DOI: 10.1126/science.3945815. Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex

Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex

10.1126/science.3945815

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

γ-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.

Bibliography

Celio, M. R. (1986). Parvalbumin in Most Î³-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex. Science, 231(4741), 995â997.

Authors 1

Marco R. Celio (first)

References 27 Referenced 635

ANAST, C.S., DISORDERS MINERAL ME: 423 (1981). / DISORDERS MINERAL ME (1981)
BERCHTOLD, M.W., PARVALBUMIN IN NON-MUSCLE TISSUES OF THE RAT - QUANTITATION AND IMMUNOHISTOCHEMICAL LOCALIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 5189 (1984). (10.1016/S0021-9258(17)42974-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1984)
BLAKE, I.O., THE INTERACTION OF GAMMA-AMINOBUTIRIC ACID WITH HYDRATED CA-2+ AND MG-2+ - A PSEUDOPOTENTIAL ABINITIO STUDY, JOURNAL OF THEORETICAL BIOLOGY 104: 571 (1983). (10.1016/0022-5193(83)90246-1) / JOURNAL OF THEORETICAL BIOLOGY (1983)
BROOKS, V.B., HDB PHYSL NERVOUS SY 2: 877 (1981). / HDB PHYSL NERVOUS SY (1981)
CARROLL, E.W., QUANTITATIVE LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS OF CYTOCHROME OXIDASE-RICH ZONES IN THE STRIATE CORTEX OF THE SQUIRREL-MONKEY, JOURNAL OF COMPARATIVE NEUROLOGY 222: 1 (1984). (10.1002/cne.902220102) / JOURNAL OF COMPARATIVE NEUROLOGY (1984)
CELIO, M.R., CALCIUM-BINDING PROTEIN PARVALBUMIN AS A NEURONAL MARKER, NATURE 293: 300 (1981). (10.1038/293300a0) / NATURE (1981)
CELIO M.R. THESIS U ZURICH (1984).
COX, J.A., CALCIUM BINDING PROT: 266 (1977). / CALCIUM BINDING PROT (1977)
DELONG, M.R., HDB PHYSL 2: 1033 (1981). / HDB PHYSL (1981)
ITO, M, CEREBELLUM NEURAL CO: 106 (1984). / CEREBELLUM NEURAL CO (1984)
KAGEYAMA, G.H., HISTOCHEMICAL-LOCALIZATION OF CYTOCHROME-OXIDASE IN THE HIPPOCAMPUS - CORRELATION WITH SPECIFIC NEURONAL TYPES AND AFFERENT PATHWAYS, NEUROSCIENCE 7: 2337 (1982). (10.1016/0306-4522(82)90199-3) / NEUROSCIENCE (1982)
KRETSINGER, R.H., NEUROSCIENCES RESEARCH PROGRAM BULLETIN 19: 275 (1981). / NEUROSCIENCES RESEARCH PROGRAM BULLETIN (1981)
MEECH, R.W., CALCIUM-DEPENDENT POTASSIUM ACTIVATION IN NERVOUS TISSUES, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 7: 1 (1978). (10.1146/annurev.bb.07.060178.000245) / ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING (1978)
