DOI: 10.1126/science.2981429. HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy

HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy

10.1126/science.2981429

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.

Bibliography

Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., OâHara, C. J., Groopman, J. E., Cho, E.-S., Oleske, J. M., Wong-Staal, F., & Gallo, R. C. (1985). HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy. Science, 227(4683), 177â182.

Authors 14

George M. Shaw (first)
Mary E. Harper (additional)
Beatrice H. Hahn (additional)
Leon G. Epstein (additional)
D. Carleton Gajdusek (additional)
Richard W. Price (additional)
Bradford A. Navia (additional)
Carol K. Petito (additional)
Carl J. O'Hara (additional)
Jerome E. Groopman (additional)
Eun-Sook Cho (additional)
James M. Oleske (additional)
Flossie Wong-Staal (additional)
Robert C. Gallo (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:48 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 1:03 a.m.)
Issued	40 years, 7 months ago (Jan. 11, 1985)
Published	40 years, 7 months ago (Jan. 11, 1985)
Published Print	40 years, 7 months ago (Jan. 11, 1985)

Funders 0

None

BibTeX

@article{Shaw_1985, title={HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy}, volume={227}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2981429}, DOI={10.1126/science.2981429}, number={4683}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Shaw, George M. and Harper, Mary E. and Hahn, Beatrice H. and Epstein, Leon G. and Gajdusek, D. Carleton and Price, Richard W. and Navia, Bradford A. and Petito, Carol K. and O’Hara, Carl J. and Groopman, Jerome E. and Cho, Eun-Sook and Oleske, James M. and Wong-Staal, Flossie and Gallo, Robert C.}, year={1985}, month=jan, pages={177–182} }

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