DOI: 10.1126/science.3399891. Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

10.1126/science.3399891

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Neurons that release serotonin as a neurotransmitter project to most regions of the central and peripheral nervous system and mediate diverse neural functions. The physiological effects of serotonin are initiated by the activation of multiple, distinct receptor subtypes. Cloning in RNA expression vectors was combined with a sensitive electrophysiological assay in Xenopus oocytes in order to isolate a functional cDNA clone encoding the 5HTlc serotonin receptor. Injection of RNA transcribed in vitro from this clone into Xenopus oocytes elicits serotonin sensitivity. Mouse fibroblasts transformed with this clone bind serotonin agonists and antagonists and exhibit an increase in intracellular Ca 2+ concentrations in response to serotonin. The sequence of the 5HTlc receptor reveals that it belongs to the family of G protein-coupled receptors, which are thought to traverse the cytoplasmic membrane seven times. Moreover, in situ hybridization and RNA blot analysis indicate that the 5HTlc receptor is expressed in neurons in many regions of the central nervous system and suggest that this subclass of receptor may mediate many of the central actions of serotonin.

Bibliography

Julius, D., MacDermott, A. B., Axel, R., & Jessell, T. M. (1988). Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor. Science, 241(4865), 558â564.

Authors 4

David Julius (first)
Amy B. MacDermott (additional)
Richard Axel (additional)
Thomas M. Jessell (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:09 p.m.)
Indexed	1 day, 8 hours ago (Sept. 4, 2025, 9:57 a.m.)
Issued	37 years, 1 month ago (July 29, 1988)
Published	37 years, 1 month ago (July 29, 1988)
Published Print	37 years, 1 month ago (July 29, 1988)

Funders 0

None

BibTeX

@article{Julius_1988, title={Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor}, volume={241}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3399891}, DOI={10.1126/science.3399891}, number={4865}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Julius, David and MacDermott, Amy B. and Axel, Richard and Jessell, Thomas M.}, year={1988}, month=jul, pages={558–564} }

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