DOI: 10.1126/science.3037705. Identification of a Family of Muscarinic Acetylcholine Receptor Genes

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

10.1126/science.3037705

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.

Bibliography

Bonner, T. I., Buckley, N. J., Young, A. C., & Brann, M. R. (1987). Identification of a Family of Muscarinic Acetylcholine Receptor Genes. Science, 237(4814), 527â532.

Authors 4

T. I. Bonner (first)
N. J. Buckley (additional)
A. C. Young (additional)
M. R. Brann (additional)

References 32 Referenced 1,174

Bonner, T. I., Molecular Brain Research 2: 243 (1987). (10.1016/0169-328X(87)90031-3) / Molecular Brain Research (1987)
BONNER T.I. unpublished data.
Brann, M. R., Molecular Pharmacology 32: 450 (1987). / Molecular Pharmacology (1987)
CHUNG, F.Z., CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN-BRAIN BETA-ADRENERGIC-RECEPTOR - EVOLUTIONARY RELATIONSHIP TO RODENT AND AVIAN BETA-RECEPTORS AND PORCINE MUSCARINIC RECEPTORS, FEBS LETTERS 211: 200 (1987). (10.1016/0014-5793(87)81436-9) / FEBS LETTERS (1987)
Dayhoff, M. O., Atlas of Protein Sequence and Structure 5 3: 345 (1978). / Atlas of Protein Sequence and Structure (1978)
10.1038/321075a0
10.1038/326073a0
EVANS, T, MOLECULAR PHARMACOLOGY 26: 395 (1984). / MOLECULAR PHARMACOLOGY (1984)
EVANS, T, GUANINE NUCLEOTIDE-SENSITIVE, HIGH-AFFINITY BINDING OF CARBACHOL TO MUSCARINIC CHOLINERGIC RECEPTORS OF 1321N1 ASTROCYTOMA-CELLS IS INSENSITIVE TO PERTUSSIS TOXIN, MOLECULAR PHARMACOLOGY 27: 32 (1985). / MOLECULAR PHARMACOLOGY (1985)
GILBERT, W, ON THE ANTIQUITY OF INTRONS, CELL 46: 151 (1986). (10.1016/0092-8674(86)90730-0) / CELL (1986)
GILBERT, W, WHY GENES IN PIECES, NATURE 271: 501 (1978). (10.1038/271501a0) / NATURE (1978)
GILMAN, A.G., G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE, CELL 36: 577 (1984). (10.1016/0092-8674(84)90336-2) / CELL (1984)
10.1016/0042-6822(73)90341-3
HAMMER, R, PIRENZEPINE DISTINGUISHES BETWEEN DIFFERENT SUBCLASSES OF MUSCARINIC RECEPTORS, NATURE 283: 90 (1980). (10.1038/283090a0) / NATURE (1980)
HARDEN, T.K., TRENDS IN PHARMACOLOGICAL SCIENCES 7 Supplement: 14 (1986). (10.1016/0165-6147(86)90232-4) / TRENDS IN PHARMACOLOGICAL SCIENCES (1986)
KOBILKA, B.K., CDNA FOR THE HUMAN BETA-2-ADRENERGIC RECEPTOR - A PROTEIN WITH MULTIPLE MEMBRANE-SPANNING DOMAINS AND ENCODED BY A GENE WHOSE CHROMOSOMAL LOCATION IS SHARED WITH THAT OF THE RECEPTOR FOR PLATELET-DERIVED GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 46 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
KUBO, T, PRIMARY STRUCTURE OF PORCINE CARDIAC MUSCARINIC ACETYLCHOLINE-RECEPTOR DEDUCED FROM THE CDNA SEQUENCE, FEBS LETTERS 209: 367 (1986). (10.1016/0014-5793(86)81144-9) / FEBS LETTERS (1986)
