DOI: 10.1126/science.3840606. Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

10.1126/science.3840606

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Several inherited disorders in humans and in rodents result in myelin dysgenesis and a deficiency of the molecular constituents of myelin. A complementary DNA to one of the two major myelin proteins, myelin proteolipid protein (also known as lipophilin), has been used with Southern blot analysis of somatic cell hybrid DNA to map the human proteolipid protein gene to the middle of the long arm of the human X chromosome (bands Xq13-Xq22) and to assign the murine proteolipid protein gene to the mouse X chromosome. Comparison of the gene maps of the human and mouse X chromosomes suggests that myelin proteolipid protein may be involved in X-linked mutations at the mouse jimpy locus and has implications for Pelizaeus-Merzbacher disease, a human inherited X-linked myelin disorder.

Bibliography

Willard, H. F., & Riordan, J. R. (1985). Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders. Science, 230(4728), 940â942.

Authors 2

Huntington F. Willard (first)
John R. Riordan (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:25 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 6, 2025, 8:08 a.m.)
Issued	39 years, 9 months ago (Nov. 22, 1985)
Published	39 years, 9 months ago (Nov. 22, 1985)
Published Print	39 years, 9 months ago (Nov. 22, 1985)

Funders 0

None

BibTeX

@article{Willard_1985, title={Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders}, volume={230}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3840606}, DOI={10.1126/science.3840606}, number={4728}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Willard, Huntington F. and Riordan, John R.}, year={1985}, month=nov, pages={940–942} }

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