DOI: 10.1126/science.3686010. Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca <sup>2+</sup> ] <sub>i</sub>

Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca 2+ ] i

10.1126/science.3686010

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Recordings have been made of changes in intracellular calcium ion concentration ([Ca 2+ ] i ) that can be attributed to the operation of an electrogenic, voltage-dependent sodium-calcium (Na-Ca) exchanger in mammalian heart cells. Guinea pig ventricular myocytes under voltage clamp were perfused internally with fura-2, a fluorescent Ca 2+ -indicator, and changes in [Ca 2+ ] i and membrane current that resulted from Na-Ca exchange were identified through the use of various organic channel blockers and impermeant ions. Depolarization of cells elicited slow increases in [Ca 2+ ] i , with the maximum increase depending on internal [Na + ], external [Ca 2+ ], and membrane voltage. Repolarization was associated with net Ca 2+ efflux and a decline in the inward current that developed instantaneously upon repolarization. The relation between [Ca 2+ ] i and current was linear, and the slope was made steeper by hyperpolarization.

Bibliography

Barcenas-Ruiz, L., Beuckelmann, D. J., & Wier, W. G. (1987). Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca 2+ ] i. Science, 238(4834), 1720â1722.

Authors 3

L. Barcenas-Ruiz (first)
D. J. Beuckelmann (additional)
W. G. Wier (additional)

References 34 Referenced 114

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 5:22 a.m.)
Indexed	3 months, 1 week ago (May 23, 2025, 6:51 a.m.)
Issued	37 years, 8 months ago (Dec. 18, 1987)
Published	37 years, 8 months ago (Dec. 18, 1987)
Published Print	37 years, 8 months ago (Dec. 18, 1987)

Funders 0

None

BibTeX

@article{Barcenas_Ruiz_1987, title={Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca 2+ ] i}, volume={238}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3686010}, DOI={10.1126/science.3686010}, number={4834}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Barcenas-Ruiz, L. and Beuckelmann, D. J. and Wier, W. G.}, year={1987}, month=dec, pages={1720–1722} }

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