DOI: 10.1126/science.3118464. Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

10.1126/science.3118464

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The Drosophila gene, dorsal , is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The dorsal protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v- rel , its cellular homolog, c- rel , and a human c- rel fragment. The oncogene v- rel is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.

Bibliography

Steward, R. (1987). Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel. Science, 238(4827), 692â694.

Authors 1

Ruth Steward (first)

References 32 Referenced 360

ANDERSON, K.V., ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT, CELL 42: 779 (1985). (10.1016/0092-8674(85)90274-0) / CELL (1985)
Anderson, K. V., Gametogenesis and the Early Embryo: 177 (1986). / Gametogenesis and the Early Embryo (1986)
ANDERSON, K.V., INFORMATION FOR THE DORSAL VENTRAL PATTERN OF THE DROSOPHILA EMBRYO IS STORED AS MATERNAL MESSENGER-RNA, NATURE 311: 223 (1984). (10.1038/311223a0) / NATURE (1984)
Anderson, K. V., Primers in Developmental Biology: 269 (1984). / Primers in Developmental Biology (1984)
ANDERSON, K.V., DORSAL VENTRAL EMBRYONIC PATTERN GENES OF DROSOPHILA, TRENDS IN GENETICS 3: 91 (1987). (10.1016/0168-9525(87)90191-0) / TRENDS IN GENETICS (1987)
BEUG, H, HEMATOPOIETIC-CELLS TRANSFORMED INVITRO BY REVT AVIAN RETICULOENDOTHELIOSIS VIRUS EXPRESS CHARACTERISTICS OF VERY IMMATURE LYMPHOID-CELLS, VIROLOGY 115: 295 (1981). (10.1016/0042-6822(81)90112-4) / VIROLOGY (1981)
BROWNELL, E, GENETIC-CHARACTERIZATION OF HUMAN C-REL SEQUENCES, MOLECULAR AND CELLULAR BIOLOGY 5: 2826 (1985). / MOLECULAR AND CELLULAR BIOLOGY (1985)
CHEN, ISY, STRUCTURE AND EXPRESSION OF C-REL, THE CELLULAR HOMOLOG TO THE ONCOGENE OF RETICULOENDOTHELIOSIS VIRUS STRAIN-T, JOURNAL OF VIROLOGY 45: 104 (1983). (10.1128/jvi.45.1.104-113.1983) / JOURNAL OF VIROLOGY (1983)
DELOTTO, R, A GENE REQUIRED FOR THE SPECIFICATION OF DORSAL-VENTRAL PATTERN IN DROSOPHILA APPEARS TO ENCODE A SERINE PROTEASE, NATURE 323: 688 (1986). (10.1038/323688a0) / NATURE (1986)
FREI, E, ISOLATION AND STRUCTURAL-ANALYSIS OF THE EXTRA SEX COMBS GENE OF DROSOPHILA, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 50: 127 (1985). (10.1101/SQB.1985.050.01.018) / COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (1985)
GILMORE, T.D., DIFFERENT LOCALIZATION OF THE PRODUCT OF THE V-REL ONCOGENE IN CHICKEN FIBROBLASTS AND SPLEEN-CELLS CORRELATES WITH TRANSFORMATION BY REV-T, CELL 44: 791 (1986). (10.1016/0092-8674(86)90845-7) / CELL (1986)
GILMORE T.D. COMMUNICATION.
GREENWALD, I, LIN-12, A NEMATODE HOMEOTIC GENE, IS HOMOLOGOUS TO A SET OF MAMMALIAN PROTEINS THAT INCLUDES EPIDERMAL GROWTH-FACTOR, CELL 43: 583 (1985). (10.1016/0092-8674(85)90230-2) / CELL (1985)
