DOI: 10.1126/science.3854. Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

10.1126/science.3854

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

Bibliography

Creese, I., Burt, D. R., & Snyder, S. H. (1976). Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs. Science, 192(4238), 481â483.

Authors 3

Ian Creese (first)
David R. Burt (additional)
Solomon H. Snyder (additional)

References 38 Referenced 1,779

AYD, F.J., INT DRUG THER NEWSLE 7: 13 (1972). / INT DRUG THER NEWSLE (1972)
AYD, F.J., INT DRUG THER NEWSLE 10: 25 (1975). / INT DRUG THER NEWSLE (1975)
AYD, F.J., INT DRUG THER NEWSL 6: 17 (1971). / INT DRUG THER NEWSL (1971)
AYD, F.J., INT DRUG THERAPY NEW 6: 25 (1971). / INT DRUG THERAPY NEW (1971)
BURT, D.R., NEUROSCIENCE ABSTRACTS 1: 404 (1975). / NEUROSCIENCE ABSTRACTS (1975)
BURT, D.R., DOPAMINE RECEPTOR-BINDING IN CORPUS STRIATUM OF MAMMALIAN BRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 4655 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
BYCK, R, PHARMACOL BASIS THER: 152 (1975). / PHARMACOL BASIS THER (1975)
CHANGEUX, J.P., ON EXCITABILITY AND COOPERATIVITY OF ELECTROPLAX MEMBRANE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 59: 944 (1968). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1968)
CLEMENTCORMIER, Y.C., DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN MAMMALIAN BRAIN - POSSIBLE SITE OF ACTION OF ANTIPSYCHOTIC-DRUGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 1113 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)
CREESE, I, DOPAMINE RECEPTOR-BINDING - DIFFERENTIATION OF AGONIST AND ANTAGONIST STATES WITH H-3-DOPAMINE AND HALOPERIDOL-H-3, LIFE SCIENCES 17: 993 (1975). (10.1016/0024-3205(75)90454-3) / LIFE SCIENCES (1975)
CREESE, I, DOPAMINE RECEPTOR - DIFFERENTIAL BINDING OF D-LSD AND RELATED AGENTS TO AGONIST AND ANTAGONIST STATES, LIFE SCIENCES 17: 1715 (1975). (10.1016/0024-3205(75)90118-6) / LIFE SCIENCES (1975)
CUATRECASAS, P, MEMBRANE RECEPTORS, ANNUAL REVIEW OF BIOCHEMISTRY 43: 169 (1974). (10.1146/annurev.bi.43.070174.001125) / ANNUAL REVIEW OF BIOCHEMISTRY (1974)
FEINBERG, A.P., PHENOTHIAZINE DRUGS - STRUCTURE-ACTIVITY-RELATIONSHIPS EXPLAINED BY A CONFORMATION THAT MIMICS DOPAMINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 1899 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
HORN, A.S., CHLORPROMAZINE AND DOPAMINE - CONFORMATIONAL SIMILARITIES THAT CORRELATE WITH ANTISCHIZOPHRENIC ACTIVITY OF PHENOTHIAZINE DRUGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 2325 (1971). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1971)
IVERSEN, L.L., PRE POSTSYNAPTIC REC: 207 (1975). / PRE POSTSYNAPTIC REC (1975)
JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS ( MAJOR TRANQUILLIZERS ) FROM ANIMAL DATA .I. NEUROLEPTIC ACTIVITY SPECTRA FOR RATS, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 15: 104 (1965). / ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (1965)
JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLOPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 17: 841 (1967). / ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (1967)
JANSSEN, PAJ, PIMOZIDE A CHEMICALLY NOVEL HIGHLY POTENT AND ORALLY LONG-ACTING NEUROLEPTIC DRUG .I. COMPARATIVE PHARMACOLOGY OF PIMOZIDE HALOPERIDOL AND CHLORPROMAZINE, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 18: 261 (1968). / ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (1968)
JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 16: 339 (1966). / ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (1966)
JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA .2. NEUROLEPTIC ACTIVITY SPECTRA FOR DOGS, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 15: 1196 (1965). / ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (1965)
KARLIN, A, ON APPLICATION OF A PLAUSIBLE MODEL OF ALLOSTERIC PROTEINS TO RECEPTOR FOR ACETYLCHOLINE, JOURNAL OF THEORETICAL BIOLOGY 16: 306 (1967). (10.1016/0022-5193(67)90011-2) / JOURNAL OF THEORETICAL BIOLOGY (1967)
KAROBATH, M, ANTIPSYCHOTIC-DRUGS AND DOPAMINE-STIMULATED ADENYLATE CYCLASE PREPARED FROM CORPUS STRIATUM OF RAT-BRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 2915 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)
KEBABIAN, J.W., DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN CAUDATE-NUCLEUS OF RAT-BRAIN, AND ITS SIMILARITY TO DOPAMINE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 2145 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
KETY, S.S., NEUROSCIENCES RESEARCH PROGRAM BULLETIN 10: 370 (1972). / NEUROSCIENCES RESEARCH PROGRAM BULLETIN (1972)
KOCH, MHJ, CONFORMATION OF NEUROLEPTIC DRUGS, MOLECULAR PHARMACOLOGY 10: 425 (1974). / MOLECULAR PHARMACOLOGY (1974)
KRUEGER, B.K., PRE POSTSYNAPTIC REC: 123 (1975). / PRE POSTSYNAPTIC REC (1975)
MIELKE, D.H., BUTACLAMOL HYDROCHLORIDE (AY-23,028) - EARLY EVALUATION IN SEVERELY ILL SCHIZOPHRENICS, DISEASES OF THE NERVOUS SYSTEM 36: 7 (1975). / DISEASES OF THE NERVOUS SYSTEM (1975)
MILLER, R.J., ACTION OF NEUROLEPTIC DRUGS ON DOPAMINE-STIMULATED ADENOSINE CYCLIC 3', 5'-MONOPHOSPHATE PRODUCTION IN RAT NEOSTRIATUM AND LIMBIC FOREBRAIN, MOLECULAR PHARMACOLOGY 10: 759 (1974). / MOLECULAR PHARMACOLOGY (1974)
NEIMEGEERS, CJE, DRUG RES 24: 45 (1972). / DRUG RES (1972)
SEEMAN, P, NEUROSCIENCE ABSTRACTS 1: 405 (1975). / NEUROSCIENCE ABSTRACTS (1975)
SEEMAN, P, BRAIN RECEPTORS FOR ANTIPSYCHOTIC-DRUGS AND DOPAMINE - DIRECT BINDING ASSAYS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 4376 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
10.1126/science.1145194
SNYDER, S, NEUROTRANSMITTER AND DRUG RECEPTORS IN BRAIN, BIOCHEMICAL PHARMACOLOGY 24: 1371 (1975). (10.1016/0006-2952(75)90358-5) / BIOCHEMICAL PHARMACOLOGY (1975)
Snyder S. H. Neuro. Res. Symp. Summ. in press.
10.1126/science.184.4143.1243
USDIN E PSYCHOTROPIC DRUGS R (1972).
VOITH, K, BEHAVIORAL PHARMACOLOGY OF BUTACLAMOL HYDROCHLORIDE (AY-23,028), A NEW POTENT NEUROLEPTIC DRUG, PSYCHOPHARMACOLOGIA 42: 11 (1975). (10.1007/BF00428819) / PSYCHOPHARMACOLOGIA (1975)
VONHUNGEN, K, INTERACTIONS BETWEEN LYSERGIC-ACID DIETHYLAMIDE AND DOPAMINE-SENSITIVE ADENYLATE CYCLASE SYSTEMS IN RAT-BRAIN, BRAIN RESEARCH 94: 57 (1975). (10.1016/0006-8993(75)90876-8) / BRAIN RESEARCH (1975)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:51 a.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:27 a.m.)
Indexed	1 day, 22 hours ago (Aug. 28, 2025, 8:49 a.m.)
Issued	49 years, 4 months ago (April 30, 1976)
Published	49 years, 4 months ago (April 30, 1976)
Published Print	49 years, 4 months ago (April 30, 1976)

