DOI: 10.1126/science.2972065. Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

10.1126/science.2972065

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Monocytes and macrophages, which may play a central role in the pathogenesis of infection with human immunodeficiency virus type 1 (HIV-1), express the CD4 molecule and Fc receptors (FcR) for immunoglobulin G (IgG). To explore the possibility that FcR mediate HIV-1 infection of monocytes, studies were conducted with the human monocytic cell line U937. These cells were exposed to HIV-1 complexed with various concentrations of serum from HIV-1 antibody-positive individuals and monitored for HIV-1 replication. Serum samples from antibody-negative normal individuals did not affect virus yields. High concentrations of antibody-positive sera showed virus-neutralizing activity; however, cells infected with HIV-1 in the presence of antibody-positive sera at subneutralizing concentrations significantly enhanced virus replication. This infection enhancement was blocked by heat-aggregated γ-globulin. Moreover, the IgG fraction from an HIV-1 antibody-positive serum enhanced HIV-1 infection at the same serum dilution equivalents. In contrast, IgG-F(abγ) 2 did not enhance HIV-1 infection but showed neutralizing activity with HIV-1. These results are compatible with the concept of FcR-mediated infection enhancement and suggest that this immunological response to HIV-1, instead of protecting the host, potentially facilitates the infection.

Bibliography

Takeda, A., Tuazon, C. U., & Ennis, F. A. (1988). Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry. Science, 242(4878), 580â583.

Authors 3

Akira Takeda (first)
Carmelita U. Tuazon (additional)
Francis A. Ennis (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 10:14 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 2, 2025, 12:42 a.m.)
Issued	36 years, 10 months ago (Oct. 28, 1988)
Published	36 years, 10 months ago (Oct. 28, 1988)
Published Print	36 years, 10 months ago (Oct. 28, 1988)

Funders 0

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BibTeX

@article{Takeda_1988, title={Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry}, volume={242}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2972065}, DOI={10.1126/science.2972065}, number={4878}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Takeda, Akira and Tuazon, Carmelita U. and Ennis, Francis A.}, year={1988}, month=oct, pages={580–583} }

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