OERTEL, W.H., PRODUCTION OF AN ANTISERUM TO RAT-BRAIN GLUTAMATE (GAD)-CYSTEINE SULFINATE (CSD) DECARBOXYLASE, BRAIN RESEARCH BULLETIN 5: 713 (1980). (10.1016/0361-9230(80)90117-3) / BRAIN RESEARCH BULLETIN (1980)
PERIS, J, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 2: 283 (1985). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1985)
RIBAK, C.E., EPILEPSY: 109 (1983). / EPILEPSY (1983)
RIBAK, C.E., ULTRASTRUCTURE OF THE PYRAMIDAL BASKET CELLS IN THE DENTATE GYRUS OF THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 192: 903 (1980). (10.1002/cne.901920416) / JOURNAL OF COMPARATIVE NEUROLOGY (1980)
SAITO, K, IMMUNOHISTOCHEMICAL LOCALIZATION OF GLUTAMATE DECARBOXYLASE IN RAT CEREBELLUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 269 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)
SCHLAG, J, ELECTROPHYSIOLOGICAL PROPERTIES OF UNITS OF THALAMIC RETICULAR COMPLEX, EXPERIMENTAL NEUROLOGY 32: 79 (1971). (10.1016/0014-4886(71)90167-1) / EXPERIMENTAL NEUROLOGY (1971)
SCHOCH, P, CO-LOCALIZATION OF GABAA RECEPTORS AND BENZODIAZEPINE RECEPTORS IN THE BRAIN SHOWN BY MONOCLONAL-ANTIBODIES, NATURE 314: 168 (1985). (10.1038/314168a0) / NATURE (1985)
SCHWARTZKROIN, P.A., PHYSIOLOGICAL AND MORPHOLOGICAL IDENTIFICATION OF A NON-PYRAMIDAL HIPPOCAMPAL CELL TYPE, BRAIN RESEARCH 157: 1 (1978). (10.1016/0006-8993(78)90991-5) / BRAIN RESEARCH (1978)
Seguela, P., Proceedings of the National Academy of Sciences of the United States of America 81: 3888 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
SIMONS, D.J., RESPONSE PROPERTIES OF VIBRISSA UNITS IN RAT SI SOMATOSENSORY NEOCORTEX, JOURNAL OF NEUROPHYSIOLOGY 41: 798 (1978). (10.1152/jn.1978.41.3.798) / JOURNAL OF NEUROPHYSIOLOGY (1978)
SOMOGYI, P, ANTISERA TO GAMMA-AMINOBUTYRIC ACID .2. IMMUNOCYTOCHEMICAL APPLICATION TO THE CENTRAL NERVOUS-SYSTEM, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 33: 240 (1985). (10.1177/33.3.2579123) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1985)
STORMMATHISEN, J, 1ST VISUALIZATION OF GLUTAMATE AND GABA IN NEURONS BY IMMUNOCYTOCHEMISTRY, NATURE 301: 517 (1983). (10.1038/301517a0) / NATURE (1983)
10.1007/BF01011956
WONGRILEY, M, EFFECT OF IMPULSE BLOCKAGE ON CYTOCHROME-OXIDASE ACTIVITY IN MONKEY VISUAL-SYSTEM, NATURE 307: 262 (1984). (10.1038/307262a0) / NATURE (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:19 a.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	39 years, 5 months ago (Feb. 28, 1986)
Published	39 years, 5 months ago (Feb. 28, 1986)
Published Print	39 years, 5 months ago (Feb. 28, 1986)

