DOI: 10.1126/science.35829. β <sub>1</sub> - and β <sub>2</sub> -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated

β 1 - and β 2 -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated

10.1126/science.35829

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40 percent decrease in the density of β 1 -adrenergic receptors in the cerebral cortex but had no effect on the density of β 2 -adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64 percent increase in the density of β 1 -adrenergic receptors in adult cerebral cortex with no change in the density of β 2 -adrenergic receptors. These results suggest that the β-adrenergic receptors in rat cortex involved in neuronal function are primarily of the β 1 subtype.

Bibliography

Minneman, K. P., Dibner, M. D., Wolfe, B. B., & Molinoff, P. B. (1979). Î² 1 - and Î² 2 -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated. Science, 204(4395), 866â868.

Authors 4

Kenneth P. Minneman (first)
Mark D. Dibner (additional)
Barry B. Wolfe (additional)
Perry B. Molinoff (additional)

References 14 Referenced 261

AHLQUIST, R.P., PROG DRUG RES 20: 27 (1976). / PROG DRUG RES (1976)
BERG, D.K., BINDING OF ALPHA-BUNGAROTOXIN TO ACETYLCHOLINE RECEPTORS IN MAMMALIAN MUSCLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 147 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
10.1126/science.847477
FLEMING, W.W., POSTJUNCTIONAL SUPERSENSITIVITY AND SUBSENSITIVITY OF EXCITABLE TISSUES TO DRUGS, ERGEBNISSE DER PHYSIOLOGIE BIOLOGISCHEN CHEMIE UND EXPERIMENTELLEN PHARMAKOLOGIE 68: 55 (1973). / ERGEBNISSE DER PHYSIOLOGIE BIOLOGISCHEN CHEMIE UND EXPERIMENTELLEN PHARMAKOLOGIE (1973)
HARDEN, T.K., EFFECTS OF 6-HYDROXYDOPAMINE ON DEVELOPMENT OF BETA-ADRENERGIC RECEPTOR-ADENYLATE CYCLASE SYSTEM IN RAT CEREBRAL-CORTEX, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 203: 132 (1977). / JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1977)
HENRY, D.P., SENSITIVE RADIOENZYMATIC ASSAY FOR NOREPINEPHRINE IN TISSUES AND PLASMA, LIFE SCIENCES 16: 375 (1975). (10.1016/0024-3205(75)90258-1) / LIFE SCIENCES (1975)
LANDS, A.M., DIFFERENTIATION OF RECEPTOR SYSTEMS ACTIVATED BY SYMPATHOMIMETIC AMINES, NATURE 214: 597 (1967). (10.1038/214597a0) / NATURE (1967)
Minneman K. P. Catecholamines: Basic and Clinical Frontiers (1979).
Minneman, K. P., Molecular Pharmacology 16: 34 (1979). / Molecular Pharmacology (1979)
10.1111/j.1749-6632.1949.tb27297.x
10.1126/science.10626
UPRICHARD, D.C., BINDING CHARACTERISTICS OF A RADIOLABELED AGONIST AND ANTAGONIST AT CENTRAL NERVOUS-SYSTEM ALPHA NORADRENERGIC RECEPTORS, MOLECULAR PHARMACOLOGY 13: 454 (1977). / MOLECULAR PHARMACOLOGY (1977)
WOLFE, B.B., PRESYNAPTIC MODULATION OF BETA-ADRENERGIC RECEPTORS IN RAT CEREBRAL-CORTEX AFTER TREATMENT WITH ANTIDEPRESSANTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 207: 446 (1978). / JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1978)
ZATZ, M, EFFECTS OF CHOLERA TOXIN ON SUPERSENSITIVE AND SUB-SENSITIVE RAT PINEAL GLANDS - REGULATION OF SENSITIVITY AT MULTIPLE SITES, LIFE SCIENCES 21: 1267 (1977). (10.1016/0024-3205(77)90007-8) / LIFE SCIENCES (1977)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:53 a.m.)
Indexed	1 day, 23 hours ago (Sept. 4, 2025, 9:10 a.m.)
Issued	46 years, 3 months ago (May 25, 1979)
Published	46 years, 3 months ago (May 25, 1979)
Published Print	46 years, 3 months ago (May 25, 1979)