KUBO, T, CLONING, SEQUENCING AND EXPRESSION OF COMPLEMENTARY-DNA ENCODING THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, NATURE 323: 411 (1986). (10.1038/323411a0) / NATURE (1986)
LAWN, R.M., ISOLATION AND CHARACTERIZATION OF LINKED DELTA-GLOBIN AND BETA-GLOBIN GENES FROM A CLONED LIBRARY OF HUMAN DNA, CELL 15: 1157 (1978). (10.1016/0092-8674(78)90043-0) / CELL (1978)
MISHINA, M, EXPRESSION OF FUNCTIONAL ACETYLCHOLINE-RECEPTOR FROM CLONED CDNAS, NATURE 307: 604 (1984). (10.1038/307604a0) / NATURE (1984)
MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982). (10.1093/nar/10.2.459) / NUCLEIC ACIDS RESEARCH (1982)
NATHANS, J, ISOLATION, SEQUENCE-ANALYSIS, AND INTRON EXON ARRANGEMENT OF THE GENE ENCODING BOVINE RHODOPSIN, CELL 34: 807 (1983). (10.1016/0092-8674(83)90537-8) / CELL (1983)
10.1126/science.2937147
NATHANSON, N.M., MOLECULAR-PROPERTIES OF THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, ANNUAL REVIEW OF NEUROSCIENCE 10: 195 (1987). (10.1146/annurev.ne.10.030187.001211) / ANNUAL REVIEW OF NEUROSCIENCE (1987)
OKAYAMA, H, A CDNA CLONING VECTOR THAT PERMITS EXPRESSION OF CDNA INSERTS IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 3: 280 (1983). / MOLECULAR AND CELLULAR BIOLOGY (1983)
OVCHINNIKOV, Y.A., RHODOPSIN AND BACTERIORHODOPSIN - STRUCTURE-FUNCTION-RELATIONSHIPS, FEBS LETTERS 148: 179 (1982). (10.1016/0014-5793(82)80805-3) / FEBS LETTERS (1982)
10.1126/science.3107123
SARGENT, T.D., RAT SERUM-ALBUMIN GENE - ANALYSIS OF CLONED SEQUENCES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3256 (1979). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1979)
SPIEGEL, A.M., SIGNAL TRANSDUCTION BY GUANINE-NUCLEOTIDE BINDING-PROTEINS, MOLECULAR AND CELLULAR ENDOCRINOLOGY 49: 1 (1987). (10.1016/0303-7207(87)90058-X) / MOLECULAR AND CELLULAR ENDOCRINOLOGY (1987)
STRYER, L, ANNUAL REVIEW OF CELL BIOLOGY 2: 391 (1986). (10.1146/annurev.cb.02.110186.002135) / ANNUAL REVIEW OF CELL BIOLOGY (1986)
YARDEN, Y, THE AVIAN BETA-ADRENERGIC-RECEPTOR - PRIMARY STRUCTURE AND MEMBRANE TOPOLOGY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6795 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
YOUNG, W.S., MESENCEPHALIC DOPAMINE NEURONS REGULATE THE EXPRESSION OF NEUROPEPTIDE MESSENGER-RNAS IN THE RAT FOREBRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 9827 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:28 a.m.)
Indexed	2 days, 4 hours ago (Sept. 4, 2025, 9:49 a.m.)
Issued	38 years, 1 month ago (July 31, 1987)
Published	38 years, 1 month ago (July 31, 1987)
Published Print	38 years, 1 month ago (July 31, 1987)