Funders 0

None

BibTeX

@article{Celio_1986, title={Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex}, volume={231}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3945815}, DOI={10.1126/science.3945815}, number={4741}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Celio, Marco R.}, year={1986}, month=feb, pages={995–997} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        7
      ]
    ],
    "date-time": "2025-07-07T06:28:29Z",
    "timestamp": 1751869709652
  },
  "reference-count": 27,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4741",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1986,
        2,
        28
      ]
    ]
  },
  "abstract": "<jats:p>\u03b3-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.</jats:p>",
  "DOI": "10.1126/science.3945815",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T20:28:52Z",
    "timestamp": 1160080132000
  },
  "page": "995-997",
  "source": "Crossref",
  "is-referenced-by-count": 635,
  "title": "Parvalbumin in Most \u03b3-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex",
  "prefix": "10.1126",
  "volume": "231",
  "author": [
    {
      "given": "Marco R.",
      "family": "Celio",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "first-page": "423",
      "year": "1981",
      "unstructured": "ANAST, C.S., DISORDERS MINERAL ME: 423 (1981).",
      "journal-title": "DISORDERS MINERAL ME"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "5189",
      "DOI": "10.1016/S0021-9258(17)42974-7",
      "volume": "259",
      "year": "1984",
      "unstructured": "BERCHTOLD, M.W., PARVALBUMIN IN NON-MUSCLE TISSUES OF THE RAT - QUANTITATION AND IMMUNOHISTOCHEMICAL LOCALIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 5189 (1984).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "first-page": "571",
      "DOI": "10.1016/0022-5193(83)90246-1",
      "volume": "104",
      "year": "1983",
      "unstructured": "BLAKE, I.O., THE INTERACTION OF GAMMA-AMINOBUTIRIC ACID WITH HYDRATED CA-2+ AND MG-2+ - A PSEUDOPOTENTIAL ABINITIO STUDY, JOURNAL OF THEORETICAL BIOLOGY 104: 571 (1983).",
      "journal-title": "JOURNAL OF THEORETICAL BIOLOGY"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "877",
      "volume": "2",
      "year": "1981",
      "unstructured": "BROOKS, V.B., HDB PHYSL NERVOUS SY 2: 877 (1981).",
      "journal-title": "HDB PHYSL NERVOUS SY"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1002/cne.902220102",
      "volume": "222",
      "year": "1984",
      "unstructured": "CARROLL, E.W., QUANTITATIVE LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS OF CYTOCHROME OXIDASE-RICH ZONES IN THE STRIATE CORTEX OF THE SQUIRREL-MONKEY, JOURNAL OF COMPARATIVE NEUROLOGY 222: 1 (1984).",
      "journal-title": "JOURNAL OF COMPARATIVE NEUROLOGY"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "300",
      "DOI": "10.1038/293300a0",
      "volume": "293",
      "year": "1981",
      "unstructured": "CELIO, M.R., CALCIUM-BINDING PROTEIN PARVALBUMIN AS A NEURONAL MARKER, NATURE 293: 300 (1981).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_7_1",
      "unstructured": "CELIO M.R. THESIS U ZURICH (1984)."
    },
    {
      "key": "e_1_2_1_8_1",
      "first-page": "266",
      "year": "1977",
      "unstructured": "COX, J.A., CALCIUM BINDING PROT: 266 (1977).",
      "journal-title": "CALCIUM BINDING PROT"
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "1033",
      "volume": "2",
      "year": "1981",
      "unstructured": "DELONG, M.R., HDB PHYSL 2: 1033 (1981).",
      "journal-title": "HDB PHYSL"
    },
    {
      "key": "e_1_2_1_10_1",
      "first-page": "106",
      "year": "1984",
      "unstructured": "ITO, M, CEREBELLUM NEURAL CO: 106 (1984).",
      "journal-title": "CEREBELLUM NEURAL CO"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "2337",
      "DOI": "10.1016/0306-4522(82)90199-3",
      "volume": "7",
      "year": "1982",
      "unstructured": "KAGEYAMA, G.H., HISTOCHEMICAL-LOCALIZATION OF CYTOCHROME-OXIDASE IN THE HIPPOCAMPUS - CORRELATION WITH SPECIFIC NEURONAL TYPES AND AFFERENT PATHWAYS, NEUROSCIENCE 7: 2337 (1982).",
      "journal-title": "NEUROSCIENCE"
    },
    {
      "key": "e_1_2_1_12_1",
      "first-page": "275",
      "volume": "19",
      "year": "1981",
      "unstructured": "KRETSINGER, R.H., NEUROSCIENCES RESEARCH PROGRAM BULLETIN 19: 275 (1981).",
      "journal-title": "NEUROSCIENCES RESEARCH PROGRAM BULLETIN"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1146/annurev.bb.07.060178.000245",
      "volume": "7",
      "year": "1978",
      "unstructured": "MEECH, R.W., CALCIUM-DEPENDENT POTASSIUM ACTIVATION IN NERVOUS TISSUES, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 7: 1 (1978).",
      "journal-title": "ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1016/0361-9230(80)90117-3",
