DOI: 10.1126/science.3080807. Detection of α-Transducin in Retinal Rods But Not Cones

Detection of α-Transducin in Retinal Rods But Not Cones

10.1126/science.3080807

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The distribution in chicken retina of the α subunit of transducin, the guanine nucleotide-binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3′,5′-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. α-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to α-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

Bibliography

Grunwald, G. B., Gierschik, P., Nirenberg, M., & Spiegel, A. (1986). Detection of Î±-Transducin in Retinal Rods But Not Cones. Science, 231(4740), 856â859.

Authors 4

Gerald B. Grunwald (first)
Peter Gierschik (additional)
Marshall Nirenberg (additional)
Allen Spiegel (additional)

References 29 Referenced 41

ATWELL, D, NATURE 317: 14 (1985). (10.1038/317014a0) / NATURE (1985)
BAYLOR, D.A., RESPONSES OF RETINAL RODS TO SINGLE PHOTONS, JOURNAL OF PHYSIOLOGY-LONDON 288: 613 (1979). (10.1113/jphysiol.1979.sp012716) / JOURNAL OF PHYSIOLOGY-LONDON (1979)
BERGER, S.J., THE DISTRIBUTION OF THE COMPONENTS OF THE CYCLIC-GMP CYCLE IN RETINA, JOURNAL OF BIOLOGICAL CHEMISTRY 255: 3128 (1980). (10.1016/S0021-9258(19)85861-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1980)
COBBS, W.H., CYCLIC-GMP INCREASES PHOTOCURRENT AND LIGHT SENSITIVITY OF RETINAL CONES, NATURE 317: 64 (1985). (10.1038/317064a0) / NATURE (1985)
FARBER, D.B., CYCLIC-NUCLEOTIDES OF CONE-DOMINANT RETINAS - REDUCTION OF CYCLIC-AMP LEVELS BY LIGHT AND BY CONE DEGENERATION, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 20: 24 (1981). / INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (1981)
FARBER, D.B., CGMP-PHOSPHODIESTERASE OF RETINAL PHOTORECEPTORS - SPECIFIC LOCALIZATION IN RODS DEMONSTRATED BY IMMUNOCYTOCHEMISTRY, JOURNAL OF CELL BIOLOGY 99: A64 (1984). / JOURNAL OF CELL BIOLOGY (1984)
Fung, B. K., Proceedings of the National Academy of Sciences of the United States of America 78: 152 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
FUORTES, M.G., HDB SENSORY PHYSL 7: 321 (1972). / HDB SENSORY PHYSL (1972)
GIERSCHIK, P, ANTISERA AGAINST A GUANINE-NUCLEOTIDE BINDING-PROTEIN FROM RETINA CROSS-REACT WITH THE BETA-SUBUNIT OF THE ADENYLYL CYCLASE-ASSOCIATED GUANINE-NUCLEOTIDE BINDING-PROTEINS, NS AND NI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 727 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
GRUNWALD, G.B., MONOCLONAL-ANTIBODY 18B8 DETECTS GANGLIOSIDES ASSOCIATED WITH NEURONAL DIFFERENTIATION AND SYNAPSE FORMATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4008 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
HAYNES, L, CYCLIC GMP-SENSITIVE CONDUCTANCE IN OUTER SEGMENT MEMBRANE OF CATFISH CONES, NATURE 317: 61 (1985). (10.1038/317061a0) / NATURE (1985)
Hurley, J. B., Proceedings of the National Academy of Sciences of the United States of America 81: 6948 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
HURWITZ, R.L., IMMUNOLOGICAL CHARACTERIZATION OF THE PHOTORECEPTOR OUTER SEGMENT CYCLIC-GMP PHOSPHODIESTERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 8612 (1984). (10.1016/S0021-9258(17)39774-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1984)
10.1126/science.3856323
