DOI: 10.1126/science.3895435. Chromosome-Sized DNA Molecules of <i>Plasmodium falciparum</i>

Chromosome-Sized DNA Molecules of Plasmodium falciparum

10.1126/science.3895435

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.

Bibliography

Van der Ploeg, L. H. T., Smits, M., Ponnudurai, T., Vermeulen, A., Meuwissen, J. H. E. Th., & Langsley, G. (1985). Chromosome-Sized DNA Molecules of Plasmodium falciparum. Science, 229(4714), 658â661.

Authors 6

Lex H. T. Van der Ploeg (first)
Mari Smits (additional)
Thivi Ponnudurai (additional)
Arno Vermeulen (additional)
Joep H. E. Th. Meuwissen (additional)
Gordon Langsley (additional)

References 17 Referenced 117

Beale, G. H., Rodent Malaria: 213 (1978). / Rodent Malaria (1978)
GOMAN, M, THE ESTABLISHMENT OF GENOMIC DNA LIBRARIES FOR THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM AND IDENTIFICATION OF INDIVIDUAL CLONES BY HYBRIDIZATION, MOLECULAR AND BIOCHEMICAL PARASITOLOGY 5: 391 (1982). (10.1016/0166-6851(82)90012-3) / MOLECULAR AND BIOCHEMICAL PARASITOLOGY (1982)
KOENEN, M, HUMAN ANTISERA DETECT A PLASMODIUM-FALCIPARUM GENOMIC CLONE ENCODING A NONAPEPTIDE REPEAT, NATURE 311: 382 (1984). (10.1038/311382a0) / NATURE (1984)
Langsley, G., Nucleic Acids Research 13: 4191 (1985). (10.1093/nar/13.11.4191) / Nucleic Acids Research (1985)
LANGSLEY, G, CLONING AND CHARACTERIZATION OF THE RIBOSOMAL-RNA GENES FROM THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM, NUCLEIC ACIDS RESEARCH 11: 8703 (1983). (10.1093/nar/11.24.8703) / NUCLEIC ACIDS RESEARCH (1983)
POLLACK, Y, THE GENOME OF PLASMODIUM-FALCIPARUM .1. DNA-BASE COMPOSITION, NUCLEIC ACIDS RESEARCH 10: 539 (1982). (10.1093/nar/10.2.539) / NUCLEIC ACIDS RESEARCH (1982)
PONNUDURAI T unpublished data.
10.1016/0092-8674(84)90301-5
Schwartz, D. C., Cold Spring Harbor Symposia on Quantitative Biology 47: 189 (1983). (10.1101/SQB.1983.047.01.024) / Cold Spring Harbor Symposia on Quantitative Biology (1983)
SINDEN, R.E., THE CELL BIOLOGY OF SEXUAL DEVELOPMENT IN PLASMODIUM, PARASITOLOGY 86: 7 (1983). / PARASITOLOGY (1983)
THAITHONG, S, CLONAL DIVERSITY IN A SINGLE ISOLATE OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 78: 242 (1984). (10.1016/0035-9203(84)90287-6) / TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (1984)
VANDERPLOEG, LHT, ANTIGENIC VARIATION IN TRYPANOSOMA BRUCEI ANALYZED BY ELECTROPHORETIC SEPARATION OF CHROMOSOME-SIZED DNA-MOLECULES, CELL 37: 77 (1984). (10.1016/0092-8674(84)90302-7) / CELL (1984)
VANDERPLOEG, LHT, CHROMOSOME REARRANGEMENTS IN TRYPANOSOMA BRUCEI, CELL 39: 213 (1984). (10.1016/0092-8674(84)90207-1) / CELL (1984)
VANDERPLOEG, LHT, CHROMOSOMES OF KINETOPLASTIDA, EMBO JOURNAL 3: 3109 (1984). (10.1002/j.1460-2075.1984.tb02266.x) / EMBO JOURNAL (1984)
Van der Ploeg, L. H. T., Philosophical Transactions of the Royal Society B 307: 13 (1984). / Philosophical Transactions of the Royal Society B (1984)
VANDERPLOEG LHT unpublished data.
VERMEULEN, A.N., THE PURIFICATION OF PLASMODIUM-FALCIPARUM MACROGAMETES AND OR ZYGOTES PREPARED FROM INVITRO CULTURES, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 77: 753 (1983). (10.1016/0035-9203(83)90280-8) / TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (1983)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:15 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 6:10 a.m.)
Issued	40 years ago (Aug. 16, 1985)
Published	40 years ago (Aug. 16, 1985)
Published Print	40 years ago (Aug. 16, 1985)

Funders 0

None

BibTeX

@article{Van_der_Ploeg_1985, title={Chromosome-Sized DNA Molecules of Plasmodium falciparum}, volume={229}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3895435}, DOI={10.1126/science.3895435}, number={4714}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Van der Ploeg, Lex H. T. and Smits, Mari and Ponnudurai, Thivi and Vermeulen, Arno and Meuwissen, Joep H. E. Th. and Langsley, Gordon}, year={1985}, month=aug, pages={658–661} }

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