DOI: 10.1126/science.2994220. Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes

Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes

10.1126/science.2994220

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The retrovirus frequently isolated from patients with the acquired immune deficiency syndrome (AIDS) has two novel open reading frames previously designated "A" and "B." The "A" region was found to be specifically expressed as polyadenylated RNA's of 5.5 and 5.0 kilobases in infected cells. The "B" region was expressed as 1.8- to 2.0-kilobase RNA species. Additional full-length and spliced messenger RNA's of the env region were also identified.

Bibliography

Rabson, A. B., Daugherty, D. F., Venkatesan, S., Boulukos, K. E., Benn, S. I., Folks, T. M., Feorino, P., & Martin, M. A. (1985). Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes. Science, 229(4720), 1388â1390.

Authors 8

Arnold B. Rabson (first)
Daryl F. Daugherty (additional)
Sundararajan Venkatesan (additional)
Kim E. Boulukos (additional)
Steven I. Benn (additional)
Thomas M. Folks (additional)
Paul Feorino (additional)
Malcolm A. Martin (additional)

References 21 Referenced 53

10.1126/science.2990040
AVIV, H, PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 1408 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
10.1126/science.6189183
BENN S unpublished data.
10.1021/bi00591a005
10.1016/0003-2697(83)90418-9
FOLKS, T, CHARACTERIZATION OF A CONTINUOUS T-CELL LINE SUSCEPTIBLE TO THE CYTOPATHIC EFFECTS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)-ASSOCIATED RETROVIRUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4539 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
KHAN A.S. unpublished data.
LEHRACH, H, RNA MOLECULAR-WEIGHT DETERMINATIONS BY GEL-ELECTROPHORESIS UNDER DENATURING CONDITIONS, A CRITICAL RE-EXAMINATION, BIOCHEMISTRY 16: 4743 (1977). (10.1021/bi00640a033) / BIOCHEMISTRY (1977)
10.1126/science.6206563
MUESING, M.A., NUCLEIC-ACID STRUCTURE AND EXPRESSION OF THE HUMAN AIDS LYMPHADENOPATHY RETROVIRUS, NATURE 313: 450 (1985). (10.1038/313450a0) / NATURE (1985)
10.1126/science.6200935
RABSON, A.B., MOLECULAR-ORGANIZATION OF THE AIDS RETROVIRUS, CELL 40: 477 (1985). (10.1016/0092-8674(85)90189-8) / CELL (1985)
RABSON, A.B., MESSENGER-RNA TRANSCRIPTS RELATED TO FULL-LENGTH ENDOGENOUS RETROVIRAL DNA IN HUMAN-CELLS, NATURE 306: 604 (1983). (10.1038/306604a0) / NATURE (1983)
10.1038/313277a0
10.1126/science.2578227
SCHWEIZER, J, SYNTHESIS INVITRO OF KERATIN POLYPEPTIDES DIRECTED BY MESSENGER-RNA ISOLATED FROM NEWBORN AND ADULT-MOUSE EPIDERMIS, EUROPEAN JOURNAL OF BIOCHEMISTRY 112: 243 (1980). (10.1111/j.1432-1033.1980.tb07200.x) / EUROPEAN JOURNAL OF BIOCHEMISTRY (1980)
10.1126/science.2990041
Thomas, P. S., Proceedings of the National Academy of Sciences of the United States of America 77: 5201 (1980). / Proceedings of the National Academy of Sciences of the United States of America (1980)
VENKATESAN S unpublished data.
10.1016/0092-8674(85)90303-4

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:36 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:27 p.m.)
Issued	39 years, 11 months ago (Sept. 27, 1985)
Published	39 years, 11 months ago (Sept. 27, 1985)
Published Print	39 years, 11 months ago (Sept. 27, 1985)