Funders 0

None

BibTeX

@article{Bonner_1987, title={Identification of a Family of Muscarinic Acetylcholine Receptor Genes}, volume={237}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3037705}, DOI={10.1126/science.3037705}, number={4814}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bonner, T. I. and Buckley, N. J. and Young, A. C. and Brann, M. R.}, year={1987}, month=jul, pages={527–532} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:49:27Z",
    "timestamp": 1756993767791
  },
  "reference-count": 32,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4814",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1987,
        7,
        31
      ]
    ]
  },
  "abstract": "<jats:p>Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.</jats:p>",
  "DOI": "10.1126/science.3037705",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T20:28:58Z",
    "timestamp": 1160080138000
  },
  "page": "527-532",
  "source": "Crossref",
  "is-referenced-by-count": 1174,
  "title": "Identification of a Family of Muscarinic Acetylcholine Receptor Genes",
  "prefix": "10.1126",
  "volume": "237",
  "author": [
    {
      "given": "T. I.",
      "family": "Bonner",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892."
        }
      ]
    },
    {
      "given": "N. J.",
      "family": "Buckley",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892."
        }
      ]
    },
    {
      "given": "A. C.",
      "family": "Young",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892."
        }
      ]
    },
    {
      "given": "M. R.",
      "family": "Brann",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/0169-328X(87)90031-3",
      "volume": "2",
      "year": "1987",
      "unstructured": "Bonner, T. I., Molecular Brain Research 2: 243 (1987).",
      "journal-title": "Molecular Brain Research"
    },
    {
      "key": "e_1_2_1_2_1",
      "unstructured": "BONNER T.I. unpublished data."
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "450",
      "volume": "32",
      "year": "1987",
      "unstructured": "Brann, M. R., Molecular Pharmacology 32: 450 (1987).",
      "journal-title": "Molecular Pharmacology"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1016/0014-5793(87)81436-9",
      "volume": "211",
      "year": "1987",
      "unstructured": "CHUNG, F.Z., CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN-BRAIN BETA-ADRENERGIC-RECEPTOR - EVOLUTIONARY RELATIONSHIP TO RODENT AND AVIAN BETA-RECEPTORS AND PORCINE MUSCARINIC RECEPTORS, FEBS LETTERS 211: 200 (1987).",
      "journal-title": "FEBS LETTERS"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "345",
      "volume": "5",
      "year": "1978",
      "unstructured": "Dayhoff, M. O., Atlas of Protein Sequence and Structure 5 3: 345 (1978).",
      "journal-title": "Atlas of Protein Sequence and Structure"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/321075a0"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326073a0"
    },
    {
      "key": "e_1_2_1_8_1",
      "first-page": "395",
      "volume": "26",
      "year": "1984",
      "unstructured": "EVANS, T, MOLECULAR PHARMACOLOGY 26: 395 (1984).",
      "journal-title": "MOLECULAR PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_9_1",
      "first-page": "32",
      "volume": "27",
      "year": "1985",
      "unstructured": "EVANS, T, GUANINE NUCLEOTIDE-SENSITIVE, HIGH-AFFINITY BINDING OF CARBACHOL TO MUSCARINIC CHOLINERGIC RECEPTORS OF 1321N1 ASTROCYTOMA-CELLS IS INSENSITIVE TO PERTUSSIS TOXIN, MOLECULAR PHARMACOLOGY 27: 32 (1985).",
      "journal-title": "MOLECULAR PHARMACOLOGY"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/0092-8674(86)90730-0",
      "volume": "46",
      "year": "1986",
      "unstructured": "GILBERT, W, ON THE ANTIQUITY OF INTRONS, CELL 46: 151 (1986).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1038/271501a0",
      "volume": "271",
      "year": "1978",
      "unstructured": "GILBERT, W, WHY GENES IN PIECES, NATURE 271: 501 (1978).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1016/0092-8674(84)90336-2",
      "volume": "36",
      "year": "1984",
      "unstructured": "GILMAN, A.G., G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE, CELL 36: 577 (1984).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0042-6822(73)90341-3"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1038/283090a0",
      "volume": "283",
      "year": "1980",
      "unstructured": "HAMMER, R, PIRENZEPINE DISTINGUISHES BETWEEN DIFFERENT SUBCLASSES OF MUSCARINIC RECEPTORS, NATURE 283: 90 (1980).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "crossref",
      "first-page": "14",
      "DOI": "10.1016/0165-6147(86)90232-4",
      "volume": "7",
      "year": "1986",
      "unstructured": "HARDEN, T.K., TRENDS IN PHARMACOLOGICAL SCIENCES 7 Supplement: 14 (1986).",
      "journal-title": "TRENDS IN PHARMACOLOGICAL SCIENCES"
    },
    {
      "key": "e_1_2_1_16_1",
      "first-page": "46",
      "volume": "84",
      "year": "1987",