MANNING, D.R., THE REGULATORY COMPONENTS OF ADENYLATE-CYCLASE AND TRANSDUCIN - A FAMILY OF STRUCTURALLY HOMOLOGOUS GUANINE NUCLEOTIDE-BINDING PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 258: 7059 (1983). (10.1016/S0021-9258(18)32332-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1983)
MEDYNSKI, D.C., AMINO-ACID SEQUENCE OF THE ALPHA-SUBUNIT OF TRANSDUCIN DEDUCED FROM THE CDNA SEQUENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4311 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
MELLER, K, THE ULTRASTRUCTURE OF THE DEVELOPING INNER AND OUTER SEGMENTS OF THE PHOTORECEPTORS OF CHICK-EMBRYO RETINA AS REVEALED BY THE RAPID-FREEZING AND DEEP-ETCHING TECHNIQUES, ANATOMY AND EMBRYOLOGY 169: 141 (1984). (10.1007/BF00303143) / ANATOMY AND EMBRYOLOGY (1984)
MORRIS, V.B., SYMMETRY IN A RECEPTOR MOSAIC DEMONSTRATED IN CHICK FROM FREQUENCIES, SPACING AND ARRANGEMENT OF TYPES OF RETINAL RECEPTOR, JOURNAL OF COMPARATIVE NEUROLOGY 140: 359 (1970). (10.1002/cne.901400308) / JOURNAL OF COMPARATIVE NEUROLOGY (1970)
Nathans, J., Proceedings of the National Academy of Sciences of the United States of America 81: 4851 (1984). / Proceedings of the National Academy of Sciences of the United States of America (1984)
Nathans J. unpublished results.
OLSEN, M.D., ANAT REC 193: 423 (1979). (10.1002/ar.1091930308) / ANAT REC (1979)
ORTEZ, R.A., DETECTION OF A LIGHT-SENSITIVE POOL OF CGMP IN GOLDFISH CONE COLOR RECEPTORS BY IMMUNOCYTOCHEMISTRY, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 31: 1305 (1983). (10.1177/31.11.6311894) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1983)
PINES, M, ANTIBODIES AGAINST THE CARBOXYL-TERMINAL 5-KDA PEPTIDE OF THE ALPHA-SUBUNIT OF TRANSDUCIN CROSSREACT WITH THE 40-KDA BUT NOT THE 39-KDA GUANINE-NUCLEOTIDE BINDING-PROTEIN FROM BRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4095 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
POBER, J.S., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 11: 265 (1979). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1979)
SCHWARTZ, E.A., PHOTOTRANSDUCTION IN VERTEBRATE RODS, ANNUAL REVIEW OF NEUROSCIENCE 8: 339 (1985). (10.1146/annurev.ne.08.030185.002011) / ANNUAL REVIEW OF NEUROSCIENCE (1985)
STRYER, L, LIGHT-ACTIVATED RETINAL PROTEINS, NATURE 312: 498 (1984). (10.1038/312498a0) / NATURE (1984)
TANABE, T, PRIMARY STRUCTURE OF THE ALPHA-SUBUNIT OF TRANSDUCIN AND ITS RELATIONSHIP TO RAS PROTEINS, NATURE 315: 242 (1985). (10.1038/315242a0) / NATURE (1985)
WITKOVSKY, P, AN ONTOGENETIC STUDY OF RETINAL FUNCTION IN THE CHICK, VISION RESEARCH 3: 341 (1963). (10.1016/0042-6989(63)90008-7) / VISION RESEARCH (1963)
YATSUNAMI, K, GTPASE OF BOVINE ROD OUTER SEGMENTS - THE AMINO-ACID SEQUENCE OF THE ALPHA-SUBUNIT AS DERIVED FROM THE CDNA SEQUENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4316 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:17 p.m.)
Indexed	1 year ago (Sept. 2, 2024, 5:13 a.m.)
Issued	39 years, 6 months ago (Feb. 21, 1986)
Published	39 years, 6 months ago (Feb. 21, 1986)
Published Print	39 years, 6 months ago (Feb. 21, 1986)

Funders 0

None

BibTeX

@article{Grunwald_1986, title={Detection of α-Transducin in Retinal Rods But Not Cones}, volume={231}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3080807}, DOI={10.1126/science.3080807}, number={4740}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Grunwald, Gerald B. and Gierschik, Peter and Nirenberg, Marshall and Spiegel, Allen}, year={1986}, month=feb, pages={856–859} }

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