DOI: 10.1126/science.3917575. Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

10.1126/science.3917575

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heavy-chain and SV40 enhancers bind a common factor essential for enhancer function. In contrast, fibroblast cells contain a functionally distinct factor that is used by the SV40 but not by the heavy-chain enhancer. The existence of different factors in these cells may explain the previously described lymphoid cell specificity of the heavy-chain enhancer.

Bibliography

Mercola, M., Goverman, J., Mirell, C., & Calame, K. (1985). Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors. Science, 227(4684), 266â270.

Authors 4

Mark Mercola (first)
Joan Goverman (additional)
Carol Mirell (additional)
Kathryn Calame (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:28 a.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 6:05 p.m.)
Issued	40 years, 7 months ago (Jan. 18, 1985)
Published	40 years, 7 months ago (Jan. 18, 1985)
Published Print	40 years, 7 months ago (Jan. 18, 1985)

Funders 0

None

BibTeX

@article{Mercola_1985, title={Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors}, volume={227}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3917575}, DOI={10.1126/science.3917575}, number={4684}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mercola, Mark and Goverman, Joan and Mirell, Carol and Calame, Kathryn}, year={1985}, month=jan, pages={266–270} }

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