DOI: 10.1126/science.2986290. Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

10.1126/science.2986290

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3′ end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.

Bibliography

Allan, J. S., Coligan, J. E., Barin, F., McLane, M. F., Sodroski, J. G., Rosen, C. A., Haseltine, W. A., Lee, T. H., & Essex, M. (1985). Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III. Science, 228(4703), 1091â1094.

Authors 9

J. S. Allan (first)
J. E. Coligan (additional)
F. Barin (additional)
M. F. McLane (additional)
J. G. Sodroski (additional)
C. A. Rosen (additional)
W. A. Haseltine (additional)
T. H. Lee (additional)
M. Essex (additional)

References 35 Referenced 449

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 9:58 a.m.)
Indexed	3 weeks ago (Aug. 2, 2025, 1:04 a.m.)
Issued	40 years, 2 months ago (May 31, 1985)
Published	40 years, 2 months ago (May 31, 1985)
Published Print	40 years, 2 months ago (May 31, 1985)

Funders 0

None

BibTeX

@article{Allan_1985, title={Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III}, volume={228}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2986290}, DOI={10.1126/science.2986290}, number={4703}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Allan, J. S. and Coligan, J. E. and Barin, F. and McLane, M. F. and Sodroski, J. G. and Rosen, C. A. and Haseltine, W. A. and Lee, T. H. and Essex, M.}, year={1985}, month=may, pages={1091–1094} }

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