DOI: 10.1126/science.308697. Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble Partial Denervation in Changing Synaptic Organization

Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble Partial Denervation in Changing Synaptic Organization

10.1126/science.308697

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.

Bibliography

Roper, S., & Ko, C.-P. (1978). Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble Partial Denervation in Changing Synaptic Organization. Science, 202(4363), 66â68.

Authors 2

S. Roper (first)
C.-P. Ko (additional)

References 20 Referenced 10

BARKER, D, SPROUTING AND DEGENERATION OF MAMMALIAN MOTOR AXONS IN NORMAL AND DE-AFFERENTATED SKELETAL MUSCLE, PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES 163: 538 (1966). / PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES (1966)
BROWN, M.C., MOTOR NEURON SPROUTING INDUCED BY PROLONGED TETRODOTOXIN BLOCK OF NERVE ACTION POTENTIALS, NATURE 265: 459 (1977). (10.1038/265459a0) / NATURE (1977)
COURTNEY, K, SPROUTING OF SYNAPSES AFTER PARTIAL DENERVATION OF FROG CARDIAC GANGLION, NATURE 259: 317 (1976). (10.1038/259317a0) / NATURE (1976)
DENNIS, M.J., SYNAPTIC TRANSMISSION AND ITS DUPLICATION BY FOCALLY APPLIED ACETYLCHOLINE IN PARASYMPATHETIC NEURONS IN HEART OF FROG, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 177: 509 (1971). / PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES (1971)
10.1126/science.935873
LAVOIE, P.A., COMPARISON OF ALPHA-BUNGAROTOXIN BINDING TO SKELETAL-MUSCLES AFTER INACTIVITY OR DENERVATION, NATURE 260: 349 (1976). (10.1038/260349a0) / NATURE (1976)
LOMO, T, CONTROL OF ACH SENSITIVITY BY MUSCLE ACTIVITY IN RAT, JOURNAL OF PHYSIOLOGY-LONDON 221: 493 (1972). (10.1113/jphysiol.1972.sp009764) / JOURNAL OF PHYSIOLOGY-LONDON (1972)
LYNCH, G, INDUCED ACETYLCHOLINESTERASE-RICH LAYER IN RAT DENTATE GYRUS FOLLOWING ENTORHINAL LESIONS, BRAIN RESEARCH 42: 311 (1972). (10.1016/0006-8993(72)90533-1) / BRAIN RESEARCH (1972)
10.1126/science.180.4093.1364
MCMAHAN, U.J., VISUAL IDENTIFICATION OF SYNAPTIC BOUTONS ON LIVING GANGLION CELLS AND OF VARICOSITIES IN POSTGANGLIONIC AXONS IN HEART OF FROG, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 177: 485 (1971). / PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES (1971)
MURAKAMI, F, PHYSIOLOGICAL PROPERTIES OF NEWLY FORMED CORTICO-RUBRAL SYNAPSES OF RED NUCLEUS NEURONS DUE TO COLLATERAL SPROUTING, BRAIN RESEARCH 103: 147 (1976). (10.1016/0006-8993(76)90696-X) / BRAIN RESEARCH (1976)
MURRAY, J.G., THE OCCURRENCE AND FUNCTION OF COLLATERAL SPROUTING IN THE SYMPATHETIC NERVOUS SYSTEM OF THE CAT, JOURNAL OF PHYSIOLOGY-LONDON 135: 133 (1957). (10.1113/jphysiol.1957.sp005700) / JOURNAL OF PHYSIOLOGY-LONDON (1957)
NAKAMURA, Y, SYNAPTIC REORGANIZATION OF RED NUCLEUS AFTER CHRONIC DEAFFERENTATION FROM CEREBELLORUBRAL FIBERS - ELECTRON-MICROSCOPE STUDY IN CAT, BRAIN RESEARCH 82: 298 (1974). (10.1016/0006-8993(74)90609-X) / BRAIN RESEARCH (1974)
PESTRONK, A, EFFECT OF MUSCLE DISUSE ON ACETYLCHOLINE RECEPTORS, NATURE 260: 352 (1976). (10.1038/260352a0) / NATURE (1976)
RAISMAN, G, QUANTITATIVE INVESTIGATION OF DEVELOPMENT OF COLLATERAL REINNERVATION AFTER PARTIAL DEAFFERENTATION OF SEPTAL NUCLEI, BRAIN RESEARCH 50: 241 (1973). (10.1016/0006-8993(73)90729-4) / BRAIN RESEARCH (1973)
RAMONYCAJAL S DEGENERATION REGENER (1928).
ROBERT, E.D., ABSENCE OF SUPERSENSITIVITY TO ACETYLCHOLINE IN INNERVATED MUSCLE SUBJECTED TO A PROLONGED PHARMACOLOGIC NERVE BLOCK, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 174: 133 (1970). / JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1970)
ROPER, S, SPROUTING AND REGENERATION OF SYNAPTIC TERMINALS IN FROG CARDIAC GANGLION, NATURE 261: 148 (1976). (10.1038/261148a0) / NATURE (1976)
SOTELO, C, ALTERED AXONS AND AXON TERMINALS IN LATERAL VESTIBULAR NUCLEUS OF RAT - POSSIBLE EXAMPLE OF AXONAL REMODELING, LABORATORY INVESTIGATION 25: 653 (1971). / LABORATORY INVESTIGATION (1971)
TUFFERY, A.R., GROWTH AND DEGENERATION OF MOTOR END-PLATES IN NORMAL CAT HIND LIMB MUSCLES, JOURNAL OF ANATOMY 110: 221 (1971). / JOURNAL OF ANATOMY (1971)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:35 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:38 p.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 5:21 p.m.)
Issued	46 years, 10 months ago (Oct. 6, 1978)
Published	46 years, 10 months ago (Oct. 6, 1978)
Published Print	46 years, 10 months ago (Oct. 6, 1978)

Funders 0

None

BibTeX

@article{Roper_1978, title={Impulse Blockade in Frog Cardiac Ganglion Does Not Resemble Partial Denervation in Changing Synaptic Organization}, volume={202}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.308697}, DOI={10.1126/science.308697}, number={4363}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Roper, S. and Ko, C.-P.}, year={1978}, month=oct, pages={66–68} }

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