DOI: 10.1126/science.3871253. Partial Primary Structure of the Alpha and Beta Chains of Human Tumor T-Cell Receptors

Partial Primary Structure of the Alpha and Beta Chains of Human Tumor T-Cell Receptors

10.1126/science.3871253

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The T-cell receptor for antigen (Ti) was purified from the human tumor cell line HPB-ALL. Amino-terminal sequence analysis of an acid-cleaved peptide of the Tiα chain showed that it is highly homologous to a putative murine α chain recently described. Amino-terminal sequence analysis of the Tiβ chain revealed that it shares 50 percent homology with the Tiβ chain amino acid sequences from two other human T-cell tumors. Nucleotide sequence analysis of a complementary DNA clone encoding the Tiβ chain from the HPB-MLT cell line showed that this chain represents a second human constant region gene segment and suggested that it arises from direct joining of the variable and joining gene segments without any intervening D region sequences.

Authors 10

Nancy Jones (first)
Jeffrey Leiden (additional)
Deno Dialynas (additional)
John Fraser (additional)
Martha Clabby (additional)
Takashi Kishimoto (additional)
Jack L. Strominger (additional)
Dana Andrews (additional)
William Lane (additional)
James Woody (additional)

References 22 Referenced 33

Acuto, O., Proceedings of the National Academy of Sciences of the United States of America 81: 3851 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
ALLISON, J.P., TUMOR-SPECIFIC ANTIGEN OF MURINE T-LYMPHOMA DEFINED WITH MONOCLONAL-ANTIBODY, JOURNAL OF IMMUNOLOGY 129: 2293 (1982). (10.4049/jimmunol.129.5.2293) / JOURNAL OF IMMUNOLOGY (1982)
10.1038/309322a0
CHIEN, Y, A 3RD-TYPE OF MURINE T-CELL RECEPTOR GENE, NATURE 312: 31 (1984). (10.1038/312031a0) / NATURE (1984)
Early, P., Cell 19: 981 (1980). (10.1016/0092-8674(80)90089-6) / Cell (1980)
10.1038/310387a0
HANNUM, C.H., IMMUNOGLOBULIN-LIKE NATURE OF THE ALPHA-CHAIN OF A HUMAN T-CELL ANTIGEN MHC RECEPTOR, NATURE 312: 65 (1984). (10.1038/312065a0) / NATURE (1984)
10.1038/308149a0
HEDRICK, S.M., SEQUENCE RELATIONSHIPS BETWEEN PUTATIVE T-CELL RECEPTOR POLYPEPTIDES AND IMMUNOGLOBULINS, NATURE 308: 153 (1984). (10.1038/308153a0) / NATURE (1984)
HUNKAPILLER, M.W., ISOLATION OF MICROGRAM QUANTITIES OF PROTEINS FROM POLYACRYLAMIDE GELS FOR AMINO-ACID SEQUENCE-ANALYSIS, METHODS IN ENZYMOLOGY 91: 227 (1983). (10.1016/S0076-6879(83)91019-4) / METHODS IN ENZYMOLOGY (1983)
KAPPLER, J, THE MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTED ANTIGEN RECEPTOR ON T-CELLS .3. THE MOUSE T-CELL RECEPTOR - COMPARISON OF MHC-RESTRICTED RECEPTORS ON 2 T-CELL HYBRIDOMAS, CELL 34: 727 (1983). (10.1016/0092-8674(83)90529-9) / CELL (1983)
KAPPLER, J, THE MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED ANTIGEN RECEPTOR ON T-CELLS IN MOUSE AND MAN .5. IDENTIFICATION OF CONSTANT AND VARIABLE PEPTIDES, CELL 35: 295 (1983). (10.1016/0092-8674(83)90232-5) / CELL (1983)
10.1016/0092-8674(84)90444-6
MEUER, S.C., CLONOTYPIC STRUCTURES INVOLVED IN ANTIGEN-SPECIFIC HUMAN T-CELL FUNCTION - RELATIONSHIP TO THE T3-MOLECULAR COMPLEX, JOURNAL OF EXPERIMENTAL MEDICINE 157: 705 (1983). (10.1084/jem.157.2.705) / JOURNAL OF EXPERIMENTAL MEDICINE (1983)
MORRISSEY, J.H., SILVER STAIN FOR PROTEINS IN POLYACRYLAMIDE GELS - A MODIFIED PROCEDURE WITH ENHANCED UNIFORM SENSITIVITY, ANALYTICAL BIOCHEMISTRY 117: 307 (1981). (10.1016/0003-2697(81)90783-1) / ANALYTICAL BIOCHEMISTRY (1981)
SAITO, H, COMPLETE PRIMARY STRUCTURE OF A HETERODIMERIC T-CELL RECEPTOR DEDUCED FROM CDNA SEQUENCES, NATURE 309: 757 (1984). (10.1038/309757a0) / NATURE (1984)
SAITO, H, A 3RD REARRANGED AND EXPRESSED GENE IN A CLONE OF CYTO-TOXIC LYMPHOCYTES-T, NATURE 312: 36 (1984). (10.1038/312036a0) / NATURE (1984)
10.1073/pnas.74.12.5463
10.1038/311344a0
TERHORST, C, FURTHER STRUCTURAL STUDIES OF HEAVY-CHAIN OF HLA ANTIGENS AND ITS SIMILARITY TO IMMUNOGLOBULINS - (HISTOCOMPATIBILITY ANTIGENS GLYCOPROTEINS AMINO ACID SEQUENCES), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 4002 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
10.1038/302575a0
YANAGI, Y, A HUMAN T-CELL-SPECIFIC CDNA CLONE ENCODES A PROTEIN HAVING EXTENSIVE HOMOLOGY TO IMMUNOGLOBULIN-CHAINS, NATURE 308: 145 (1984). (10.1038/308145a0) / NATURE (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:28 a.m.)
Indexed	1 year, 7 months ago (Jan. 14, 2024, 7:03 p.m.)
Issued	40 years, 7 months ago (Jan. 18, 1985)
Published	40 years, 7 months ago (Jan. 18, 1985)
Published Print	40 years, 7 months ago (Jan. 18, 1985)

Funders 0

None

BibTeX

@article{Jones_1985, title={Partial Primary Structure of the Alpha and Beta Chains of Human Tumor T-Cell Receptors}, volume={227}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3871253}, DOI={10.1126/science.3871253}, number={4684}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Jones, Nancy and Leiden, Jeffrey and Dialynas, Deno and Fraser, John and Clabby, Martha and Kishimoto, Takashi and Strominger, Jack L. and Andrews, Dana and Lane, William and Woody, James}, year={1985}, month=jan, pages={311–314} }

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