Funders 0

None

BibTeX

@article{Minneman_1979, title={β 1 - and β 2 -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated}, volume={204}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.35829}, DOI={10.1126/science.35829}, number={4395}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Minneman, Kenneth P. and Dibner, Mark D. and Wolfe, Barry B. and Molinoff, Perry B.}, year={1979}, month=may, pages={866–868} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:10:41Z",
    "timestamp": 1756991441896
  },
  "reference-count": 14,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4395",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1979,
        5,
        25
      ]
    ]
  },
  "abstract": "<jats:p>\n            Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40 percent decrease in the density of \u03b2\n            <jats:sub>1</jats:sub>\n            -adrenergic receptors in the cerebral cortex but had no effect on the density of \u03b2\n            <jats:sub>2</jats:sub>\n            -adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64 percent increase in the density of \u03b2\n            <jats:sub>1</jats:sub>\n            -adrenergic receptors in adult cerebral cortex with no change in the density of \u03b2\n            <jats:sub>2</jats:sub>\n            -adrenergic receptors. These results suggest that the \u03b2-adrenergic receptors in rat cortex involved in neuronal function are primarily of the \u03b2\n            <jats:sub>1</jats:sub>\n            subtype.\n          </jats:p>",
  "DOI": "10.1126/science.35829",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T16:39:42Z",
    "timestamp": 1160066382000
  },
  "page": "866-868",
  "source": "Crossref",
  "is-referenced-by-count": 261,
  "title": "\u03b2\n            <sub>1</sub>\n            - and \u03b2\n            <sub>2</sub>\n            -Adrenergic Receptors in Rat Cerebral Cortex Are Independently Regulated",
  "prefix": "10.1126",
  "volume": "204",
  "author": [
    {
      "given": "Kenneth P.",
      "family": "Minneman",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Pharmacology, University of Colorado Medical Center, Denver 80262"
        }
      ]
    },
    {
      "given": "Mark D.",
      "family": "Dibner",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pharmacology, University of Colorado Medical Center, Denver 80262"
        }
      ]
    },
    {
      "given": "Barry B.",
      "family": "Wolfe",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pharmacology, University of Colorado Medical Center, Denver 80262"
        }
      ]
    },
    {
      "given": "Perry B.",
      "family": "Molinoff",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pharmacology, University of Colorado Medical Center, Denver 80262"
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "first-page": "27",
      "volume": "20",
      "year": "1976",
      "unstructured": "AHLQUIST, R.P., PROG DRUG RES 20: 27 (1976).",
      "journal-title": "PROG DRUG RES"
    },
    {
      "key": "e_1_2_1_2_1",
      "first-page": "147",
      "volume": "69",
      "year": "1972",
      "unstructured": "BERG, D.K., BINDING OF ALPHA-BUNGAROTOXIN TO ACETYLCHOLINE RECEPTORS IN MAMMALIAN MUSCLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 147 (1972).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.847477"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "55",
      "volume": "68",
      "year": "1973",
      "unstructured": "FLEMING, W.W., POSTJUNCTIONAL SUPERSENSITIVITY AND SUBSENSITIVITY OF EXCITABLE TISSUES TO DRUGS, ERGEBNISSE DER PHYSIOLOGIE BIOLOGISCHEN CHEMIE UND EXPERIMENTELLEN PHARMAKOLOGIE 68: 55 (1973).",
      "journal-title": "ERGEBNISSE DER PHYSIOLOGIE BIOLOGISCHEN CHEMIE UND EXPERIMENTELLEN PHARMAKOLOGIE"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "132",
      "volume": "203",
      "year": "1977",
      "unstructured": "HARDEN, T.K., EFFECTS OF 6-HYDROXYDOPAMINE ON DEVELOPMENT OF BETA-ADRENERGIC RECEPTOR-ADENYLATE CYCLASE SYSTEM IN RAT CEREBRAL-CORTEX, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 203: 132 (1977).",
      "journal-title": "JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1016/0024-3205(75)90258-1",
      "volume": "16",
      "year": "1975",
      "unstructured": "HENRY, D.P., SENSITIVE RADIOENZYMATIC ASSAY FOR NOREPINEPHRINE IN TISSUES AND PLASMA, LIFE SCIENCES 16: 375 (1975).",
      "journal-title": "LIFE SCIENCES"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "first-page": "597",
      "DOI": "10.1038/214597a0",
      "volume": "214",
      "year": "1967",
      "unstructured": "LANDS, A.M., DIFFERENTIATION OF RECEPTOR SYSTEMS ACTIVATED BY SYMPATHOMIMETIC AMINES, NATURE 214: 597 (1967).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_8_1",
      "unstructured": "Minneman K. P. Catecholamines: Basic and Clinical Frontiers (1979)."
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "34",
      "volume": "16",
      "year": "1979",
      "unstructured": "Minneman, K. P., Molecular Pharmacology 16: 34 (1979).",
      "journal-title": "Molecular Pharmacology"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1949.tb27297.x"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.10626"
    },
    {
      "key": "e_1_2_1_12_1",
      "first-page": "454",
      "volume": "13",
      "year": "1977",
      "unstructured": "UPRICHARD, D.C., BINDING CHARACTERISTICS OF A RADIOLABELED AGONIST AND ANTAGONIST AT CENTRAL NERVOUS-SYSTEM ALPHA NORADRENERGIC RECEPTORS, MOLECULAR PHARMACOLOGY 13: 454 (1977).",
      "journal-title": "MOLECULAR PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_13_1",
      "first-page": "446",
      "volume": "207",
      "year": "1978",
      "unstructured": "WOLFE, B.B., PRESYNAPTIC MODULATION OF BETA-ADRENERGIC RECEPTORS IN RAT CEREBRAL-CORTEX AFTER TREATMENT WITH ANTIDEPRESSANTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 207: 446 (1978).",
      "journal-title": "JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "1267",
      "DOI": "10.1016/0024-3205(77)90007-8",
      "volume": "21",
      "year": "1977",
      "unstructured": "ZATZ, M, EFFECTS OF CHOLERA TOXIN ON SUPERSENSITIVE AND SUB-SENSITIVE RAT PINEAL GLANDS - REGULATION OF SENSITIVITY AT MULTIPLE SITES, LIFE SCIENCES 21: 1267 (1977).",
      "journal-title": "LIFE SCIENCES"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.35829",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        14
      ]
    ],
    "date-time": "2024-01-14T09:53:34Z",
    "timestamp": 1705226014000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.35829"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1979,
        5,
        25
      ]
    ]
  },
  "references-count": 14,
  "journal-issue": {
    "issue": "4395",
    "published-print": {
      "date-parts": [
        [
          1979,
          5,
          25
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.35829"
  ],
  "URL": "http://dx.doi.org/10.1126/science.35829",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1979,
        5,
        25
      ]
    ]
  }
}