DOI: 10.1126/science.3303333. Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

10.1126/science.3303333

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Non-insulin-dependent diabetes mellitus is an increasingly prevalent disease in Western and developing societies. A major metabolic abnormality of non-insulin-dependent diabetes is impaired insulin action (insulin resistance). Diets high in fat from vegetable and nonaquatic animal sources (rich in linoleic acid, an ω-6 fatty acid, and saturated fats) lead to insulin resistance. In rats fed high-fat diets, replacement of only 6 percent of the linoleic ω-6 fatty acids from safflower oil with long-chain polyunsaturated ω-3 fatty acids from fish oil prevented the development of insulin resistance. The effect was most pronounced in the liver and skeletal muscle, which have important roles in glucose supply and demand. The results may be important for therapy or prevention of non-insulin-dependent diabetes mellitus.

Bibliography

Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987). Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats. Science, 237(4817), 885â888.

Authors 6

Leonard H. Storlien (first)
Edward W. Kraegen (additional)
Donald J. Chisholm (additional)
Glenn L. Ford (additional)
David G. Bruce (additional)
Wendy S. Pascoe (additional)

References 19 Referenced 511

DEFRONZO, R. A., AMERICAN JOURNAL OF PHYSIOLOGY 237: E214 (1979). / AMERICAN JOURNAL OF PHYSIOLOGY (1979)
FELIG, P, INSULIN IS THE MEDIATOR OF FEEDING-RELATED THERMOGENESIS - INSULIN RESISTANCE AND OR DEFICIENCY RESULTS IN A THERMOGENIC DEFECT WHICH CONTRIBUTES TO THE PATHOGENESIS OF OBESITY, CLINICAL PHYSIOLOGY 4: 267 (1984). (10.1111/j.1475-097X.1984.tb00802.x) / CLINICAL PHYSIOLOGY (1984)
HARRIS, W.S., TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS 43: 148 (1980). / TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS (1980)
JAMES, D. E., AMERICAN JOURNAL OF PHYSIOLOGY 248: E567 (1985). / AMERICAN JOURNAL OF PHYSIOLOGY (1985)
JAMES, D. E., AMERICAN JOURNAL OF PHYSIOLOGY 251: E422 (1986). / AMERICAN JOURNAL OF PHYSIOLOGY (1986)
JAMES, D.E., INVIVO GLUCOSE-METABOLISM IN INDIVIDUAL TISSUES OF THE RAT - INTERACTION BETWEEN EPINEPHRINE AND INSULIN, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 6366 (1986). (10.1016/S0021-9258(19)84571-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1986)
KAHN, C.R., INSULIN RESISTANCE - A COMMON FEATURE OF DIABETES-MELLITUS, NEW ENGLAND JOURNAL OF MEDICINE 315: 252 (1986). (10.1056/NEJM198607243150410) / NEW ENGLAND JOURNAL OF MEDICINE (1986)
KAMADA, T, DIETARY SARDINE OIL INCREASES ERYTHROCYTE-MEMBRANE FLUIDITY IN DIABETIC-PATIENTS, DIABETES 35: 604 (1986). (10.2337/diab.35.5.604) / DIABETES (1986)
KEYS, A, THE DIET AND ALL-CAUSES DEATH RATE IN THE 7 COUNTRIES STUDY, LANCET 2: 58 (1981). / LANCET (1981)
KRAEGEN, E. W., AMERICAN JOURNAL OF PHYSIOLOGY 248: E353 (1985). / AMERICAN JOURNAL OF PHYSIOLOGY (1985)
KRAEGEN, E.W., INVIVO INSULIN RESISTANCE IN INDIVIDUAL PERIPHERAL-TISSUES OF THE HIGH-FAT FED RAT - ASSESSMENT BY EUGLYCEMIC CLAMP PLUS DEOXYGLUCOSE ADMINISTRATION, DIABETOLOGIA 29: 192 (1986). (10.1007/BF02427092) / DIABETOLOGIA (1986)
KROMHOUT, D, NEW ENGLAND JOURNAL OF MEDICINE 312: 1205 (1985). (10.1056/NEJM198505093121901) / NEW ENGLAND JOURNAL OF MEDICINE (1985)
MOURATOFF, G.J., JAMA-J AM MED ASSOC 199: 107 (1967). (10.1001/jama.199.13.107) / JAMA-J AM MED ASSOC (1967)
NEUFELD, N.D., INSULIN-RECEPTOR DEVELOPMENT IN NORMAL AND DIABETIC PREGNANCIES - ROLE OF MEMBRANE FLUIDITY, DIABETES 35: 1020 (1986). (10.2337/diab.35.9.1020) / DIABETES (1986)
PHILLIPSON, B.E., REDUCTION OF PLASMA-LIPIDS, LIPOPROTEINS, AND APOPROTEINS BY DIETARY FISH OILS IN PATIENTS WITH HYPERTRIGLYCERIDEMIA, NEW ENGLAND JOURNAL OF MEDICINE 312: 1210 (1985). (10.1056/NEJM198505093121902) / NEW ENGLAND JOURNAL OF MEDICINE (1985)
Sinclair, H. M., Nutrition and Killer Diseases: 69 (1982). / Nutrition and Killer Diseases (1982)
STORLIEN, L. H., AMERICAN JOURNAL OF PHYSIOLOGY 251: E576 (1986). / AMERICAN JOURNAL OF PHYSIOLOGY (1986)
Willis, A. L., Nutrition Reviews Present Knowledge in Nutrition: 90 (1984). / Nutrition Reviews Present Knowledge in Nutrition (1984)
WONG, S.H., THE ADAPTIVE EFFECTS OF DIETARY FISH AND SAFFLOWER OIL ON LIPID AND LIPOPROTEIN METABOLISM IN PERFUSED-RAT-LIVER, BIOCHIMICA ET BIOPHYSICA ACTA 792: 103 (1984). (10.1016/0005-2760(84)90209-1) / BIOCHIMICA ET BIOPHYSICA ACTA (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:37 p.m.)
Indexed	2 hours, 23 minutes ago (Sept. 3, 2025, 6:30 a.m.)
Issued	38 years ago (Aug. 21, 1987)
Published	38 years ago (Aug. 21, 1987)
Published Print	38 years ago (Aug. 21, 1987)

Funders 0

None

BibTeX

@article{Storlien_1987, title={Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats}, volume={237}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3303333}, DOI={10.1126/science.3303333}, number={4817}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Storlien, Leonard H. and Kraegen, Edward W. and Chisholm, Donald J. and Ford, Glenn L. and Bruce, David G. and Pascoe, Wendy S.}, year={1987}, month=aug, pages={885–888} }

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