D.L., NUCLEUS ACCUMBENS TO GLOBUS PALLIDUS GABA PROJECTION SUBSERVING AMBULATORY ACTIVITY, AMERICAN JOURNAL OF PHYSIOLOGY 238: R65 (1980). / AMERICAN JOURNAL OF PHYSIOLOGY (1980)
KELLY, P.H., AMPHETAMINE AND APOMORPHINE RESPONSES IN RAT FOLLOWING 6-OHDA LESIONS OF NUCLEUS ACCUMBENS SEPTI AND CORPUS STRIATUM, BRAIN RESEARCH 94: 507 (1975). (10.1016/0006-8993(75)90233-4) / BRAIN RESEARCH (1975)
KELLY, P.H., UNILATERAL 6-HYDROXYDOPAMINE LESIONS OF NIGROSTRIATAL OR MESOLIMBIC DOPAMINE-CONTAINING TERMINALS AND DRUG-INDUCED ROTATION OF RATS, BRAIN RESEARCH 100: 163 (1975). (10.1016/0006-8993(75)90253-X) / BRAIN RESEARCH (1975)
KELLY, P.H., SELECTIVE 6OHDA-INDUCED DESTRUCTION OF MESOLIMBIC DOPAMINE NEURONS - ABOLITION OF PSYCHOSTIMULANT-INDUCED LOCOMOTOR-ACTIVITY IN RATS, EUROPEAN JOURNAL OF PHARMACOLOGY 40: 45 (1976). (10.1016/0014-2999(76)90352-6) / EUROPEAN JOURNAL OF PHARMACOLOGY (1976)
MORGAN, M.E., UNILATERAL ACTIVATION OF CAUDATE TYROSINE-HYDROXYLASE DURING VOLUNTARY CIRCLING BEHAVIOR, JOURNAL OF NEUROCHEMISTRY 43: 737 (1984). (10.1111/j.1471-4159.1984.tb12794.x) / JOURNAL OF NEUROCHEMISTRY (1984)
Paxinos G. The Rat Brain in Stereotaxic Coordinates (1982).
10.1126/science.571147
PIJNENBURG, AJJ, EFFECTS OF CHEMICAL STIMULATION OF MESOLIMBIC DOPAMINE SYSTEM UPON LOCOMOTOR ACTIVITY, EUROPEAN JOURNAL OF PHARMACOLOGY 35: 45 (1976). (10.1016/0014-2999(76)90299-5) / EUROPEAN JOURNAL OF PHARMACOLOGY (1976)
PIJNENBURG, AJJ, STIMULATION OF LOCOMOTOR ACTIVITY FOLLOWING INJECTION OF DOPAMINE INTO NUCLEUS ACCUMBENS, JOURNAL OF PHARMACY AND PHARMACOLOGY 25: 1003 (1973). (10.1111/j.2042-7158.1973.tb09995.x) / JOURNAL OF PHARMACY AND PHARMACOLOGY (1973)
PYCOCK, C.J., ROTATING RODENT - 2 COMPONENT SYSTEM, EUROPEAN JOURNAL OF PHARMACOLOGY 47: 167 (1978). (10.1016/0014-2999(78)90388-6) / EUROPEAN JOURNAL OF PHARMACOLOGY (1978)
SCHMIDT, R.H., ACTA PHYSIOLOGICA SCANDINAVICA 522: 19 (1983). / ACTA PHYSIOLOGICA SCANDINAVICA (1983)
UNGERSTEDT, U, DIRECT CHEMICAL STIMULATION OF DOPAMINERGIC MECHANISMS IN NEOSTRIATUM OF RAT, BRAIN RESEARCH 14: 461 (1969). (10.1016/0006-8993(69)90122-X) / BRAIN RESEARCH (1969)
YAMAMOTO, B.K., ASYMMETRIC DOPAMINE AND SEROTONIN METABOLISM IN NIGROSTRIATAL AND LIMBIC STRUCTURES OF THE TRAINED CIRCLING RAT, BRAIN RESEARCH 297: 115 (1984). (10.1016/0006-8993(84)90547-X) / BRAIN RESEARCH (1984)
YAMAMOTO, B.K., NORMAL RATS TRAINED TO CIRCLE SHOW ASYMMETRIC CAUDATE DOPAMINE RELEASE, LIFE SCIENCES 30: 2155 (1982). (10.1016/0024-3205(82)90289-2) / LIFE SCIENCES (1982)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 11, 2025, 2:28 a.m.)
Indexed	4 days, 21 hours ago (Aug. 27, 2025, 12:29 p.m.)
Issued	40 years, 1 month ago (July 5, 1985)
Published	40 years, 1 month ago (July 5, 1985)
Published Print	40 years, 1 month ago (July 5, 1985)

Funders 0

None

BibTeX

@article{Freed_1985, title={Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals}, volume={229}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.4012312}, DOI={10.1126/science.4012312}, number={4708}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Freed, Curt R. and Yamamoto, Bryan K.}, year={1985}, month=jul, pages={62–65} }

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