Funders 0

None

BibTeX

@article{Creese_1976, title={Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs}, volume={192}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3854}, DOI={10.1126/science.3854}, number={4238}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Creese, Ian and Burt, David R. and Snyder, Solomon H.}, year={1976}, month=apr, pages={481–483} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        28
      ]
    ],
    "date-time": "2025-08-28T12:49:38Z",
    "timestamp": 1756385378000
  },
  "reference-count": 38,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4238",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1976,
        4,
        30
      ]
    ]
  },
  "abstract": "<jats:p>Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.</jats:p>",
  "DOI": "10.1126/science.3854",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T15:51:28Z",
    "timestamp": 1160063488000
  },
  "page": "481-483",
  "source": "Crossref",
  "is-referenced-by-count": 1779,
  "title": "Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs",
  "prefix": "10.1126",
  "volume": "192",
  "author": [
    {
      "given": "Ian",
      "family": "Creese",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"
        }
      ]
    },
    {
      "given": "David R.",
      "family": "Burt",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"
        }
      ]
    },
    {
      "given": "Solomon H.",
      "family": "Snyder",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "first-page": "13",
      "volume": "7",
      "year": "1972",
      "unstructured": "AYD, F.J., INT DRUG THER NEWSLE 7: 13 (1972).",
      "journal-title": "INT DRUG THER NEWSLE"
    },
    {
      "key": "e_1_2_1_2_1",
      "first-page": "25",
      "volume": "10",
      "year": "1975",
      "unstructured": "AYD, F.J., INT DRUG THER NEWSLE 10: 25 (1975).",
      "journal-title": "INT DRUG THER NEWSLE"
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "17",
      "volume": "6",
      "year": "1971",
      "unstructured": "AYD, F.J., INT DRUG THER NEWSL 6: 17 (1971).",
      "journal-title": "INT DRUG THER NEWSL"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "25",
      "volume": "6",
      "year": "1971",
      "unstructured": "AYD, F.J., INT DRUG THERAPY NEW 6: 25 (1971).",
      "journal-title": "INT DRUG THERAPY NEW"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "404",
      "volume": "1",
      "year": "1975",
      "unstructured": "BURT, D.R., NEUROSCIENCE ABSTRACTS 1: 404 (1975).",
      "journal-title": "NEUROSCIENCE ABSTRACTS"
    },
    {
      "key": "e_1_2_1_6_1",
      "first-page": "4655",
      "volume": "72",
      "year": "1975",
      "unstructured": "BURT, D.R., DOPAMINE RECEPTOR-BINDING IN CORPUS STRIATUM OF MAMMALIAN BRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 4655 (1975).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_7_1",
      "first-page": "152",
      "year": "1975",
      "unstructured": "BYCK, R, PHARMACOL BASIS THER: 152 (1975).",
      "journal-title": "PHARMACOL BASIS THER"
    },
    {
      "key": "e_1_2_1_8_1",
      "first-page": "944",
      "volume": "59",
      "year": "1968",
      "unstructured": "CHANGEUX, J.P., ON EXCITABILITY AND COOPERATIVITY OF ELECTROPLAX MEMBRANE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 59: 944 (1968).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "1113",
      "volume": "71",
      "year": "1974",
      "unstructured": "CLEMENTCORMIER, Y.C., DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN MAMMALIAN BRAIN - POSSIBLE SITE OF ACTION OF ANTIPSYCHOTIC-DRUGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 1113 (1974).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "993",
      "DOI": "10.1016/0024-3205(75)90454-3",
      "volume": "17",
      "year": "1975",
      "unstructured": "CREESE, I, DOPAMINE RECEPTOR-BINDING - DIFFERENTIATION OF AGONIST AND ANTAGONIST STATES WITH H-3-DOPAMINE AND HALOPERIDOL-H-3, LIFE SCIENCES 17: 993 (1975).",
      "journal-title": "LIFE SCIENCES"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "1715",
      "DOI": "10.1016/0024-3205(75)90118-6",
      "volume": "17",
      "year": "1975",
      "unstructured": "CREESE, I, DOPAMINE RECEPTOR - DIFFERENTIAL BINDING OF D-LSD AND RELATED AGENTS TO AGONIST AND ANTAGONIST STATES, LIFE SCIENCES 17: 1715 (1975).",