Funders 0

None

BibTeX

@article{Rabson_1985, title={Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes}, volume={229}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2994220}, DOI={10.1126/science.2994220}, number={4720}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rabson, Arnold B. and Daugherty, Daryl F. and Venkatesan, Sundararajan and Boulukos, Kim E. and Benn, Steven I. and Folks, Thomas M. and Feorino, Paul and Martin, Malcolm A.}, year={1985}, month=sep, pages={1388–1390} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        6,
        17
      ]
    ],
    "date-time": "2024-06-17T20:27:49Z",
    "timestamp": 1718656069346
  },
  "reference-count": 21,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4720",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1985,
        9,
        27
      ]
    ]
  },
  "abstract": "<jats:p>\n            The retrovirus frequently isolated from patients with the acquired immune deficiency syndrome (AIDS) has two novel open reading frames previously designated \"A\" and \"B.\" The \"A\" region was found to be specifically expressed as polyadenylated RNA's of 5.5 and 5.0 kilobases in infected cells. The \"B\" region was expressed as 1.8- to 2.0-kilobase RNA species. Additional full-length and spliced messenger RNA's of the\n            <jats:italic>env</jats:italic>\n            region were also identified.\n          </jats:p>",
  "DOI": "10.1126/science.2994220",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T19:42:50Z",
    "timestamp": 1160077370000
  },
  "page": "1388-1390",
  "source": "Crossref",
  "is-referenced-by-count": 53,
  "title": "Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes",
  "prefix": "10.1126",
  "volume": "229",
  "author": [
    {
      "given": "Arnold B.",
      "family": "Rabson",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Daryl F.",
      "family": "Daugherty",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Sundararajan",
      "family": "Venkatesan",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Kim E.",
      "family": "Boulukos",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Steven I.",
      "family": "Benn",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Thomas M.",
      "family": "Folks",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Paul",
      "family": "Feorino",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Centers for Disease Control Atlanta, Georgia 30333"
        }
      ]
    },
    {
      "given": "Malcolm A.",
      "family": "Martin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892"
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2990040"
    },
    {
      "key": "e_1_2_1_2_1",
      "first-page": "1408",
      "volume": "69",
      "year": "1972",
      "unstructured": "AVIV, H, PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 1408 (1972).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.6189183"
    },
    {
      "key": "e_1_2_1_4_1",
      "unstructured": "BENN S unpublished data."
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00591a005"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-2697(83)90418-9"
    },
    {
      "key": "e_1_2_1_7_1",
      "first-page": "4539",
      "volume": "82",
      "year": "1985",
      "unstructured": "FOLKS, T, CHARACTERIZATION OF A CONTINUOUS T-CELL LINE SUSCEPTIBLE TO THE CYTOPATHIC EFFECTS OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)-ASSOCIATED RETROVIRUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4539 (1985).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_8_1",
      "unstructured": "KHAN A.S. unpublished data."
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "4743",
      "DOI": "10.1021/bi00640a033",
      "volume": "16",
      "year": "1977",
      "unstructured": "LEHRACH, H, RNA MOLECULAR-WEIGHT DETERMINATIONS BY GEL-ELECTROPHORESIS UNDER DENATURING CONDITIONS, A CRITICAL RE-EXAMINATION, BIOCHEMISTRY 16: 4743 (1977).",
      "journal-title": "BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.6206563"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "450",
      "DOI": "10.1038/313450a0",
      "volume": "313",
      "year": "1985",
      "unstructured": "MUESING, M.A., NUCLEIC-ACID STRUCTURE AND EXPRESSION OF THE HUMAN AIDS LYMPHADENOPATHY RETROVIRUS, NATURE 313: 450 (1985).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.6200935"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "477",
      "DOI": "10.1016/0092-8674(85)90189-8",
      "volume": "40",
      "year": "1985",
      "unstructured": "RABSON, A.B., MOLECULAR-ORGANIZATION OF THE AIDS RETROVIRUS, CELL 40: 477 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "604",
      "DOI": "10.1038/306604a0",
      "volume": "306",
      "year": "1983",
      "unstructured": "RABSON, A.B., MESSENGER-RNA TRANSCRIPTS RELATED TO FULL-LENGTH ENDOGENOUS RETROVIRAL DNA IN HUMAN-CELLS, NATURE 306: 604 (1983).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/313277a0"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2578227"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1111/j.1432-1033.1980.tb07200.x",
      "volume": "112",
      "year": "1980",
      "unstructured": "SCHWEIZER, J, SYNTHESIS INVITRO OF KERATIN POLYPEPTIDES DIRECTED BY MESSENGER-RNA ISOLATED FROM NEWBORN AND ADULT-MOUSE EPIDERMIS, EUROPEAN JOURNAL OF BIOCHEMISTRY 112: 243 (1980).",
      "journal-title": "EUROPEAN JOURNAL OF BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2990041"
    },
    {
      "key": "e_1_2_1_19_1",
      "first-page": "5201",
      "volume": "77",
      "year": "1980",
      "unstructured": "Thomas, P. S., Proceedings of the National Academy of Sciences of the United States of America 77: 5201 (1980).",
      "journal-title": "Proceedings of the National Academy of Sciences of the United States of America"
    },
    {
      "key": "e_1_2_1_20_1",
      "unstructured": "VENKATESAN S unpublished data."
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(85)90303-4"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.2994220",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T15:36:06Z",
    "timestamp": 1705160166000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.2994220"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1985,
        9,
        27
      ]
    ]
  },
  "references-count": 21,
  "journal-issue": {
    "issue": "4720",
    "published-print": {
      "date-parts": [
        [
          1985,
          9,
          27
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.2994220"
  ],
  "URL": "http://dx.doi.org/10.1126/science.2994220",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1985,
        9,
        27
      ]
    ]
  }
}