DOI: 10.1126/science.3749878. Effects of Alcohol on the Generation and Migration of Cerebral Cortical Neurons

Effects of Alcohol on the Generation and Migration of Cerebral Cortical Neurons

10.1126/science.3749878

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Prenatal exposure to alcohol produces many developmental defects of the central nervous system, such as microcephaly, mental retardation, motor dysfunction, and cognitive deficiencies. Therefore, the generation of neurons in the cerebral cortex was examined in the offspring of female rats fed a diet containing ethanol. Prenatal exposure to ethanol delayed and extended the period during which cortical neurons were generated, reduced the number of neurons in the mature cortex with the same time of origin, and altered the distribution of neurons generated on a particular day. Thus, the proliferation and migration of cortical neurons are profoundly affected by in utero exposure to ethanol.

Bibliography

Miller, M. W. (1986). Effects of Alcohol on the Generation and Migration of Cerebral Cortical Neurons. Science, 233(4770), 1308â1311.

Authors 1

Michael W. Miller (first)

References 31 Referenced 322

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ABEL, E.L., INUTERO ALCOHOL EXPOSURE - FUNCTIONAL AND STRUCTURAL BRAIN-DAMAGE, NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY 5: 363 (1983). / NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY (1983)
10.1038/192766b0
BERRY, M, MIGRATION OF NEUROBLASTS IN DEVELOPING CEREBRAL CORTEX, JOURNAL OF ANATOMY 99: 691 (1965). / JOURNAL OF ANATOMY (1965)
BESKID, M, HISTOCHEMICAL AND MORPHOLOGICAL EVALUATION OF CEREBRAL-CORTEX OF NEWBORN RAT IN THE COURSE OF JOINT ETHANOL AND PYRAZOLE ADMINISTRATION, ACTA HISTOCHEMICA 64: 89 (1979). (10.1016/S0065-1281(79)80057-4) / ACTA HISTOCHEMICA (1979)
10.1126/science.573922
CLARREN, S.K., FETAL ALCOHOL SYNDROME, NEW ENGLAND JOURNAL OF MEDICINE 298: 1063 (1978). (10.1056/NEJM197805112981906) / NEW ENGLAND JOURNAL OF MEDICINE (1978)
DONOGHUE, J.P., THE MOTOR CORTEX OF THE RAT - CYTOARCHITECTURE AND MICROSTIMULATION MAPPING, JOURNAL OF COMPARATIVE NEUROLOGY 212: 76 (1982). (10.1002/cne.902120106) / JOURNAL OF COMPARATIVE NEUROLOGY (1982)
FISHER, S.E., EFFECTS OF ACUTE ETHANOL EXPOSURE UPON INVIVO LEUCINE UPTAKE AND PROTEIN-SYNTHESIS IN THE FETAL-RAT, PEDIATRIC RESEARCH 15: 335 (1981). (10.1203/00006450-198104000-00009) / PEDIATRIC RESEARCH (1981)
HICKS, S.P., CELL MIGRATIONS TO ISOCORTEX IN RAT, ANATOMICAL RECORD 160: 619 (1968). (10.1002/ar.1091600311) / ANATOMICAL RECORD (1968)
JACOBSEN, S, CURR ALCOHOL 5: 123 (1979). / CURR ALCOHOL (1979)
KRONICK, J.B., TERATOGENIC EFFECTS OF ETHYL-ALCOHOL ADMINISTERED TO PREGNANT MICE, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 124: 676 (1976). (10.1016/S0002-9378(16)33334-8) / AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (1976)
MILLER, M.W., COGENERATION OF RETROGRADELY LABELED CORTICOCORTICAL PROJECTION AND GABA-IMMUNOREACTIVE LOCAL CIRCUIT NEURONS IN CEREBRAL-CORTEX, DEVELOPMENTAL BRAIN RESEARCH 23: 187 (1985). (10.1016/0165-3806(85)90040-9) / DEVELOPMENTAL BRAIN RESEARCH (1985)
MILLER, M.W., THE MIGRATION AND NEUROCHEMICAL DIFFERENTIATION OF GAMMA-AMINOBUTYRIC-ACID (GABA)-IMMUNOREACTIVE NEURONS IN RAT VISUAL-CORTEX AS DEMONSTRATED BY A COMBINED "IMMUNOCYTOCHEMICAL-AUTORADIOGRAPHIC TECHNIQUE, DEVELOPMENTAL BRAIN RESEARCH 28: 41 (1986). (10.1016/0165-3806(86)90063-5) / DEVELOPMENTAL BRAIN RESEARCH (1986)
Miller, M.W., Journal of Comparative Neurology 257: 372 (1987). (10.1002/cne.902570306) / Journal of Comparative Neurology (1987)