      "journal-title": "LIFE SCIENCES"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1146/annurev.bi.43.070174.001125",
      "volume": "43",
      "year": "1974",
      "unstructured": "CUATRECASAS, P, MEMBRANE RECEPTORS, ANNUAL REVIEW OF BIOCHEMISTRY 43: 169 (1974).",
      "journal-title": "ANNUAL REVIEW OF BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_13_1",
      "first-page": "1899",
      "volume": "72",
      "year": "1975",
      "unstructured": "FEINBERG, A.P., PHENOTHIAZINE DRUGS - STRUCTURE-ACTIVITY-RELATIONSHIPS EXPLAINED BY A CONFORMATION THAT MIMICS DOPAMINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 1899 (1975).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_14_1",
      "first-page": "2325",
      "volume": "68",
      "year": "1971",
      "unstructured": "HORN, A.S., CHLORPROMAZINE AND DOPAMINE - CONFORMATIONAL SIMILARITIES THAT CORRELATE WITH ANTISCHIZOPHRENIC ACTIVITY OF PHENOTHIAZINE DRUGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 2325 (1971).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_15_1",
      "first-page": "207",
      "year": "1975",
      "unstructured": "IVERSEN, L.L., PRE POSTSYNAPTIC REC: 207 (1975).",
      "journal-title": "PRE POSTSYNAPTIC REC"
    },
    {
      "key": "e_1_2_1_16_1",
      "first-page": "104",
      "volume": "15",
      "year": "1965",
      "unstructured": "JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS ( MAJOR TRANQUILLIZERS ) FROM ANIMAL DATA .I. NEUROLEPTIC ACTIVITY SPECTRA FOR RATS, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 15: 104 (1965).",
      "journal-title": "ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH"
    },
    {
      "key": "e_1_2_1_17_1",
      "first-page": "841",
      "volume": "17",
      "year": "1967",
      "unstructured": "JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLOPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 17: 841 (1967).",
      "journal-title": "ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH"
    },
    {
      "key": "e_1_2_1_18_1",
      "first-page": "261",
      "volume": "18",
      "year": "1968",
      "unstructured": "JANSSEN, PAJ, PIMOZIDE A CHEMICALLY NOVEL HIGHLY POTENT AND ORALLY LONG-ACTING NEUROLEPTIC DRUG .I. COMPARATIVE PHARMACOLOGY OF PIMOZIDE HALOPERIDOL AND CHLORPROMAZINE, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 18: 261 (1968).",
      "journal-title": "ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH"
    },
    {
      "key": "e_1_2_1_19_1",
      "first-page": "339",
      "volume": "16",
      "year": "1966",
      "unstructured": "JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 16: 339 (1966).",
      "journal-title": "ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH"
    },
    {
      "key": "e_1_2_1_20_1",
      "first-page": "1196",
      "volume": "15",
      "year": "1965",
      "unstructured": "JANSSEN, PAJ, IS IT POSSIBLE TO PREDICT CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA .2. NEUROLEPTIC ACTIVITY SPECTRA FOR DOGS, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 15: 1196 (1965).",
      "journal-title": "ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.1016/0022-5193(67)90011-2",
      "volume": "16",
      "year": "1967",
      "unstructured": "KARLIN, A, ON APPLICATION OF A PLAUSIBLE MODEL OF ALLOSTERIC PROTEINS TO RECEPTOR FOR ACETYLCHOLINE, JOURNAL OF THEORETICAL BIOLOGY 16: 306 (1967).",
      "journal-title": "JOURNAL OF THEORETICAL BIOLOGY"
    },
    {
      "key": "e_1_2_1_22_1",
      "first-page": "2915",
      "volume": "71",
      "year": "1974",
      "unstructured": "KAROBATH, M, ANTIPSYCHOTIC-DRUGS AND DOPAMINE-STIMULATED ADENYLATE CYCLASE PREPARED FROM CORPUS STRIATUM OF RAT-BRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 2915 (1974).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_23_1",
      "first-page": "2145",
      "volume": "69",
      "year": "1972",
      "unstructured": "KEBABIAN, J.W., DOPAMINE-SENSITIVE ADENYLATE CYCLASE IN CAUDATE-NUCLEUS OF RAT-BRAIN, AND ITS SIMILARITY TO DOPAMINE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 2145 (1972).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_24_1",
      "first-page": "370",
      "volume": "10",
      "year": "1972",