10.1126/science.2882603
10.1016/0378-1119(84)90153-7
INGHAM, P.W., TRANSCRIPTION PATTERN OF THE DROSOPHILA SEGMENTATION GENE HAIRY, NATURE 318: 439 (1985). (10.1038/318439a0) / NATURE (1985)
10.1126/science.2983426
MCGINNIS, W, A CONSERVED DNA-SEQUENCE IN HOMOEOTIC GENES OF THE DROSOPHILA ANTENNAPEDIA AND BITHORAX COMPLEXES, NATURE 308: 428 (1984). (10.1038/308428a0) / NATURE (1984)
Nusslein-Volhard, C., Determinants of Spatial Organization: 185 (1979). / Determinants of Spatial Organization (1979)
PADGETT, R.W., A TRANSCRIPT FROM A DROSOPHILA PATTERN GENE PREDICTS A PROTEIN HOMOLOGOUS TO THE TRANSFORMING GROWTH-FACTOR-BETA FAMILY, NATURE 325: 81 (1987). (10.1038/325081a0) / NATURE (1987)
POOLE, S.J., THE ENGRAILED LOCUS OF DROSOPHILA - STRUCTURAL-ANALYSIS OF AN EMBRYONIC TRANSCRIPT, CELL 40: 37 (1985). (10.1016/0092-8674(85)90306-X) / CELL (1985)
10.1016/0092-8674(87)90038-9
10.1073/pnas.74.12.5463
SANTAMARIA, P, PARTIAL RESCUE OF DORSAL, A MATERNAL EFFECT MUTATION AFFECTING THE DORSO-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO, BY THE INJECTION OF WILD-TYPE CYTOPLASM, EMBO JOURNAL 2: 1695 (1983). (10.1002/j.1460-2075.1983.tb01644.x) / EMBO JOURNAL (1983)
Stephens, R. M., Proceedings of the National Academy of Sciences of the United States of America 80: 6229 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
STEWARD, R, EXPRESSION OF THE DORSAL GENE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 50: 223 (1985). (10.1101/SQB.1985.050.01.028) / COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (1985)
Steward, R., Molecular Approacshes to Developmental Biology: 39 (1987). / Molecular Approacshes to Developmental Biology (1987)
STEWARD, R, ISOLATION OF THE DORSAL LOCUS OF DROSOPHILA, NATURE 311: 262 (1984). (10.1038/311262a0) / NATURE (1984)
SUMNERSMITH, M, CONSERVATION AND VARIABILITY OF WHEAT ALPHA-BETA-GLIADIN GENES, NUCLEIC ACIDS RESEARCH 13: 3905 (1985). (10.1093/nar/13.11.3905) / NUCLEIC ACIDS RESEARCH (1985)
10.1016/0092-8674(85)90308-3
WHARTON, K.A., NUCLEOTIDE-SEQUENCE FROM THE NEUROGENIC LOCUS NOTCH IMPLIES A GENE-PRODUCT THAT SHARES HOMOLOGY WITH PROTEINS CONTAINING EGF-LIKE REPEATS, CELL 43: 567 (1985). (10.1016/0092-8674(85)90229-6) / CELL (1985)
WILHELMSEN, K.C., NUCLEIC-ACID SEQUENCES OF THE ONCOGENE V-REL IN RETICULOENDOTHELIOSIS VIRUS STRAIN-T AND ITS CELLULAR HOMOLOG, THE PROTO-ONCOGENE C-REL, JOURNAL OF VIROLOGY 52: 172 (1984). (10.1128/jvi.52.1.172-182.1984) / JOURNAL OF VIROLOGY (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:36 p.m.)
Indexed	3 months ago (May 27, 2025, 4:46 a.m.)
Issued	37 years, 9 months ago (Oct. 30, 1987)
Published	37 years, 9 months ago (Oct. 30, 1987)
Published Print	37 years, 9 months ago (Oct. 30, 1987)

