DOI: 10.1126/science.3259727. Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

10.1126/science.3259727

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.

Bibliography

Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988). Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling. Science, 240(4858), 1546â1548.

Authors 5

Helen Vlassara (first)
Michael Brownlee (additional)
Kirk R. Manogue (additional)
Charles A. Dinarello (additional)
Araxi Pasagian (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 1:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 5:24 p.m.)
Indexed	1 day, 15 hours ago (Sept. 4, 2025, 9:38 a.m.)
Issued	37 years, 2 months ago (June 10, 1988)
Published	37 years, 2 months ago (June 10, 1988)
Published Print	37 years, 2 months ago (June 10, 1988)

Funders 0

None

BibTeX

@article{Vlassara_1988, title={Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling}, volume={240}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3259727}, DOI={10.1126/science.3259727}, number={4858}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Vlassara, Helen and Brownlee, Michael and Manogue, Kirk R. and Dinarello, Charles A. and Pasagian, Araxi}, year={1988}, month=jun, pages={1546–1548} }

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