MILLER, M.W., DIRECT CONNECTIONS OF RAT VISUAL-CORTEX WITH SENSORY, MOTOR, AND ASSOCIATION CORTICES, JOURNAL OF COMPARATIVE NEUROLOGY 226: 184 (1984). (10.1002/cne.902260204) / JOURNAL OF COMPARATIVE NEUROLOGY (1984)
MILLER M.W. unpublished data.
PENTNEY, R.J., QUANTITATIVE MEASURES OF MATURE NEURONAL MORPHOLOGY AFTER INUTERO ETHANOL EXPOSURE, NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY 6: 59 (1984). / NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY (1984)
RANDALL, C.L., ETHANOL-INDUCED MALFORMATIONS IN MICE, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 1: 219 (1977). (10.1111/j.1530-0277.1977.tb05876.x) / ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (1977)
RAWAT, A.K., RIBOSOMAL-PROTEIN SYNTHESIS IN FETAL AND NEONATAL RAT-BRAIN AS INFLUENCED BY MATERNAL ETHANOL CONSUMPTION, RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 12: 723 (1975). / RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY (1975)
ROSETT, H.L., STRATEGIES FOR PREVENTION OF FETAL ALCOHOL EFFECTS, OBSTETRICS AND GYNECOLOGY 57: 1 (1981). / OBSTETRICS AND GYNECOLOGY (1981)
SHAPIRO, M.B., NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY 6: 351 (1984). / NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY (1984)
SHAYWITZ, S.E., BEHAVIOR AND LEARNING-DIFFICULTIES IN CHILDREN OF NORMAL INTELLIGENCE BORN TO ALCOHOLIC MOTHERS, JOURNAL OF PEDIATRICS 96: 978 (1980). (10.1016/S0022-3476(80)80621-4) / JOURNAL OF PEDIATRICS (1980)
SHIMADA, M, JOURNAL OF COMPARATIVE NEUROLOGY 139: 227 (1970). (10.1002/cne.901390206) / JOURNAL OF COMPARATIVE NEUROLOGY (1970)
Sidman, R. L., Contemporaty Research Methods in Neuroanatomy: 331 (1970). / Contemporaty Research Methods in Neuroanatomy (1970)
STOLTENBURGDIDI.G, FETAL ALCOHOL SYNDROME AND MENTAL-RETARDATION - SPINE DISTRIBUTION OF PYRAMIDAL CELLS IN PRENATAL ALCOHOL-EXPOSED RAT CEREBRAL-CORTEX - A GOLGI-STUDY, DEVELOPMENTAL BRAIN RESEARCH 11: 119 (1983). (10.1016/0165-3806(83)90206-7) / DEVELOPMENTAL BRAIN RESEARCH (1983)
WEST, J.R., THE EFFECT OF INUTERO ETHANOL EXPOSURE ON HIPPOCAMPAL MOSSY FIBERS - AN HRP STUDY, DEVELOPMENTAL BRAIN RESEARCH 15: 275 (1984). (10.1016/0165-3806(84)90104-4) / DEVELOPMENTAL BRAIN RESEARCH (1984)
WEST, J.R., PERMANENT HIPPOCAMPAL MOSSY FIBER HYPERDEVELOPMENT FOLLOWING PRENATAL ETHANOL EXPOSURE, NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY 5: 139 (1983). / NEUROBEHAVIORAL TOXICOLOGY AND TERATOLOGY (1983)
10.1126/science.7466371
WOODSON, P.M., EFFECT OF MATERNAL ALCOHOL-CONSUMPTION ON FETAL BRAIN-CELL NUMBER AND CELL-SIZE, NUTRITION REPORTS INTERNATIONAL 20: 225 (1979). / NUTRITION REPORTS INTERNATIONAL (1979)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:47 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 9:19 p.m.)
Issued	38 years, 11 months ago (Sept. 19, 1986)
Published	38 years, 11 months ago (Sept. 19, 1986)
Published Print	38 years, 11 months ago (Sept. 19, 1986)

Funders 0

None

BibTeX

@article{Miller_1986, title={Effects of Alcohol on the Generation and Migration of Cerebral Cortical Neurons}, volume={233}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3749878}, DOI={10.1126/science.3749878}, number={4770}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Miller, Michael W.}, year={1986}, month=sep, pages={1308–1311} }

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  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1986,
        9,
        19
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "4770",
    "published-print": {
      "date-parts": [
        [
          1986,
          9,
          19
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3749878"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3749878",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1986,
        9,
        19
      ]
    ]
  }
}