Funders 0

None

BibTeX

@article{Steward_1987, title={Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel}, volume={238}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3118464}, DOI={10.1126/science.3118464}, number={4827}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Steward, Ruth}, year={1987}, month=oct, pages={692–694} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        27
      ]
    ],
    "date-time": "2025-05-27T08:46:56Z",
    "timestamp": 1748335616261
  },
  "reference-count": 32,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4827",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1987,
        10,
        30
      ]
    ]
  },
  "abstract": "<jats:p>\n            The\n            <jats:italic>Drosophila</jats:italic>\n            gene,\n            <jats:italic>dorsal</jats:italic>\n            , is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The\n            <jats:italic>dorsal</jats:italic>\n            protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v-\n            <jats:italic>rel</jats:italic>\n            , its cellular homolog, c-\n            <jats:italic>rel</jats:italic>\n            , and a human c-\n            <jats:italic>rel</jats:italic>\n            fragment. The oncogene v-\n            <jats:italic>rel</jats:italic>\n            is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.\n          </jats:p>",
  "DOI": "10.1126/science.3118464",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T20:28:58Z",
    "timestamp": 1160080138000
  },
  "page": "692-694",
  "source": "Crossref",
  "is-referenced-by-count": 360,
  "title": "<i>Dorsal</i>\n            , an Embryonic Polarity Gene in\n            <i>Drosophila</i>\n            , Is Homologous to the Vertebrate Proto-Oncogene, c-\n            <i>rel</i>",
  "prefix": "10.1126",
  "volume": "238",
  "author": [
    {
      "given": "Ruth",
      "family": "Steward",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Biology, Princeton University, NJ 08544."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1016/0092-8674(85)90274-0",
      "volume": "42",
      "year": "1985",
      "unstructured": "ANDERSON, K.V., ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT, CELL 42: 779 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_2_1",
      "first-page": "177",
      "year": "1986",
      "unstructured": "Anderson, K. V., Gametogenesis and the Early Embryo: 177 (1986).",
      "journal-title": "Gametogenesis and the Early Embryo"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1038/311223a0",
      "volume": "311",
      "year": "1984",
      "unstructured": "ANDERSON, K.V., INFORMATION FOR THE DORSAL VENTRAL PATTERN OF THE DROSOPHILA EMBRYO IS STORED AS MATERNAL MESSENGER-RNA, NATURE 311: 223 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "269",
      "year": "1984",
      "unstructured": "Anderson, K. V., Primers in Developmental Biology: 269 (1984).",
      "journal-title": "Primers in Developmental Biology"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1016/0168-9525(87)90191-0",
      "volume": "3",
      "year": "1987",
      "unstructured": "ANDERSON, K.V., DORSAL VENTRAL EMBRYONIC PATTERN GENES OF DROSOPHILA, TRENDS IN GENETICS 3: 91 (1987).",
      "journal-title": "TRENDS IN GENETICS"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1016/0042-6822(81)90112-4",
      "volume": "115",
      "year": "1981",
      "unstructured": "BEUG, H, HEMATOPOIETIC-CELLS TRANSFORMED INVITRO BY REVT AVIAN RETICULOENDOTHELIOSIS VIRUS EXPRESS CHARACTERISTICS OF VERY IMMATURE LYMPHOID-CELLS, VIROLOGY 115: 295 (1981).",
      "journal-title": "VIROLOGY"
    },
    {
      "key": "e_1_2_1_7_1",
      "first-page": "2826",
      "volume": "5",
      "year": "1985",
      "unstructured": "BROWNELL, E, GENETIC-CHARACTERIZATION OF HUMAN C-REL SEQUENCES, MOLECULAR AND CELLULAR BIOLOGY 5: 2826 (1985).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "first-page": "104",
      "DOI": "10.1128/jvi.45.1.104-113.1983",
      "volume": "45",
      "year": "1983",
      "unstructured": "CHEN, ISY, STRUCTURE AND EXPRESSION OF C-REL, THE CELLULAR HOMOLOG TO THE ONCOGENE OF RETICULOENDOTHELIOSIS VIRUS STRAIN-T, JOURNAL OF VIROLOGY 45: 104 (1983).",
      "journal-title": "JOURNAL OF VIROLOGY"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "688",
      "DOI": "10.1038/323688a0",
      "volume": "323",
      "year": "1986",
      "unstructured": "DELOTTO, R, A GENE REQUIRED FOR THE SPECIFICATION OF DORSAL-VENTRAL PATTERN IN DROSOPHILA APPEARS TO ENCODE A SERINE PROTEASE, NATURE 323: 688 (1986).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1101/SQB.1985.050.01.018",
      "volume": "50",
      "year": "1985",
      "unstructured": "FREI, E, ISOLATION AND STRUCTURAL-ANALYSIS OF THE EXTRA SEX COMBS GENE OF DROSOPHILA, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 50: 127 (1985).",
      "journal-title": "COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1016/0092-8674(86)90845-7",
      "volume": "44",
      "year": "1986",
      "unstructured": "GILMORE, T.D., DIFFERENT LOCALIZATION OF THE PRODUCT OF THE V-REL ONCOGENE IN CHICKEN FIBROBLASTS AND SPLEEN-CELLS CORRELATES WITH TRANSFORMATION BY REV-T, CELL 44: 791 (1986).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_12_1",
      "unstructured": "GILMORE T.D. COMMUNICATION."
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "583",
