DOI: 10.1126/science.2999984. Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

10.1126/science.2999984

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The products of the adenovirus-2 (Ad2) immortalizing oncogene E1A repress the activity of the SV40, polyoma virus and E1A enhancers. Evidence is presented that Ad2 infection of MPC11 plasmocytoma cells results in an inhibition of transcription of both the γ2b heavy chain (IgH) and the kappa light chain immunoglobulin genes. This inhibition is caused by the Ad2 E1A products. Furthermore, the Ad2 E1A products repress transcription activated by the immunoglobulin heavy chain enhancer in chimeric recombinants, which are either stably integrated in the genome of lymphoid cells or are present as episomes. The implications of negative regulation of cellular enhancers are discussed.

Bibliography

Hen, R., Borrelli, E., & Chambon, P. (1985). Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products. Science, 230(4732), 1391â1394.

Authors 3

René Hen (first)
Emiliana Borrelli (additional)
P. Chambon (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:28 a.m.)
Indexed	1 month, 4 weeks ago (June 26, 2025, 2:42 p.m.)
Issued	39 years, 8 months ago (Dec. 20, 1985)
Published	39 years, 8 months ago (Dec. 20, 1985)
Published Print	39 years, 8 months ago (Dec. 20, 1985)

Funders 0

None

BibTeX

@article{Hen_1985, title={Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products}, volume={230}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2999984}, DOI={10.1126/science.2999984}, number={4732}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hen, René and Borrelli, Emiliana and Chambon, P.}, year={1985}, month=dec, pages={1391–1394} }

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