DOI: 10.1126/science.3020691. Genomic Analysis of the Human B-Lymphotropic Virus (HBLV)

Genomic Analysis of the Human B-Lymphotropic Virus (HBLV)

10.1126/science.3020691

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The human B-lymphotropic virus (HBLV) has a double-stranded DNA genome of greater than 110 kilobase pairs, which is consistent with its morphological classification as a herpesvirus. A 9000-base pair cloned probe of HBLV detected specific sequences in DNA and RNA of infected cells but did not hybridize to the genomic DNA of other human herpesviruses including the Epstein-Barr virus, human cytomegalovirus, herpes simplex type I, and varicella-zoster virus. Conversely, while probes obtained from each of the known human herpesvirus readily detected the homologous viral DNA, they did not hybridize to genomic HBLV DNA. This evidence, in addition to serological and morphological distinctions and the biological effects of this virus demonstrate that HBLV is a novel human herpesvirus.

Bibliography

Josephs, S. F., Salahuddin, S. Z., Ablashi, D. V., Schachter, F., Wong-Staal, F., & Gallo, R. C. (1986). Genomic Analysis of the Human B-Lymphotropic Virus (HBLV). Science, 234(4776), 601â603.

Authors 6

Steven F. Josephs (first)
S. Zaki Salahuddin (additional)
Dharam V. Ablashi (additional)
Francois Schachter (additional)
Flossie Wong-Staal (additional)
Robert C. Gallo (additional)

References 13 Referenced 183

ALFORD, C.A., VIROLOGY: 629 (1985). / VIROLOGY (1985)
BERENT, S.L., BIOTECHNIQUES 3: 208 (1985). / BIOTECHNIQUES (1985)
BORNKAMM, G.W., STRUCTURE OF HERPESVIRUS-SAIMIRI GENOMES - ARRANGEMENT OF HEAVY AND LIGHT SEQUENCES IN M-GENOME, JOURNAL OF VIROLOGY 19: 154 (1976). (10.1128/jvi.19.1.154-161.1976) / JOURNAL OF VIROLOGY (1976)
DAVIS, M.G., MAPPING AND EXPRESSION OF A HUMAN CYTOMEGALOVIRUS MAJOR VIRAL PROTEIN, JOURNAL OF VIROLOGY 52: 129 (1984). (10.1128/jvi.52.1.129-135.1984) / JOURNAL OF VIROLOGY (1984)
DESROSIERS, R.C., CONSTRUCTION OF REPLICATION-COMPETENT HERPESVIRUS-SAIMIRI DELETION MUTANTS, JOURNAL OF VIROLOGY 49: 343 (1984). (10.1128/jvi.49.2.343-348.1984) / JOURNAL OF VIROLOGY (1984)
GELB, L.D., VIRPLOGY: 591 (1985). / VIRPLOGY (1985)
KIEFF, E, EPSTEINBARR VIRUS AS: 392 (1985). / EPSTEINBARR VIRUS AS (1985)
Maniatis, T., Molecular Cloning: A Laboratory Manual: 118 (1982). / Molecular Cloning: A Laboratory Manual (1982)
MILLER, G, EPSTEIN-BARR VIRUS - TRANSFORMATION, CYTOPATHIC CHANGES, AND VIRAL ANTIGENS IN SQUIRREL-MONKEY AND MARMOSET LEUKOCYTES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 383 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
MILLER, G, VIROLOGY: 497 (1985). / VIROLOGY (1985)
ROBINSON R COMMUNICATION.
10.1126/science.2876520
10.1016/S0022-2836(75)80083-0

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:36 a.m.)
Indexed	4 months, 4 weeks ago (April 7, 2025, 1:26 p.m.)
Issued	38 years, 10 months ago (Oct. 31, 1986)
Published	38 years, 10 months ago (Oct. 31, 1986)
Published Print	38 years, 10 months ago (Oct. 31, 1986)

Funders 0

None

BibTeX

@article{Josephs_1986, title={Genomic Analysis of the Human B-Lymphotropic Virus (HBLV)}, volume={234}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.3020691}, DOI={10.1126/science.3020691}, number={4776}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Josephs, Steven F. and Salahuddin, S. Zaki and Ablashi, Dharam V. and Schachter, Francois and Wong-Staal, Flossie and Gallo, Robert C.}, year={1986}, month=oct, pages={601–603} }

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