      "DOI": "10.1016/0092-8674(85)90230-2",
      "volume": "43",
      "year": "1985",
      "unstructured": "GREENWALD, I, LIN-12, A NEMATODE HOMEOTIC GENE, IS HOMOLOGOUS TO A SET OF MAMMALIAN PROTEINS THAT INCLUDES EPIDERMAL GROWTH-FACTOR, CELL 43: 583 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2882603"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0378-1119(84)90153-7"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1038/318439a0",
      "volume": "318",
      "year": "1985",
      "unstructured": "INGHAM, P.W., TRANSCRIPTION PATTERN OF THE DROSOPHILA SEGMENTATION GENE HAIRY, NATURE 318: 439 (1985).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2983426"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "428",
      "DOI": "10.1038/308428a0",
      "volume": "308",
      "year": "1984",
      "unstructured": "MCGINNIS, W, A CONSERVED DNA-SEQUENCE IN HOMOEOTIC GENES OF THE DROSOPHILA ANTENNAPEDIA AND BITHORAX COMPLEXES, NATURE 308: 428 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_19_1",
      "first-page": "185",
      "year": "1979",
      "unstructured": "Nusslein-Volhard, C., Determinants of Spatial Organization: 185 (1979).",
      "journal-title": "Determinants of Spatial Organization"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1038/325081a0",
      "volume": "325",
      "year": "1987",
      "unstructured": "PADGETT, R.W., A TRANSCRIPT FROM A DROSOPHILA PATTERN GENE PREDICTS A PROTEIN HOMOLOGOUS TO THE TRANSFORMING GROWTH-FACTOR-BETA FAMILY, NATURE 325: 81 (1987).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1016/0092-8674(85)90306-X",
      "volume": "40",
      "year": "1985",
      "unstructured": "POOLE, S.J., THE ENGRAILED LOCUS OF DROSOPHILA - STRUCTURAL-ANALYSIS OF AN EMBRYONIC TRANSCRIPT, CELL 40: 37 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(87)90038-9"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.74.12.5463"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "1695",
      "DOI": "10.1002/j.1460-2075.1983.tb01644.x",
      "volume": "2",
      "year": "1983",
      "unstructured": "SANTAMARIA, P, PARTIAL RESCUE OF DORSAL, A MATERNAL EFFECT MUTATION AFFECTING THE DORSO-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO, BY THE INJECTION OF WILD-TYPE CYTOPLASM, EMBO JOURNAL 2: 1695 (1983).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_25_1",
      "first-page": "6229",
      "volume": "80",
      "year": "1983",
      "unstructured": "Stephens, R. M., Proceedings of the National Academy of Sciences of the United States of America 80: 6229 (1983).",
      "journal-title": "Proceedings of the National Academy of Sciences of the United States of America"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1101/SQB.1985.050.01.028",
      "volume": "50",
      "year": "1985",
      "unstructured": "STEWARD, R, EXPRESSION OF THE DORSAL GENE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 50: 223 (1985).",
      "journal-title": "COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"
    },
    {
      "key": "e_1_2_1_27_1",
      "first-page": "39",
      "year": "1987",
      "unstructured": "Steward, R., Molecular Approacshes to Developmental Biology: 39 (1987).",
      "journal-title": "Molecular Approacshes to Developmental Biology"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "crossref",
      "first-page": "262",
      "DOI": "10.1038/311262a0",
      "volume": "311",
      "year": "1984",
      "unstructured": "STEWARD, R, ISOLATION OF THE DORSAL LOCUS OF DROSOPHILA, NATURE 311: 262 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "crossref",
      "first-page": "3905",
      "DOI": "10.1093/nar/13.11.3905",
      "volume": "13",
      "year": "1985",
      "unstructured": "SUMNERSMITH, M, CONSERVATION AND VARIABILITY OF WHEAT ALPHA-BETA-GLIADIN GENES, NUCLEIC ACIDS RESEARCH 13: 3905 (1985).",
      "journal-title": "NUCLEIC ACIDS RESEARCH"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(85)90308-3"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1016/0092-8674(85)90229-6",
      "volume": "43",
      "year": "1985",
      "unstructured": "WHARTON, K.A., NUCLEOTIDE-SEQUENCE FROM THE NEUROGENIC LOCUS NOTCH IMPLIES A GENE-PRODUCT THAT SHARES HOMOLOGY WITH PROTEINS CONTAINING EGF-LIKE REPEATS, CELL 43: 567 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "crossref",
      "first-page": "172",
      "DOI": "10.1128/jvi.52.1.172-182.1984",
      "volume": "52",
      "year": "1984",
      "unstructured": "WILHELMSEN, K.C., NUCLEIC-ACID SEQUENCES OF THE ONCOGENE V-REL IN RETICULOENDOTHELIOSIS VIRUS STRAIN-T AND ITS CELLULAR HOMOLOG, THE PROTO-ONCOGENE C-REL, JOURNAL OF VIROLOGY 52: 172 (1984).",
      "journal-title": "JOURNAL OF VIROLOGY"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.3118464",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T21:36:36Z",
    "timestamp": 1705181796000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.3118464"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1987,
        10,
        30
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "4827",
    "published-print": {
      "date-parts": [
        [
          1987,
          10,
          30
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3118464"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3118464",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1987,
        10,
        30
      ]
    ]
  }
}