DOI: 10.1126/science.3547648. CDC25 : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae [Penn]

CDC25 : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae

10.1126/science.3547648

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The yeast Saccharomyces cerevisiae contains two functional homologues of the ras oncogene family, RAS1 and RAS2 . These genes are required for growth, and all evidence indicates that this essential function is the activation of adenylate cyclase. In contrast, ras in mammalian cells does not appear to influence adenylate cyclase activity. To clarify the relation between ras function in yeast and in higher eukaryotes, and the role played by yeast ras in growth control, it is necessary to identify functions acting upstream of ras in the adenylate cyclase pathway. The evidence presented here indicates that CDC25 , identified by conditional cell cycle arrest mutations, encodes such an upstream function.

Bibliography

Robinson, L. C., Gibbs, J. B., Marshall, M. S., Sigal, I. S., & Tatchell, K. (1987). CDC25 â¯: a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae. Science, 235(4793), 1218â1221.

Authors 5

Lucy C. Robinson (first)
Jackson B. Gibbs (additional)
Mark S. Marshall (additional)
Irving S. Sigal (additional)
Kelly Tatchell (additional)

References 33 Referenced 183

10.1016/0092-8674(85)90280-6
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 4:57 a.m.)
Indexed	4 months, 2 weeks ago (April 9, 2025, 7:30 a.m.)
Issued	38 years, 5 months ago (March 6, 1987)
Published	38 years, 5 months ago (March 6, 1987)
Published Print	38 years, 5 months ago (March 6, 1987)

Funders 0

None

BibTeX

@article{Robinson_1987, title={CDC25  : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae}, volume={235}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3547648}, DOI={10.1126/science.3547648}, number={4793}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Robinson, Lucy C. and Gibbs, Jackson B. and Marshall, Mark S. and Sigal, Irving S. and Tatchell, Kelly}, year={1987}, month=mar, pages={1218–1221} }

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