A Physiological Basis for a Theory of Synapse Modification
10.1126/science.3037696
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The functional organization of the cerebral cortex is modified dramatically by sensory experience during early postnatal life. The basis for these modifications is a type of synaptic plasticity that may also contribute to some forms of adult learning. The question of how synapses modify according to experience has been approached by determining theoretically what is required of a modification mechanism to account for the available experimental data in the developing visual cortex. The resulting theory states precisely how certain variables might influence synaptic modifications. This insight has led to the development of a biologically plausible molecular model for synapse modification in the cerebral cortex.

Bibliography

Bear, M. F., Cooper, L. N., & Ebner, F. F. (1987). A Physiological Basis for a Theory of Synapse Modification. Science, 237(4810), 42–48.

Authors 3
  1. Mark F. Bear (first)
  2. Leon N. Cooper (additional)
  3. Ford F. Ebner (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 10:28 a.m.)
Indexed 3 weeks, 5 days ago (July 28, 2025, 5:41 p.m.)
Issued 38 years, 1 month ago (July 3, 1987)
Published 38 years, 1 month ago (July 3, 1987)
Published Print 38 years, 1 month ago (July 3, 1987)
Funders 0

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@article{Bear_1987, title={A Physiological Basis for a Theory of Synapse Modification}, volume={237}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3037696}, DOI={10.1126/science.3037696}, number={4810}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bear, Mark F. and Cooper, Leon N. and Ebner, Ford F.}, year={1987}, month=jul, pages={42–48} }