      "unstructured": "KOBILKA, B.K., CDNA FOR THE HUMAN BETA-2-ADRENERGIC RECEPTOR - A PROTEIN WITH MULTIPLE MEMBRANE-SPANNING DOMAINS AND ENCODED BY A GENE WHOSE CHROMOSOMAL LOCATION IS SHARED WITH THAT OF THE RECEPTOR FOR PLATELET-DERIVED GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 46 (1987).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "367",
      "DOI": "10.1016/0014-5793(86)81144-9",
      "volume": "209",
      "year": "1986",
      "unstructured": "KUBO, T, PRIMARY STRUCTURE OF PORCINE CARDIAC MUSCARINIC ACETYLCHOLINE-RECEPTOR DEDUCED FROM THE CDNA SEQUENCE, FEBS LETTERS 209: 367 (1986).",
      "journal-title": "FEBS LETTERS"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1038/323411a0",
      "volume": "323",
      "year": "1986",
      "unstructured": "KUBO, T, CLONING, SEQUENCING AND EXPRESSION OF COMPLEMENTARY-DNA ENCODING THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, NATURE 323: 411 (1986).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1016/0092-8674(78)90043-0",
      "volume": "15",
      "year": "1978",
      "unstructured": "LAWN, R.M., ISOLATION AND CHARACTERIZATION OF LINKED DELTA-GLOBIN AND BETA-GLOBIN GENES FROM A CLONED LIBRARY OF HUMAN DNA, CELL 15: 1157 (1978).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "604",
      "DOI": "10.1038/307604a0",
      "volume": "307",
      "year": "1984",
      "unstructured": "MISHINA, M, EXPRESSION OF FUNCTIONAL ACETYLCHOLINE-RECEPTOR FROM CLONED CDNAS, NATURE 307: 604 (1984).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "459",
      "DOI": "10.1093/nar/10.2.459",
      "volume": "10",
      "year": "1982",
      "unstructured": "MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982).",
      "journal-title": "NUCLEIC ACIDS RESEARCH"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1016/0092-8674(83)90537-8",
      "volume": "34",
      "year": "1983",
      "unstructured": "NATHANS, J, ISOLATION, SEQUENCE-ANALYSIS, AND INTRON EXON ARRANGEMENT OF THE GENE ENCODING BOVINE RHODOPSIN, CELL 34: 807 (1983).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2937147"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1146/annurev.ne.10.030187.001211",
      "volume": "10",
      "year": "1987",
      "unstructured": "NATHANSON, N.M., MOLECULAR-PROPERTIES OF THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, ANNUAL REVIEW OF NEUROSCIENCE 10: 195 (1987).",
      "journal-title": "ANNUAL REVIEW OF NEUROSCIENCE"
    },
    {
      "key": "e_1_2_1_25_1",
      "first-page": "280",
      "volume": "3",
      "year": "1983",
      "unstructured": "OKAYAMA, H, A CDNA CLONING VECTOR THAT PERMITS EXPRESSION OF CDNA INSERTS IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 3: 280 (1983).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/0014-5793(82)80805-3",
      "volume": "148",
      "year": "1982",
      "unstructured": "OVCHINNIKOV, Y.A., RHODOPSIN AND BACTERIORHODOPSIN - STRUCTURE-FUNCTION-RELATIONSHIPS, FEBS LETTERS 148: 179 (1982).",
      "journal-title": "FEBS LETTERS"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3107123"
    },
    {
      "key": "e_1_2_1_28_1",
      "first-page": "3256",
      "volume": "76",
      "year": "1979",
      "unstructured": "SARGENT, T.D., RAT SERUM-ALBUMIN GENE - ANALYSIS OF CLONED SEQUENCES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3256 (1979).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0303-7207(87)90058-X",
      "volume": "49",
      "year": "1987",
      "unstructured": "SPIEGEL, A.M., SIGNAL TRANSDUCTION BY GUANINE-NUCLEOTIDE BINDING-PROTEINS, MOLECULAR AND CELLULAR ENDOCRINOLOGY 49: 1 (1987).",
      "journal-title": "MOLECULAR AND CELLULAR ENDOCRINOLOGY"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1146/annurev.cb.02.110186.002135",
      "volume": "2",
      "year": "1986",
      "unstructured": "STRYER, L, ANNUAL REVIEW OF CELL BIOLOGY 2: 391 (1986).",
      "journal-title": "ANNUAL REVIEW OF CELL BIOLOGY"
    },
    {
      "key": "e_1_2_1_31_1",
      "first-page": "6795",
      "volume": "83",
      "year": "1986",
      "unstructured": "YARDEN, Y, THE AVIAN BETA-ADRENERGIC-RECEPTOR - PRIMARY STRUCTURE AND MEMBRANE TOPOLOGY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6795 (1986).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_32_1",
      "first-page": "9827",
      "volume": "83",
      "year": "1986",
      "unstructured": "YOUNG, W.S., MESENCEPHALIC DOPAMINE NEURONS REGULATE THE EXPRESSION OF NEUROPEPTIDE MESSENGER-RNAS IN THE RAT FOREBRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 9827 (1986).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.3037705",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T15:28:15Z",
    "timestamp": 1705159695000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.3037705"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1987,
        7,
        31
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "4814",
    "published-print": {
      "date-parts": [
        [
          1987,
          7,
          31
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.3037705"
  ],
  "URL": "http://dx.doi.org/10.1126/science.3037705",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1987,
        7,
        31
      ]
    ]
  }
}