DOI: 10.1126/science.2969618. cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

10.1126/science.2969618

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Interleukin-1 alpha and -1 beta (IL-1α and IL-1β) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1α and IL-1β in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.

Bibliography

Sims, J. E., March, C. J., Cosman, D., Widmer, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignall, J. M., Jackson, J. L., Call, S. M., Friend, D., Alpert, A. R., Gillis, S., Urdal, D. L., & Dower, S. K. (1988). cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily. Science, 241(4865), 585â589.

Authors 15

John E. Sims (first)
Caril J. March (additional)
David Cosman (additional)
Michael B. Widmer (additional)
H. Robson MacDonald (additional)
Catherine J. McMahan (additional)
Catherine E. Grubin (additional)
Janis M. Wignall (additional)
Jana L. Jackson (additional)
Susan M. Call (additional)
Della Friend (additional)
Alan R. Alpert (additional)
Steven Gillis (additional)
David L. Urdal (additional)
Steven K. Dower (additional)

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10.1038/323226a0

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 9:54 a.m.)
Indexed	1 day, 10 hours ago (Aug. 28, 2025, 8:54 a.m.)
Issued	37 years, 1 month ago (July 29, 1988)
Published	37 years, 1 month ago (July 29, 1988)
Published Print	37 years, 1 month ago (July 29, 1988)

Funders 0

None

BibTeX

@article{Sims_1988, title={cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily}, volume={241}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2969618}, DOI={10.1126/science.2969618}, number={4865}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sims, John E. and March, Caril J. and Cosman, David and Widmer, Michael B. and MacDonald, H. Robson and McMahan, Catherine J. and Grubin, Catherine E. and Wignall, Janis M. and Jackson, Jana L. and Call, Susan M. and Friend, Della and Alpert, Alan R. and Gillis, Steven and Urdal, David L. and Dower, Steven K.}, year={1988}, month=jul, pages={585–589} }

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