The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
10.1126/science.2988123
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains, we have determined the exon organization of the gene for the low-density lipoprotein (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families.

Bibliography

Südhof, T. C., Goldstein, J. L., Brown, M. S., & Russell, D. W. (1985). The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins. Science, 228(4701), 815–822.

Authors 4
  1. Thomas C. Südhof (first)
  2. Joseph L. Goldstein (additional)
  3. Michael S. Brown (additional)
  4. David W. Russell (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited 1 year, 7 months ago (Jan. 13, 2024, 9:59 a.m.)
Indexed 9 minutes ago (Aug. 25, 2025, 11:34 p.m.)
Issued 40 years, 3 months ago (May 17, 1985)
Published 40 years, 3 months ago (May 17, 1985)
Published Print 40 years, 3 months ago (May 17, 1985)
Funders 0

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@article{S_dhof_1985, title={The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins}, volume={228}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2988123}, DOI={10.1126/science.2988123}, number={4701}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Südhof, Thomas C. and Goldstein, Joseph L. and Brown, Michael S. and Russell, David W.}, year={1985}, month=may, pages={815–822} }