DOI: 10.1126/science.3262237. Effects of Cyclosporine A on T Cell Development and Clonal Deletion

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

10.1126/science.3262237

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cyclosporine A (CsA) is an important immunosuppressive drug that is widely used in transplantation medicine. Many of its suppressive effects on T cells appear to be related to the inhibition of T cell receptor (TCR)-mediated activation events. Paradoxically, in certain situations CsA is responsible for the induction of a T cell-mediated autoimmunity. The effects of CsA on T cell development in the thymus were investigated to elucidate the physiologic events underlying this phenomenon. Two major effects were revealed: (i) CsA inhibits the development of mature single positive (CD4 + 8 - or CD4 - 8 + ) TCR-α β + thymocytes without discernibly affecting CD4 - 8 - TCR-γδ + thymocytes and (ii) CsA interferes with the deletion of cells bearing self-reactive TCRs in the population of single positive thymocytes that do develop. This suggests a direct mechanism for CsA-induced autoimmunity and may have implications for the relative contribution of TCR-mediated signaling events in the development of the various T cell lineages.

Bibliography

Jenkins, M. K., Schwartz, R. H., & Pardoll, D. M. (1988). Effects of Cyclosporine A on T Cell Development and Clonal Deletion. Science, 241(4873), 1655â1658.

Authors 3

Marc K. Jenkins (first)
Ronald H. Schwartz (additional)
Drew M. Pardoll (additional)

References 43 Referenced 256

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:04 p.m.)
Indexed	3 months ago (May 28, 2025, 1:06 p.m.)
Issued	36 years, 11 months ago (Sept. 23, 1988)
Published	36 years, 11 months ago (Sept. 23, 1988)
Published Print	36 years, 11 months ago (Sept. 23, 1988)

Funders 0

None

BibTeX

@article{Jenkins_1988, title={Effects of Cyclosporine A on T Cell Development and Clonal Deletion}, volume={241}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3262237}, DOI={10.1126/science.3262237}, number={4873}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Jenkins, Marc K. and Schwartz, Ronald H. and Pardoll, Drew M.}, year={1988}, month=sep, pages={1655–1658} }

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