DOI: 10.1126/science.3873110. Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia

Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia

10.1126/science.3873110

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Consistent chromosomal translocations in neoplastic cells may alter the expression of proto-oncogenes that are located near the breakpoints. The complementary DNA sequence of the human insulin receptor is similar to those of the EGF receptor ( erbB oncogene) and products of the src family of oncogenes. With in situ hybridization and Southern blot analysis of somatic cell hybrid DNA, the human insulin receptor gene was mapped to the distal short arm of chromosome 19 (bands p13.2→p13.3), a site involved in a nonrandom translocation in pre-B-cell acute leukemia.

Bibliography

Yang-Feng, T. L., Francke, U., & Ullrich, A. (1985). Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia. Science, 228(4700), 728â731.

Authors 3

Teresa L. Yang-Feng (first)
Uta Francke (additional)
Axel Ullrich (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:19 a.m.)
Indexed	4 months, 4 weeks ago (April 5, 2025, 10:03 a.m.)
Issued	40 years, 3 months ago (May 10, 1985)
Published	40 years, 3 months ago (May 10, 1985)
Published Print	40 years, 3 months ago (May 10, 1985)

Funders 0

None

BibTeX

@article{Yang_Feng_1985, title={Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia}, volume={228}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3873110}, DOI={10.1126/science.3873110}, number={4700}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yang-Feng, Teresa L. and Francke, Uta and Ullrich, Axel}, year={1985}, month=may, pages={728–731} }

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