DOI: 10.1126/science.3492043. Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

10.1126/science.3492043

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.

Bibliography

Stern, D. F., Hare, D. L., Cecchini, M. A., & Weinberg, R. A. (1987). Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor. Science, 235(4786), 321â324.

Authors 4

D. F. Stern (first)
D. L. Hare (additional)
M. A. Cecchini (additional)
R. A. Weinberg (additional)

References 31 Referenced 102

ADAMSON, E.D., EPIDERMAL GROWTH-FACTOR RECEPTORS, MOLECULAR AND CELLULAR BIOCHEMISTRY 34: 129 (1981). (10.1007/BF02359619) / MOLECULAR AND CELLULAR BIOCHEMISTRY (1981)
ADKINS, B, AUTOCRINE GROWTH INDUCED BY SRC-RELATED ONCOGENES IN TRANSFORMED CHICKEN MYELOID CELLS, CELL 39: 439 (1984). (10.1016/0092-8674(84)90451-3) / CELL (1984)
BARGMANN, C.I., THE NEU ONCOGENE ENCODES AN EPIDERMAL GROWTH-FACTOR RECEPTOR-RELATED PROTEIN, NATURE 319: 226 (1986). (10.1038/319226a0) / NATURE (1986)
BARNES, D, STIMULATION OF SUGAR UPTAKE IN CULTURED FIBROBLASTS BY EPIDERMAL GROWTH-FACTOR (EGF) AND EGF-BINDING ARGININE ESTERASE, JOURNAL OF CELLULAR PHYSIOLOGY 89: 633 (1976). (10.1002/jcp.1040890420) / JOURNAL OF CELLULAR PHYSIOLOGY (1976)
CARPENTER, G, EPIDERMAL GROWTH-FACTOR, ANNUAL REVIEW OF BIOCHEMISTRY 48: 193 (1979). (10.1146/annurev.bi.48.070179.001205) / ANNUAL REVIEW OF BIOCHEMISTRY (1979)
COUSSENS, L, STRUCTURAL ALTERATION OF VIRAL HOMOLOG OF RECEPTOR PROTOONCOGENE FMS AT CARBOXYL TERMINUS, NATURE 320: 277 (1986). (10.1038/320277a0) / NATURE (1986)
10.1038/316823a0
DALBADIEMCFARLA.G, OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS AS A GENERAL AND POWERFUL METHOD FOR STUDIES OF PROTEIN FUNCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 6409 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
DELARCO, J.E., SARCOMA GROWTH-FACTOR (SGF) - SPECIFIC BINDING TO EPIDERMAL GROWTH-FACTOR (EGF) MEMBRANE-RECEPTORS, JOURNAL OF CELLULAR PHYSIOLOGY 102: 267 (1980). (10.1002/jcp.1041020218) / JOURNAL OF CELLULAR PHYSIOLOGY (1980)
DELARCO, J.E., GROWTH-FACTORS FROM MURINE SARCOMA VIRUS-TRANSFORMED CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 4001 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
DOWNWARD, J, AUTOPHOSPHORYLATION SITES ON THE EPIDERMAL GROWTH-FACTOR RECEPTOR, NATURE 311: 483 (1984). (10.1038/311483a0) / NATURE (1984)
GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983). (10.1038/303722a0) / NATURE (1983)
HARE, D.L., JOURNAL OF CELLULAR BIOCHEMISTRY 26 8A: 87 (1984). / JOURNAL OF CELLULAR BIOCHEMISTRY (1984)
10.1016/0092-8674(84)90296-4
JOHNSSON, A, ANTIBODIES AGAINST PLATELET-DERIVED GROWTH-FACTOR INHIBIT ACUTE TRANSFORMATION BY SIMIAN SARCOMA-VIRUS, NATURE 317: 438 (1985). (10.1038/317438a0) / NATURE (1985)
LAND, H, TUMORIGENIC CONVERSION OF PRIMARY EMBRYO FIBROBLASTS REQUIRES AT LEAST 2 COOPERATING ONCOGENES, NATURE 304: 596 (1983). (10.1038/304596a0) / NATURE (1983)
