DOI: 10.1126/science.3810169. Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

10.1126/science.3810169

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the β peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

Bibliography

Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987). Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimerâs Disease. Science, 235(4791), 877â880.

Authors 5

Dmitry Goldgaber (first)
Michael I. Lerman (additional)
O. Wesley McBride (additional)
Umberto Saffiotti (additional)
D. Carleton Gajdusek (additional)

References 26 Referenced 1,018

BAHMANYAR S unpublished data.
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BEYREUTHER, K, DISC NEUROSCI 3: 1 (1986). / DISC NEUROSCI (1986)
CHOU, P.Y., EMPIRICAL PREDICTIONS OF PROTEIN CONFORMATION, ANNUAL REVIEW OF BIOCHEMISTRY 47: 251 (1978). (10.1146/annurev.bi.47.070178.001343) / ANNUAL REVIEW OF BIOCHEMISTRY (1978)
DELABAR T.M. unpublished data.
GARNIER, J, ANALYSIS OF ACCURACY AND IMPLICATIONS OF SIMPLE METHODS FOR PREDICTING SECONDARY STRUCTURE OF GLOBULAR PROTEINS, JOURNAL OF MOLECULAR BIOLOGY 120: 97 (1978). (10.1016/0022-2836(78)90297-8) / JOURNAL OF MOLECULAR BIOLOGY (1978)
10.1016/0006-291X(84)91209-9
10.1056/NEJM198006053022305
Guiroy, D. C., Proceedings of the National Academy of Sciences of the United States of America 84: 2073 (1987). / Proceedings of the National Academy of Sciences of the United States of America (1987)
HUYNH, T.V., DNA CLONING TECHNIQU 1: 49 (1985). / DNA CLONING TECHNIQU (1985)
10.1016/0022-2836(82)90515-0
Maniatis T. Molecular Cloning: A Laboratory Manual (1982).
MASTERS, C.L., NEURONAL ORIGIN OF A CEREBRAL AMYLOID - NEUROFIBRILLARY TANGLES OF ALZHEIMERS-DISEASE CONTAIN THE SAME PROTEIN AS THE AMYLOID OF PLAQUE CORES AND BLOOD-VESSELS, EMBO JOURNAL 4: 2757 (1985). (10.1002/j.1460-2075.1985.tb04000.x) / EMBO JOURNAL (1985)
MCBRIDE, O.W., CHROMOSOMAL LOCATION OF HUMAN KAPPA AND LAMBDA-IMMUNOGLOBULIN LIGHT CHAIN CONSTANT REGION GENES, JOURNAL OF EXPERIMENTAL MEDICINE 155: 1480 (1982). (10.1084/jem.155.5.1480) / JOURNAL OF EXPERIMENTAL MEDICINE (1982)
MCBRIDE, O.W., LOCALIZATION OF HUMAN VARIABLE AND CONSTANT REGION IMMUNOGLOBULIN HEAVY-CHAIN GENES ON SUBTELOMERIC BAND-Q32 OF CHROMOSOME-14, NUCLEIC ACIDS RESEARCH 10: 8155 (1982). (10.1093/nar/10.24.8155) / NUCLEIC ACIDS RESEARCH (1982)
10.1073/pnas.83.1.130
OHTSUKA, E, AN ALTERNATIVE APPROACH TO DEOXYOLIGONUCLEOTIDES AS HYBRIDIZATION PROBES BY INSERTION OF DEOXYINOSINE AT AMBIGUOUS CODON POSITIONS, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 2605 (1985). (10.1016/S0021-9258(18)89400-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1985)
PUCHTLER, H, J HISTOCHEM CYTOCHEM 10: 335 (1962). / J HISTOCHEM CYTOCHEM (1962)
REED, K.C., RAPID TRANSFER OF DNA FROM AGAROSE GELS TO NYLON MEMBRANES, NUCLEIC ACIDS RESEARCH 13: 7207 (1985). (10.1093/nar/13.20.7207) / NUCLEIC ACIDS RESEARCH (1985)
RIGBY, PWJ, LABELING DEOXYRIBONUCLEIC-ACID TO HIGH SPECIFIC ACTIVITY INVITRO BY NICK TRANSLATION WITH DNA-POLYMERASE I, JOURNAL OF MOLECULAR BIOLOGY 113: 237 (1977). (10.1016/0022-2836(77)90052-3) / JOURNAL OF MOLECULAR BIOLOGY (1977)
RONIN, C, ENZYMATIC N-GLYCOSYLATION OF SYNTHETIC ASN-X-THR CONTAINING PEPTIDES, FEBS LETTERS 96: 179 (1978). (10.1016/0014-5793(78)81089-8) / FEBS LETTERS (1978)
10.1073/pnas.74.12.5463
10.1016/S0022-2836(75)80083-0
TAKAHASHI, Y, MOLECULAR-CLONING OF THE HUMAN CHOLECYSTOKININ GENE BY USE OF A SYNTHETIC PROBE CONTAINING DEOXYINOSINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 1931 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
10.1126/science.2949367
WONG, C.W., NEURITIC PLAQUES AND CEREBROVASCULAR AMYLOID IN ALZHEIMER-DISEASE ARE ANTIGENICALLY RELATED, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 8729 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:58 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 8:29 a.m.)
Issued	38 years, 6 months ago (Feb. 20, 1987)
Published	38 years, 6 months ago (Feb. 20, 1987)
Published Print	38 years, 6 months ago (Feb. 20, 1987)

Funders 0

None

BibTeX

@article{Goldgaber_1987, title={Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer’s Disease}, volume={235}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3810169}, DOI={10.1126/science.3810169}, number={4791}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Goldgaber, Dmitry and Lerman, Michael I. and McBride, O. Wesley and Saffiotti, Umberto and Gajdusek, D. Carleton}, year={1987}, month=feb, pages={877–880} }

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