DOI: 10.1126/science.3755548. Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

10.1126/science.3755548

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.

Bibliography

Coussens, L., Parker, P. J., Rhee, L., Yang-Feng, T. L., Chen, E., Waterfield, M. D., Francke, U., & Ullrich, A. (1986). Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways. Science, 233(4766), 859â866.

Authors 8

Lisa Coussens (first)
Peter J. Parker (additional)
Lucy Rhee (additional)
Teresa L. Yang-Feng (additional)
Ellson Chen (additional)
Michael D. Waterfield (additional)
Uta Francke (additional)
Axel Ullrich (additional)

References 34 Referenced 785

Barton, D. E., Human Genetics 72: 221 (1986). (10.1007/BF00291881) / Human Genetics (1986)
10.1038/312315a0
BLUNDELL, T.L., HORMONE FAMILIES - PANCREATIC HORMONES AND HOMOLOGOUS GROWTH-FACTORS, NATURE 287: 781 (1980). (10.1038/287781a0) / NATURE (1980)
CATHALA, G, A METHOD FOR ISOLATION OF INTACT, TRANSLATIONALLY ACTIVE RIBONUCLEIC-ACID, DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 2: 329 (1983). / DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY (1983)
10.1016/S0021-9258(17)43389-8
10.1126/science.2999974
COUSSENS L unpublished data.
DAYHOFF M.O. ATLAS PROTEIN SEQUEN 5 (1978).
DOWNES, P, MOL MECH TRANSMEMBRA: 3 (1985). / MOL MECH TRANSMEMBRA (1985)
FRANCKE, U, RANDOM-X INACTIVATION RESULTING IN MOSAIC NULLISOMY OF REGION XP21.1-]P21.3 ASSOCIATED WITH HETEROZYGOSITY FOR ORNITHINE TRANSCARBAMYLASE DEFICIENCY AND FOR CHRONIC GRANULOMATOUS-DISEASE, CYTOGENETICS AND CELL GENETICS 38: 298 (1984). (10.1159/000132078) / CYTOGENETICS AND CELL GENETICS (1984)
FRANCKE, U, ASSIGNMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX TO A REGION OF SHORT ARM OF HUMAN CHROMOSOME-6, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 1147 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
FRANCKE, U, INTRACHROMOSOMAL GENE MAPPING IN MAN - ASSIGNMENT OF NUCLEOSIDE PHOSPHORYLASE TO REGION 14CEN-]14Q21 BY INTERSPECIFIC HYBRIDIZATION OF CELLS WITH A T(X-14) (P22-Q21) TRANSLOCATION, SOMATIC CELL GENETICS 2: 27 (1976). (10.1007/BF01539240) / SOMATIC CELL GENETICS (1976)
FRANCKE, U, REQUIREMENT OF THE HUMAN CHROMOSOME-11 LONG ARM FOR REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN NON-PERMISSIVE CHINESE-HAMSTER X HUMAN-DIPLOID FIBROBLAST HYBRIDS, SOMATIC CELL GENETICS 7: 171 (1981). / SOMATIC CELL GENETICS (1981)
FRANKS, S, LINGUISTIC INQUIRY 14: 175 (1983). / LINGUISTIC INQUIRY (1983)
GRANTHAM, R, NUCLEIC ACIDS RES 9: 43 (1981). / NUCLEIC ACIDS RES (1981)
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HARPER, M.E., LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION, CHROMOSOMA 83: 431 (1981). (10.1007/BF00327364) / CHROMOSOMA (1981)
HUNTER, T, PROTEIN KINASE-C PHOSPHORYLATION OF THE EGF RECEPTOR AT A THREONINE RESIDUE CLOSE TO THE CYTOPLASMIC FACE OF THE PLASMA-MEMBRANE, NATURE 311: 480 (1984). (10.1038/311480a0) / NATURE (1984)
KOZAK, M, POSSIBLE ROLE OF FLANKING NUCLEOTIDES IN RECOGNITION OF THE AUG INITIATOR CODON BY EUKARYOTIC RIBOSOMES, NUCLEIC ACIDS RESEARCH 9: 5233 (1981). (10.1093/nar/9.20.5233) / NUCLEIC ACIDS RESEARCH (1981)
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LATHE, R, SYNTHETIC OLIGONUCLEOTIDE PROBES DEDUCED FROM AMINO-ACID SEQUENCE DATA - THEORETICAL AND PRACTICAL CONSIDERATIONS, JOURNAL OF MOLECULAR BIOLOGY 183: 1 (1985). (10.1016/0022-2836(85)90276-1) / JOURNAL OF MOLECULAR BIOLOGY (1985)
LEAVIS, P.C., THIN FILAMENT PROTEINS AND THIN FILAMENT-LINKED REGULATION OF VERTEBRATE MUSCLE-CONTRACTION, CRC CRITICAL REVIEWS IN BIOCHEMISTRY 16: 235 (1984). (10.3109/10409238409108717) / CRC CRITICAL REVIEWS IN BIOCHEMISTRY (1984)
LEHRACH, H, RNA MOLECULAR-WEIGHT DETERMINATIONS BY GEL-ELECTROPHORESIS UNDER DENATURING CONDITIONS, A CRITICAL RE-EXAMINATION, BIOCHEMISTRY 16: 4743 (1977). (10.1021/bi00640a033) / BIOCHEMISTRY (1977)
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ULLRICH, A, HUMAN INSULIN-RECEPTOR AND ITS RELATIONSHIP TO THE TYROSINE KINASE FAMILY OF ONCOGENES, NATURE 313: 756 (1985). (10.1038/313756a0) / NATURE (1985)
10.1126/science.3873110
10.1126/science.1257746

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:43 a.m.)
Indexed	1 week, 2 days ago (Aug. 23, 2025, 9:48 p.m.)
Issued	39 years ago (Aug. 22, 1986)
Published	39 years ago (Aug. 22, 1986)
Published Print	39 years ago (Aug. 22, 1986)

Funders 0

None

BibTeX

@article{Coussens_1986, title={Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways}, volume={233}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3755548}, DOI={10.1126/science.3755548}, number={4766}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Coussens, Lisa and Parker, Peter J. and Rhee, Lucy and Yang-Feng, Teresa L. and Chen, Ellson and Waterfield, Michael D. and Francke, Uta and Ullrich, Axel}, year={1986}, month=aug, pages={859–866} }

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        22
      ]
    ]
  },
  "references-count": 34,
  "journal-issue": {
    "issue": "4766",
    "published-print": {
      "date-parts": [
        [
          1986,
          8,
          22
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3755548"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3755548",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1986,
        8,
        22
      ]
    ]
  }
}