DOI: 10.1126/science.3487832. The Oncogenic Activation of Human p21 <sup> <i>ras</i> </sup> by a Novel Mechanism

The Oncogenic Activation of Human p21 ras by a Novel Mechanism

10.1126/science.3487832

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Single amino acid changes were introduced into normal (non-oncogenic) and activated forms of the human H- ras protein at a position (residue 116) proposed on structural grounds to represent a contact site with guanine nucleotides. Substitutions at this site could significantly reduce the ability of both forms to bind and hydrolyze guanosine 5′-triphosphate; these substitutions, however, did not necessarily diminish the transforming capacity of activated derivatives. One substitution that severely impairs these functions activated the transforming potential of the otherwise normal polypeptide.

Bibliography

Walter, M., Clark, S. G., & Levinson, A. D. (1986). The Oncogenic Activation of Human p21 ras by a Novel Mechanism. Science, 233(4764), 649â652.

Authors 3

Maureen Walter (first)
Scott G. Clark (additional)
Arthur D. Levinson (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:47 p.m.)
Indexed	1 month ago (July 28, 2025, 2:26 a.m.)
Issued	39 years ago (Aug. 8, 1986)
Published	39 years ago (Aug. 8, 1986)
Published Print	39 years ago (Aug. 8, 1986)

Funders 0

None

BibTeX

@article{Walter_1986, title={The Oncogenic Activation of Human p21 ras by a Novel Mechanism}, volume={233}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3487832}, DOI={10.1126/science.3487832}, number={4764}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Walter, Maureen and Clark, Scott G. and Levinson, Arthur D.}, year={1986}, month=aug, pages={649–652} }

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