DOI: 10.1126/science.3975628. On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia

On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia

10.1126/science.3975628

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The cells and tissues of patients with ataxia-telangiectasia (A-T), an inherited disease characterized by a high degree of proneness to cancer, are abnormally sensitive to ionizing radiation. Noncycling cultures of normal human and A-T fibroblasts were exposed to x-rays so that the breakage and rejoining of prematurely condensed chromosomes in the G 1 phase could be compared. After a dose of 6.0 grays, both cell types had the same initial frequency of breaks and the same rate for rejoining of the breaks, but the fraction of breaks that did not rejoin was five to six times greater for the A-T cells. The results also show that progression of cells into the S phase is not a prerequisite for the increased frequency of chromosome fragments that appear in mitosis after A-T cells are irradiated in the G 1 or G 0 phase.

Bibliography

Cornforth, M. N., & Bedford, J. S. (1985). On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia. Science, 227(4694), 1589â1591.

Authors 2

Michael N. Cornforth (first)
Joel S. Bedford (additional)

References 38 Referenced 223

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:16 a.m.)
Indexed	1 month ago (July 23, 2025, 7:59 a.m.)
Issued	40 years, 4 months ago (March 29, 1985)
Published	40 years, 4 months ago (March 29, 1985)
Published Print	40 years, 4 months ago (March 29, 1985)

Funders 0

None

BibTeX

@article{Cornforth_1985, title={On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia}, volume={227}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3975628}, DOI={10.1126/science.3975628}, number={4694}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cornforth, Michael N. and Bedford, Joel S.}, year={1985}, month=mar, pages={1589–1591} }

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