LANG, R.A., EXPRESSION OF A HEMATOPOIETIC GROWTH-FACTOR CDNA IN A FACTOR-DEPENDENT CELL-LINE RESULTS IN AUTONOMOUS GROWTH AND TUMORIGENICITY, CELL 43: 531 (1985). (10.1016/0092-8674(85)90182-5) / CELL (1985)
LOH, D.Y., MOLECULAR-BASIS OF A MOUSE STRAIN-SPECIFIC ANTI-HAPTEN RESPONSE, CELL 33: 85 (1983). (10.1016/0092-8674(83)90337-9) / CELL (1983)
10.1073/pnas.68.11.2739
NICOLSON M COMMUNICATION.
OZANNE, B, KIRSTEN MURINE SARCOMA-VIRUS TRANSFORMED-CELL LINES AND A SPONTANEOUSLY TRANSFORMED RAT CELL-LINE PRODUCE TRANSFORMING FACTORS, JOURNAL OF CELLULAR PHYSIOLOGY 105: 163 (1980). (10.1002/jcp.1041050118) / JOURNAL OF CELLULAR PHYSIOLOGY (1980)
ROBERTS, A.B., TRANSFORMING GROWTH-FACTORS, CANCER SURVEYS 4: 683 (1985). / CANCER SURVEYS (1985)
ROBERTS, A.B., TYPE-BETA TRANSFORMING GROWTH-FACTOR - A BIFUNCTIONAL REGULATOR OF CELLULAR GROWTH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 119 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
ROSENTHAL, A, EXPRESSION IN RAT FIBROBLASTS OF A HUMAN TRANSFORMING GROWTH FACTOR-ALPHA CDNA RESULTS IN TRANSFORMATION, CELL 46: 301 (1986). (10.1016/0092-8674(86)90747-6) / CELL (1986)
10.1126/science.6602382
SHERR, C.J., THE C-FMS PROTO-ONCOGENE PRODUCT IS RELATED TO THE RECEPTOR FOR THE MONONUCLEAR PHAGOCYTE GROWTH-FACTOR, CSF-1, CELL 41: 665 (1985). (10.1016/S0092-8674(85)80047-7) / CELL (1985)
SMITH, J, CHEMICAL SYNTHESIS AND CLONING OF A GENE FOR HUMAN BETA-UROGASTRONE, NUCLEIC ACIDS RESEARCH 10: 4467 (1982). (10.1093/nar/10.15.4467) / NUCLEIC ACIDS RESEARCH (1982)
10.1038/313745a0
SPORN, M.B., AUTOCRINE SECRETION AND MALIGNANT TRANSFORMATION OF CELLS, NEW ENGLAND JOURNAL OF MEDICINE 303: 878 (1980). (10.1056/NEJM198010093031511) / NEW ENGLAND JOURNAL OF MEDICINE (1980)
STERN, D.F., MOLECULAR AND CELLULAR BIOLOGY 6: 870 (1986). / MOLECULAR AND CELLULAR BIOLOGY (1986)
10.1038/304035a0

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:21 p.m.)
Indexed	4 months, 2 weeks ago (April 10, 2025, 9:45 a.m.)
Issued	38 years, 7 months ago (Jan. 16, 1987)
Published	38 years, 7 months ago (Jan. 16, 1987)
Published Print	38 years, 7 months ago (Jan. 16, 1987)

Funders 0

None

BibTeX

@article{Stern_1987, title={Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor}, volume={235}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3492043}, DOI={10.1126/science.3492043}, number={4786}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Stern, D. F. and Hare, D. L. and Cecchini, M. A. and Weinberg, R. A.}, year={1987}, month=jan, pages={321–324} }

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  "alternative-id": [
    "10.1126/science.3492043"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3492043",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1987,
        1,
        16
      ]
    ]
  }
}