      "unstructured": "KETY, S.S., NEUROSCIENCES RESEARCH PROGRAM BULLETIN 10: 370 (1972).",
      "journal-title": "NEUROSCIENCES RESEARCH PROGRAM BULLETIN"
    },
    {
      "key": "e_1_2_1_25_1",
      "first-page": "425",
      "volume": "10",
      "year": "1974",
      "unstructured": "KOCH, MHJ, CONFORMATION OF NEUROLEPTIC DRUGS, MOLECULAR PHARMACOLOGY 10: 425 (1974).",
      "journal-title": "MOLECULAR PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "123",
      "year": "1975",
      "unstructured": "KRUEGER, B.K., PRE POSTSYNAPTIC REC: 123 (1975).",
      "journal-title": "PRE POSTSYNAPTIC REC"
    },
    {
      "key": "e_1_2_1_27_1",
      "first-page": "7",
      "volume": "36",
      "year": "1975",
      "unstructured": "MIELKE, D.H., BUTACLAMOL HYDROCHLORIDE (AY-23,028) - EARLY EVALUATION IN SEVERELY ILL SCHIZOPHRENICS, DISEASES OF THE NERVOUS SYSTEM 36: 7 (1975).",
      "journal-title": "DISEASES OF THE NERVOUS SYSTEM"
    },
    {
      "key": "e_1_2_1_28_1",
      "first-page": "759",
      "volume": "10",
      "year": "1974",
      "unstructured": "MILLER, R.J., ACTION OF NEUROLEPTIC DRUGS ON DOPAMINE-STIMULATED ADENOSINE CYCLIC 3', 5'-MONOPHOSPHATE PRODUCTION IN RAT NEOSTRIATUM AND LIMBIC FOREBRAIN, MOLECULAR PHARMACOLOGY 10: 759 (1974).",
      "journal-title": "MOLECULAR PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_29_1",
      "first-page": "45",
      "volume": "24",
      "year": "1972",
      "unstructured": "NEIMEGEERS, CJE, DRUG RES 24: 45 (1972).",
      "journal-title": "DRUG RES"
    },
    {
      "key": "e_1_2_1_30_1",
      "first-page": "405",
      "volume": "1",
      "year": "1975",
      "unstructured": "SEEMAN, P, NEUROSCIENCE ABSTRACTS 1: 405 (1975).",
      "journal-title": "NEUROSCIENCE ABSTRACTS"
    },
    {
      "key": "e_1_2_1_31_1",
      "first-page": "4376",
      "volume": "72",
      "year": "1975",
      "unstructured": "SEEMAN, P, BRAIN RECEPTORS FOR ANTIPSYCHOTIC-DRUGS AND DOPAMINE - DIRECT BINDING ASSAYS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 4376 (1975).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1145194"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "crossref",
      "first-page": "1371",
      "DOI": "10.1016/0006-2952(75)90358-5",
      "volume": "24",
      "year": "1975",
      "unstructured": "SNYDER, S, NEUROTRANSMITTER AND DRUG RECEPTORS IN BRAIN, BIOCHEMICAL PHARMACOLOGY 24: 1371 (1975).",
      "journal-title": "BIOCHEMICAL PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_34_1",
      "unstructured": "Snyder S. H. Neuro. Res. Symp. Summ. in press."
    },
    {
      "key": "e_1_2_1_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.184.4143.1243"
    },
    {
      "key": "e_1_2_1_36_1",
      "unstructured": "USDIN E PSYCHOTROPIC DRUGS R (1972)."
    },
    {
      "key": "e_1_2_1_37_1",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1007/BF00428819",
      "volume": "42",
      "year": "1975",
      "unstructured": "VOITH, K, BEHAVIORAL PHARMACOLOGY OF BUTACLAMOL HYDROCHLORIDE (AY-23,028), A NEW POTENT NEUROLEPTIC DRUG, PSYCHOPHARMACOLOGIA 42: 11 (1975).",
      "journal-title": "PSYCHOPHARMACOLOGIA"
    },
    {
      "key": "e_1_2_1_38_1",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/0006-8993(75)90876-8",
      "volume": "94",
      "year": "1975",
      "unstructured": "VONHUNGEN, K, INTERACTIONS BETWEEN LYSERGIC-ACID DIETHYLAMIDE AND DOPAMINE-SENSITIVE ADENYLATE CYCLASE SYSTEMS IN RAT-BRAIN, BRAIN RESEARCH 94: 57 (1975).",
      "journal-title": "BRAIN RESEARCH"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.3854",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        14
      ]
    ],
    "date-time": "2024-01-14T09:27:56Z",
    "timestamp": 1705224476000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.3854"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1976,
        4,
        30
      ]
    ]
  },
  "references-count": 38,
  "journal-issue": {
    "issue": "4238",
    "published-print": {
      "date-parts": [
        [
          1976,
          4,
          30
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3854"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3854",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1976,
        4,
        30
      ]
    ]
  }
}