DOI: 10.1126/science.3898366. A Model for the Tertiary Structure of p21, the Product of the <i>ras</i> Oncogene

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

10.1126/science.3898366

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A model was developed for the structure of p21, the protein with a molecular weight of 21,000 that is produced by the ras genes. This model predicts that p21 consists of a central core of β-sheet structure, connected by loops and α helices. Four of these loops comprise the guanine nucleotide binding site. The phosphoryl binding region is made up of amino acid sequences from 10 to 16 and from 57 to 63 of p21. The latter sequence may contain a site for magnesium binding. Amino acids defining guanine specificity are Asn-116 and Asp-119, and sequences around amino acid 145 may contribute to guanine binding. The model makes it possible to visualize how oncogenic mutations of p21 affect interaction with guanine nucleotides.

Bibliography

McCormick, F., Clark, B. F. C., la Cour, T. F. M., Kjeldgaard, M., Norskov-Lauritsen, L., & Nyborg, J. (1985). A Model for the Tertiary Structure of p21, the Product of the ras Oncogene. Science, 230(4721), 78â82.

Authors 6

Frank McCormick (first)
Brian F. C. Clark (additional)
Troels F. M. la Cour (additional)
Morten Kjeldgaard (additional)
Leif Norskov-Lauritsen (additional)
Jens Nyborg (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:26 a.m.)
Indexed	3 weeks, 5 days ago (July 26, 2025, 5:01 a.m.)
Issued	39 years, 10 months ago (Oct. 4, 1985)
Published	39 years, 10 months ago (Oct. 4, 1985)
Published Print	39 years, 10 months ago (Oct. 4, 1985)

Funders 0

None

BibTeX

@article{McCormick_1985, title={A Model for the Tertiary Structure of p21, the Product of the ras Oncogene}, volume={230}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3898366}, DOI={10.1126/science.3898366}, number={4721}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={McCormick, Frank and Clark, Brian F. C. and la Cour, Troels F. M. and Kjeldgaard, Morten and Norskov-Lauritsen, Leif and Nyborg, Jens}, year={1985}, month=oct, pages={78–82} }

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