      "volume": "5",
      "year": "1980",
      "unstructured": "OERTEL, W.H., PRODUCTION OF AN ANTISERUM TO RAT-BRAIN GLUTAMATE (GAD)-CYSTEINE SULFINATE (CSD) DECARBOXYLASE, BRAIN RESEARCH BULLETIN 5: 713 (1980).",
      "journal-title": "BRAIN RESEARCH BULLETIN"
    },
    {
      "key": "e_1_2_1_15_1",
      "first-page": "283",
      "volume": "2",
      "year": "1985",
      "unstructured": "PERIS, J, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 2: 283 (1985).",
      "journal-title": "SOCIETY FOR NEUROSCIENCE. ABSTRACTS"
    },
    {
      "key": "e_1_2_1_16_1",
      "first-page": "109",
      "year": "1983",
      "unstructured": "RIBAK, C.E., EPILEPSY: 109 (1983).",
      "journal-title": "EPILEPSY"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "903",
      "DOI": "10.1002/cne.901920416",
      "volume": "192",
      "year": "1980",
      "unstructured": "RIBAK, C.E., ULTRASTRUCTURE OF THE PYRAMIDAL BASKET CELLS IN THE DENTATE GYRUS OF THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 192: 903 (1980).",
      "journal-title": "JOURNAL OF COMPARATIVE NEUROLOGY"
    },
    {
      "key": "e_1_2_1_18_1",
      "first-page": "269",
      "volume": "71",
      "year": "1974",
      "unstructured": "SAITO, K, IMMUNOHISTOCHEMICAL LOCALIZATION OF GLUTAMATE DECARBOXYLASE IN RAT CEREBELLUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 269 (1974).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/0014-4886(71)90167-1",
      "volume": "32",
      "year": "1971",
      "unstructured": "SCHLAG, J, ELECTROPHYSIOLOGICAL PROPERTIES OF UNITS OF THALAMIC RETICULAR COMPLEX, EXPERIMENTAL NEUROLOGY 32: 79 (1971).",
      "journal-title": "EXPERIMENTAL NEUROLOGY"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "168",
      "DOI": "10.1038/314168a0",
      "volume": "314",
      "year": "1985",
      "unstructured": "SCHOCH, P, CO-LOCALIZATION OF GABAA RECEPTORS AND BENZODIAZEPINE RECEPTORS IN THE BRAIN SHOWN BY MONOCLONAL-ANTIBODIES, NATURE 314: 168 (1985).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0006-8993(78)90991-5",
      "volume": "157",
      "year": "1978",
      "unstructured": "SCHWARTZKROIN, P.A., PHYSIOLOGICAL AND MORPHOLOGICAL IDENTIFICATION OF A NON-PYRAMIDAL HIPPOCAMPAL CELL TYPE, BRAIN RESEARCH 157: 1 (1978).",
      "journal-title": "BRAIN RESEARCH"
    },
    {
      "key": "e_1_2_1_22_1",
      "first-page": "3888",
      "volume": "81",
      "year": "1984",
      "unstructured": "Seguela, P., Proceedings of the National Academy of Sciences of the United States of America 81: 3888 (1984).",
      "journal-title": "Proceedings of the National Academy of Sciences of the United States of America"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "798",
      "DOI": "10.1152/jn.1978.41.3.798",
      "volume": "41",
      "year": "1978",
      "unstructured": "SIMONS, D.J., RESPONSE PROPERTIES OF VIBRISSA UNITS IN RAT SI SOMATOSENSORY NEOCORTEX, JOURNAL OF NEUROPHYSIOLOGY 41: 798 (1978).",
      "journal-title": "JOURNAL OF NEUROPHYSIOLOGY"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1177/33.3.2579123",
      "volume": "33",
      "year": "1985",
      "unstructured": "SOMOGYI, P, ANTISERA TO GAMMA-AMINOBUTYRIC ACID .2. IMMUNOCYTOCHEMICAL APPLICATION TO THE CENTRAL NERVOUS-SYSTEM, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 33: 240 (1985).",
      "journal-title": "JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "517",
      "DOI": "10.1038/301517a0",
      "volume": "301",
      "year": "1983",
      "unstructured": "STORMMATHISEN, J, 1ST VISUALIZATION OF GLUTAMATE AND GABA IN NEURONS BY IMMUNOCYTOCHEMISTRY, NATURE 301: 517 (1983).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF01011956"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "262",
      "DOI": "10.1038/307262a0",
      "volume": "307",
      "year": "1984",
      "unstructured": "WONGRILEY, M, EFFECT OF IMPULSE BLOCKAGE ON CYTOCHROME-OXIDASE ACTIVITY IN MONKEY VISUAL-SYSTEM, NATURE 307: 262 (1984).",
      "journal-title": "NATURE"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.3945815",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        14
      ]
    ],
    "date-time": "2024-01-14T09:19:32Z",
    "timestamp": 1705223972000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.3945815"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1986,
        2,
        28
      ]
    ]
  },
  "references-count": 27,
  "journal-issue": {
    "issue": "4741",
    "published-print": {
      "date-parts": [
        [
          1986,
          2,
          28
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3945815"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3945815",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1986,
        2,
        28
      ]
    ]
  }
}