A Molecular Basis for MHC Class II—Associated Autoimmunity
10.1126/science.3368786
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.

Bibliography

Todd, J. A., Acha-Orbea, H., Bell, J. I., Chao, N., Fronek, Z., Jacob, C. O., McDermott, M., Sinha, A. A., Timmerman, L., Steinman, L., & McDevitt, H. O. (1988). A Molecular Basis for MHC Class II—Associated Autoimmunity. Science, 240(4855), 1003–1009.

Authors 11
  1. John A. Todd (first)
  2. Hans Acha-Orbea (additional)
  3. John I. Bell (additional)
  4. Nelson Chao (additional)
  5. Zdenka Fronek (additional)
  6. Chaim O. Jacob (additional)
  7. Michael McDermott (additional)
  8. Animesh A. Sinha (additional)
  9. Luika Timmerman (additional)
  10. Lawrence Steinman (additional)
  11. Hugh O. McDevitt (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 10:19 p.m.)
Indexed 1 hour, 4 minutes ago (Sept. 4, 2025, 5:30 a.m.)
Issued 37 years, 3 months ago (May 20, 1988)
Published 37 years, 3 months ago (May 20, 1988)
Published Print 37 years, 3 months ago (May 20, 1988)
Funders 0

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@article{Todd_1988, title={A Molecular Basis for MHC Class II—Associated Autoimmunity}, volume={240}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3368786}, DOI={10.1126/science.3368786}, number={4855}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Todd, John A. and Acha-Orbea, Hans and Bell, John I. and Chao, Nelson and Fronek, Zdenka and Jacob, Chaim O. and McDermott, Michael and Sinha, Animesh A. and Timmerman, Luika and Steinman, Lawrence and McDevitt, Hugh O.}, year={1988}, month=may, pages={1003–1009} }