DOI: 10.1126/science.386514. Rapid Killing of Single Neurons by Irradiation of Intracellularly Injected Dye

Rapid Killing of Single Neurons by Irradiation of Intracellularly Injected Dye

10.1126/science.386514

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A simple technique for rapidly killing all or part of single neurons consists of filling the cell with Lucifer Yellow CH and irradiating all or part of it with intense blue light. Such treatment kills the irradiated part of the cell within a few minutes. Adjacent cells are not affected.

Bibliography

Miller, J. P., & Selverston, A. I. (1979). Rapid Killing of Single Neurons by Irradiation of Intracellularly Injected Dye. Science, 206(4419), 702â704.

Authors 2

John P. Miller (first)
Allen I. Selverston (additional)

References 10 Referenced 277

AMY, R.L., RUBY LASER MICRO-IRRADIATION OF SINGLE TISSUE CULTURE CELLS VITALLY STAINED WITH JANUS GREEN B .I. EFFECTS OBSERVED WITH PHASE-CONTRAST MICROSCOPE, EXPERIMENTAL CELL RESEARCH 45: 361 (1967). (10.1016/0014-4827(67)90186-3) / EXPERIMENTAL CELL RESEARCH (1967)
BOWLING, D, DESTRUCTION OF A SINGLE CELL IN CENTRAL NERVOUS-SYSTEM OF LEECH AS A MEANS OF ANALYZING ITS CONNECTIONS AND FUNCTIONAL ROLE, JOURNAL OF PHYSIOLOGY-LONDON 282: 169 (1978). (10.1113/jphysiol.1978.sp012455) / JOURNAL OF PHYSIOLOGY-LONDON (1978)
CLEMENT, A.C., DEVELOPMENT OF ILYANASSA FOLLOWING REMOVAL OF D MACROMERE AT SUCCESSIVE CLEAVAGE STAGES, JOURNAL OF EXPERIMENTAL ZOOLOGY 149: 193 (1962). (10.1002/jez.1401490304) / JOURNAL OF EXPERIMENTAL ZOOLOGY (1962)
FURSHPAN, E.J., TRANSMISSION AT THE GIANT MOTOR SYNAPSES OF THE CRAYFISH, JOURNAL OF PHYSIOLOGY-LONDON 145: 289 (1959). (10.1113/jphysiol.1959.sp006143) / JOURNAL OF PHYSIOLOGY-LONDON (1959)
MACAGNO, E.R., CELL TISSUE INTERACT: 293 (1977). / CELL TISSUE INTERACT (1977)
MAYNARD, D.M., ORGANIZATION OF STOMATOGASTRIC GANGLION OF SPINY LOBSTER .4. PYLORIC SYSTEM, JOURNAL OF COMPARATIVE PHYSIOLOGY 100: 161 (1975). (10.1007/BF00613967) / JOURNAL OF COMPARATIVE PHYSIOLOGY (1975)
MORENO, G, INTERNATIONAL REVIEW OF EXPERIMENTAL PATHOLOGY 7: 99 (1969). / INTERNATIONAL REVIEW OF EXPERIMENTAL PATHOLOGY (1969)
MULLONEY, B, ORGANIZATION OF STOMATOGASTRIC GANGLION OF SPINY LOBSTER .1. NEURONS DRIVING LATERAL TEETH, JOURNAL OF COMPARATIVE PHYSIOLOGY 91: 1 (1974). (10.1007/BF00696154) / JOURNAL OF COMPARATIVE PHYSIOLOGY (1974)
PARNAS, I, KILLING OF SINGLE NEURONS BY INTRACELLULAR INJECTION OF PROTEOLYTIC-ENZYMES, NATURE 270: 626 (1977). (10.1038/270626a0) / NATURE (1977)
STEWART, W.W., FUNCTIONAL CONNECTIONS BETWEEN CELLS AS REVEALED BY DYE-COUPLING WITH A HIGHLY FLUORESCENT NAPHTHALIMIDE TRACER, CELL 14: 741 (1978). (10.1016/0092-8674(78)90256-8) / CELL (1978)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:48 a.m.)
Indexed	2 months, 3 weeks ago (June 12, 2025, 5:44 a.m.)
Issued	45 years, 9 months ago (Nov. 9, 1979)
Published	45 years, 9 months ago (Nov. 9, 1979)
Published Print	45 years, 9 months ago (Nov. 9, 1979)

Funders 0

None

BibTeX

@article{Miller_1979, title={Rapid Killing of Single Neurons by Irradiation of Intracellularly Injected Dye}, volume={206}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.386514}, DOI={10.1126/science.386514}, number={4419}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Miller, John P. and Selverston, Allen I.}, year={1979}, month=nov, pages={702–704} }

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